Results 11 to 20 of about 981 (132)

Hearing loss in outbred Hartley guinea pigs experimentally infected with Pichinde virus as a surrogate model of human mammarenaviral hemorrhagic fevers [PDF]

Virulence, 2022
Lassa fever (LF) is a neglected tropical disease that is caused by Lassa virus (LASV), a human hemorrhagic fever-causing mammarenavirus. A notable sequela of LF is sensorineural hearing loss (SNHL) that can develop in about 33% of the patients.
Morgan Brisse, Claudia Fernández-Alarcón, Qinfeng Huang, Natalie Kirk, Mark R. Schleiss, Yuying Liang, Hinh Ly   +6 more
doaj   +2 more sources

Pichinde virus induces microvascular endothelial cell permeability through the production of nitric oxide [PDF]

Virology Journal, 2009
This report is the first to demonstrate infection of human endothelial cells by Pichinde virus (PIC). PIC infection induces an upregulation of the inducible nitric oxide synthase gene; as well as an increase in detectable nitric oxide (NO).
Voss Thomas G, Brocato Rebecca L
doaj   +2 more sources

Evaluating Antigen- and Vector-Specific Immune Responses of a Recombinant Pichinde Virus-Based Vaccine Expressing the Lymphocytic Choriomeningitis Virus Nucleoprotein [PDF]

Vaccines
Background: Live viral vector-based vaccines are known to elicit strong immune responses, but their use can be limited by anti-vector immunity. Here, we analyzed the immunological responses of a live-attenuated recombinant Pichinde virus (PICV) vector ...
Michaela Cain, Qinfeng Huang, Shania Sanchez, Hinh Ly, Yuying Liang   +4 more
doaj   +2 more sources

Proteomic analysis of Pichindé virus infection identifies differential expression of prothymosin-alpha. [PDF]

J Biomed Biotechnol, 2010
The arenaviruses include a number of important pathogens including Lassa virus and Junin virus. Presently, the only treatment is supportive care and the antiviral Ribavirin. In the event of an epidemic, patient triage may be required to more effectively manage resources; the development of prognostic biomarker signatures, correlating with disease ...
Bowick GC, Soman KV, Wang H, Aronson JF, Luxon BA, Lomas LO, Gorenstein DG, Herzog NK.   +7 more
europepmc   +2 more sources

Immunogenicity and Protective Efficacy of a Recombinant Pichinde Viral-Vectored Vaccine Expressing Influenza Virus Hemagglutinin Antigen in Pigs

Vaccines, 2022
Influenza A virus of swine (IAV-S) is an economically important swine pathogen. The IAV-S hemagglutinin (HA) surface protein is the main target for vaccine development.
Sushmita Kumari, Jayeshbhai Chaudhari, Qinfeng Huang, Phillip Gauger, Marcelo Nunes De Almeida, Yuying Liang, Hinh Ly, Hiep L. X. Vu   +7 more
doaj   +3 more sources

AP-1-Targeting Decoy Oligonucleotides: Mechanisms and Therapeutic Potential as Modulators of Inflammatory Pathways. [PDF]

J Cell Mol Med
ABSTRACT Numerous cellular functions, such as apoptosis, proliferation, differentiation, survival, transformation and cell migration, are regulated by a crucial transcription factor called activator protein 1 (AP‐1). Growing evidence indicates that AP‐1 is involved in severe conditions like fibrosis, cancer, and organ damage, as well as inflammatory ...
Mahjoubin-Tehran M, Rezaei S, Sukhorukov VN, Jalili A, Kesharwani P, Sahebkar A.   +5 more
europepmc   +2 more sources

Enhancing the use of T cells as a universal preventive measure against H3N2 influenza: Mechanism and implications. [PDF]

Health Sci Rep
Health Science Reports, Volume 7, Issue 8, August 2024.
Bhatt JH, Kagathara N, Mehta K, Joshi M, Omar MA.   +4 more
europepmc   +2 more sources

Characterization of the Glycoprotein Stable Signal Peptide in Mediating Pichinde Virus Replication and Virulence. [PDF]

J Virol, 2016
ABSTRACT Arenaviruses can cause lethal hemorrhagic fevers in humans with few preventative and therapeutic measures. The arenaviral glycoprotein stable signal peptide (SSP) is unique among signal peptides in that it is an integral component of the mature glycoprotein complex (GPC) and plays important roles not only in GPC ...
Shao J, Liu X, Ly H, Liang Y.
europepmc   +4 more sources

Preclinical evaluation of two phylogenetically distant arenavirus vectors for the development of novel immunotherapeutic combination strategies for cancer treatment [PDF]

Journal for ImmunoTherapy of Cancer
Background Engineered arenavirus vectors have recently been developed to leverage the body’s immune system in the fight against chronic viral infections and cancer. Vectors based on Pichinde virus (artPICV) and lymphocytic choriomeningitis virus (artLCMV)
Pedro Berraondo, Catarina Pinto, Sarah Schmidt, Henning Lauterbach, Timo Schippers, Josipa Raguz, Theresa Pölzlbauer, Mohamed Habbeddine, Sandra Rosskopf, Judith Strauß, Valentin Just, Katell Bidet Huang, Felix Stemeseder, Ethan Stewart, Jakub Jez, Klaus K. Orlinger   +15 more
doaj   +2 more sources

Interferon alfacon-1 protects hamsters from lethal pichinde virus infection. [PDF]

Antimicrob Agents Chemother, 2005
ABSTRACT Hemorrhagic fever of arenaviral origin is a frequently fatal infectious disease of considerable priority to the biodefense mission. Historically, the treatment of arenaviral infections with alpha interferons has not yielded favorable results.
Gowen BB, Barnard DL, Smee DF, Wong MH, Pace AM, Jung KH, Winslow SG, Bailey KW, Blatt LM, Sidwell RW.   +9 more
europepmc   +5 more sources