Results 111 to 120 of about 979 (130)
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Biophysical and Biochemical Studies of Pichinde Virus
1973Pichinde virus, a member of the arenavirus group, was found to contain single-stranded RNA. The RNA consisted of 5 discernible components corresponding to 31S, 28S, 22S, 18S and 4 to 6S. The 28S and 18S RNA’s appeared to be of host cell origin and the 4 to 6S RNA was probably from the same source.
W. E. Rawls +2 more
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Pichinde virus L and S RNAs contain unique sequences
Journal of Virology, 1981Using oligodeoxyribonucleotides produced by limited DNase I digestion of calf thymus DNA as a primer, we synthesized complementary DNA (cDNA) from the L and the S RNAs of Pichinde virus. The reaction conditions for in vitro cDNA synthesis were optimized to allow transcription of about 90% of either L or S RNA.
W C, Leung +5 more
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Immune recognition of tumor cells in mice infected with Pichinde virus
Cancer Immunology Immunotherapy, 1984Pichinde virus (PV), a member of the Arenaviridae family, protects mice from a lethal inoculation with the sarcoma 180 (S180) tumor cell line. Virus replication, which is required for protection, occurs primarily in the spleen and tumor. During the first 4 days, elevated natural killer (NK) cell activity parallels an increase in serum interferon in PV ...
N, Molomut +4 more
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Evaluation of plaque size reduction as a method for the detection of pichinde virus antibody
Archives of Virology, 1980The reaction between Pichinde virus and homologous antisera has been studied using a plaque size reduction method. The incorporation of antiserum in the overlay of infected Vero cell monolayers revealed a pattern of virus-cell interactions which were manifested by both a significant reduction in the diameter of virus plaques, and regeneration of cells ...
Chanas, AC +5 more
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Cloning and expression of the glycoproteins of pichinde virus by vaccinia virus.
2009Pichinde virus (Pic), like the other arenaviruses, possesses two glycoproteins, GP1 and GP2, that are derived by proteolytic cleavage from a precursor molecule, GPC. Within the arenaviruses, GP1 is the most heterogeneous protein, and GP1 of Pic differs from that of the other arenaviruses in having twice as many potential N-linked glycosylation sites ...
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Characterization of polypeptides immunoprecipitable from Pichinde virus-infected BHK-21 cells
Journal of Virology, 1981Using hamster anti-Pichinde virus serum, we immunoprecipitated polypeptides from BHK-21 cells infected with Pichinde virus. Seven immunoprecipitable polypeptides exhibited a time- and multiplicity of infection-dependent appearance when the cultures were pulse-labeled with L-[35S]methionine for 1 h.
D G, Harnish, W C, Leung, W E, Rawls
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Observation of the in situ contracting heart of guinea pigs infected with Pichinde virus
Life Sciences, 1987The in situ beating hearts from anesthetized control and Pichinde virus-infected strain 13 guinea pigs, between days 7 and 19 postinoculation, were directly observed and video recorded. Although some hearts from Pichinde virus-infected animals were visually depressed and had altered contraction patterns, such a pronounced cardiac dysfunction was not ...
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Mapping the cytotoxic T-lymphocyte epitopes of Pichinde virus.
2009One of the aims of this study was to determine whether the glycoproteins of Pichinde virus harbour any cytotoxic T-lymphocyte (CTL) epitopes on the murine haplotypes, H-2$\sp{\rm b}$ and H-2$\sp{\rm d}$ since, on neither of these MHC backgrounds are there any CTL epitopes on the nucleoprotein of this virus.
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Laboratory investigation; a journal of technical methods and pathology, 1977
The course of Pichinde virus infection in two strains of hamsters, LVG and MHA, was studied by sequential frozen-section immunofluorescence and light and electron microscopy. The major destructive effects of the infection were in the spleen and liver.
F A, Murphy, M J, Buchmeier, W E, Rawls
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The course of Pichinde virus infection in two strains of hamsters, LVG and MHA, was studied by sequential frozen-section immunofluorescence and light and electron microscopy. The major destructive effects of the infection were in the spleen and liver.
F A, Murphy, M J, Buchmeier, W E, Rawls
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Characterization of temperature sensitive mutants of Pichinde virus
Virus Research, 1985Malathi Prakash +3 more
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