Results 51 to 60 of about 10,616 (171)

Association Between the Dutch Mediterranean‐Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND‐NL) Diet Adherence and Systemic Tryptophan Metabolites in Older Adults at Risk of Cognitive Decline: An Exploratory Study

Molecular Nutrition &Food Research, Volume 70, Issue 1, January 2026.
Following the MIND diet may support brain health in older adults at risk of cognitive decline by influencing tryptophan (TRP) metabolism. Plasma samples and dietary intake data from the HELI intervention trial were used. Bivariate latent change score modeling analysis showed that greater adherence to the MIND diet was linked to higher tryptophan levels,
Sonja Beers, Lisette C. P. G. M. de Groot, Mark R. van Loenen, Lianne B. Remie, Mechteld Grootte Bromhaar, Andrea Anesi, Urska Vrhovsek, Joukje M. Oosterman, Esther Aarts, Mara P. H. van Trijp, Yannick Vermeiren   +10 more
wiley   +1 more source

Support Vector Machine Identification of Small Molecule Binders to an Understudied Allosteric Site of SARS‐CoV‐2 Mpro for Next‐Generation PROTAC‐Based Therapeutics

Archiv der Pharmazie, Volume 358, Issue 12, December 2025.
An SVM‐based ML model identified 180 potential SARS‐CoV‐2 Mpro inhibitors. MST experiments confirmed three high‐affinity binders, with one showing Kd = 2.8 ± 0.9 μM. These compounds are non‐competitive, suggesting binding to a novel allosteric site.
Enrico Mario Alessandro Fassi, Nedra Mekni, Marco Albani, Sabine Maehrlein, Annabelle Carolin Weldert, Tanja Schirmeister, Thierry Langer, Giovannf razioso   +7 more
wiley   +1 more source

Diaquabis(picolinato N-oxide-κ2O,O′)zinc(II)

Acta Crystallographica Section E, 2008
In the title compound, [Zn(C6H4NO3)2(H2O)2], the Zn atom is located on a centre of inversion and shows a distorted octahedral coordination geometry. Two aqua ligands occupy the axial positions and four O atoms of the two chelating picolinic acid N-oxide ...
Xiu-Bing Li, Run-Ling Shang, Bai-Wang Sun   +2 more
doaj   +1 more source

Electrochemical Synthesis of Nicotinic Acid from ��-Picoline

, 1988
Department of Chemistry, Kashmir University, Srinagar-190 006 Manuscript received 18 February 1988, revised 19 May 1988, accepted 8 June 1988 Electrosyathesis or nicotinic acid from -picoline by potentiostatic oxidation is reported. Efficencies of different electrodes are compared by considering changes in concentration of anolyte and substrate ...
P. N. GUPTA, G. M. RATHER
openaire   +1 more source

Plectranthus‐derived Abietanes as Protein Kinase C‐δ Activators: In Silico Design, Human Serum Albumin Interaction, and Stability Evaluation

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Cancer remains a major global health challenge. Among protein kinases (PKCs), PKC‐δ acts as a tumor suppressor in colon cancer and represents a valuable therapeutic target. Human serum albumin (HSA) is gaining attention as an efficient drug carrier, while Plectranthus spp. offers a rich source of bioactive compounds.
Vera M. S. Isca, Milan Nikolić, Nenad Filipović, Mattia Mori, Patricia Rijo   +4 more
wiley   +1 more source

Green and Sustainable Chemistry Approaches on Azide‐Based Click Reactions in Polymer Science

Macromolecular Rapid Communications, Volume 46, Issue 23, December 5, 2025.
Click Chemistry, particularly the azide‐alkyne cycloaddition (AAC) reaction, has revolutionized polymer chemistry, enabling precise and efficient synthesis of advanced functional materials. With its high regioselectivity, mild reaction conditions, and versatility, AAC reactions align closely with the principles of Green and Sustainable Chemistry.
Hatice Mutlu, Bercis Pektas, C. Remzi Becer, Azra Kocaarslan   +3 more
wiley   +1 more source

Characterization of inhibitory effects of the potential therapeutic inhibitors, benzoic acid and pyridine derivatives, on the monophenolase and diphenolase activities of tyrosinase [PDF]

Iranian Journal of Basic Medical Sciences, 2015
Objective(s):Involvement of tyrosinase in the synthesis of melanin and cell signaling pathway has made it an attractive target in the search for therapeutic inhibitors for treatment of different skin hyperpigmentation disorders and melanoma cancers ...
Nematollah Gheibi, Negar Taherkhani, Abolfazl Ahmadi, Kamahldin Haghbeen, Dariush Ilghari   +4 more
doaj  

Tryptophan derivatives as non‐invasive diagnostic indicators for obesity‐related MASLD in children and adolescents

Diabetes, Obesity and Metabolism, Volume 27, Issue 12, Page 7544-7560, December 2025.
Abstract Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) represents a major health burden in children and adolescents with obesity. This study aimed to characterize metabolic alterations associated with obesity‐related MASLD and to evaluate the potential of tryptophan (TRP)‐derived metabolites as non‐invasive biomarkers for early ...
Shumin Zhan, Xingyun Wang, Chen Wang, Bowen Zhu, Jianfang Gao, Zhou Peng, Rui Wang, Yun Yang, Liang Zhang, Tengfei Wang, Jiaoxiang Wu, Wei Wu, Ke Huang, Guanping Dong, Qiannan Ren, Shan Wang, Senjie Wang, Xuelian Zhou, Liling Xu, Junfen Fu, Xirong Guo   +20 more
wiley   +1 more source

Fe‐Photocatalyzed Decarboxylative Giese‐Type Reaction of α‐N, O or S Carboxylic Acids: Insight into the Mechanism of the Radical Formation

Advanced Synthesis &Catalysis, Volume 367, Issue 21, November 13, 2025.
Electron‐deficient alkenes can be functionalized with α‐amino, α‐alkoxy and α‐alkylthio radicals formed by Fe‐photocatalyzed decarboxylation of the corresponding carboxylic acids. The reactions proceed under smooth ligandless conditions with inexpensive base and in the absence of oxidant. A mechanistic computational TD‐DFT study supports the occurrence
Fernando Pérez‐Maseda, María Martín, Jorge Labrador‐Santiago, Inés Corral, Diego J. Cárdenas   +4 more
wiley   +1 more source