Characterization of virulence-associated determinants in the envelope glycoprotein of Pichinde virus [PDF]
Virology, 2012 We use a small animal model, based on guinea pigs infected with a non-pathogenic Pichinde virus (PICV), to understand the virulence mechanisms of arenavirus infections in the hosts. PICV P2 strain causes a mild febrile reaction in guinea pigs, while P18 causes severe disease with clinical and pathological features reminiscent of Lassa hemorrhagic fever
Shuiyun Lan, Hinh Ly, Yuying Liang
exaly +4 more sources
Recombinant Tri-Segmented Pichinde Virus as a Novel Live Viral Vaccine Platform [PDF]
Methods in Molecular Biology, 2017 Pichinde virus (PICV) is a nonpathogenic arenavirus with a bi-segmented RNA genome (L and S segments) that encodes four viral genes. We have developed a reverse genetics system to generate recombinant tri-segmented PICV (rP18tri) that packages three RNA segments (L, S1, and S2) and can encode up to two foreign genes.
Hinh Ly, Yuying Liang, Ly Hinh
exaly +5 more sources
Preclinical evaluation of two phylogenetically distant arenavirus vectors for the development of novel immunotherapeutic combination strategies for cancer treatment [PDF]
Journal for ImmunoTherapy of CancerBackground Engineered arenavirus vectors have recently been developed to leverage the body’s immune system in the fight against chronic viral infections and cancer. Vectors based on Pichinde virus (artPICV) and lymphocytic choriomeningitis virus (artLCMV)
Pedro Berraondo +15 more
doaj +2 more sources
Evaluating the Biological Role of Lassa Viral Z Protein-Mediated RIG-I Inhibition Using a Replication-Competent Trisegmented Pichinde Virus System in an Inducible RIG-IN Expression Cell Line [PDF]
Journal of Virology, 2022 Da Di, Hinh Ly, Yuying Liang
exaly +2 more sources
Proteomic analysis of Pichindé virus infection identifies differential expression of prothymosin-alpha. [PDF]
J Biomed Biotechnol, 2010 The arenaviruses include a number of important pathogens including Lassa virus and Junin virus. Presently, the only treatment is supportive care and the antiviral Ribavirin. In the event of an epidemic, patient triage may be required to more effectively manage resources; the development of prognostic biomarker signatures, correlating with disease ...
Bowick GC +7 more
europepmc +2 more sources
Enhancing the use of T cells as a universal preventive measure against H3N2 influenza: Mechanism and implications. [PDF]
Health Sci RepHealth Science Reports, Volume 7, Issue 8, August 2024.
Bhatt JH +4 more
europepmc +2 more sources
Vaccines, 2022 Influenza A virus of swine (IAV-S) is an economically important swine pathogen. The IAV-S hemagglutinin (HA) surface protein is the main target for vaccine development.
Sushmita Kumari +7 more
doaj +1 more source
Polymerase Activity of Pichinde Virus [PDF]
Journal of Virology, 1974 Pichinde virus, a member of the arenavirus group, was examined for polymerase activity. Purified virus was found to contain RNA-dependent RNA polymerase but not RNA-dependent DNA polymerase activity. Since RNase but neither DNase nor actinomycin D inhibited the endogenous polymerase reaction, RNA of the virus appeared to be used as the ...
M F, Carter, N, Biswal, W E, Rawls
openaire +2 more sources
Loss of anti-viral immunity by infection with a virus encoding a cross-reactive pathogenic epitope. [PDF]
PLoS Pathogens, 2012 T cell cross-reactivity between different strains of the same virus, between different members of the same virus group, and even between unrelated viruses is a common occurrence.
Alex T Chen +9 more
doaj +1 more source
Observation of arenavirus nucleoprotein heptamer assembly
FEBS Open Bio, Volume 11, Issue 4, Page 1076-1083, April 2021., 2021 The nucleoprotein associates with RNA to form a ribonucleoprotein complex. The nucleoprotein trends to self‐assemble into heptameric rings. Theses rings represent stable intermediate states representative of the average full turn of the Arenaviridae ribonucleoprotein filament.
Nicolas Papageorgiou +6 more
wiley +1 more source