Results 71 to 80 of about 5,893,231 (219)

Non-Acidic Free Fatty Acid Receptor 4 Agonists with Antidiabetic Activity [PDF]

, 2016
The free fatty acid receptor 4 (FFA4 or GPR120) has appeared as an interesting potential target for the treatment of metabolic disorders. At present, most FFA4 ligands are carboxylic acids that are assumed to mimic the endogenous long-chain fatty acid ...
Azevedo, Carlos, Christiansen, Elisabeth, Dunlop, Julia, Hansen, Steffen, Hudson, Brian, Kępczyńska, Malgorzata A., Milligan, Graeme, Shumpukade, Bharat, Stocker, Claire J., Ulven, Trond, Wargent, Edward T., Watterson, Kenneth   +11 more
core   +3 more sources

Green and Sustainable Chemistry Approaches on Azide‐Based Click Reactions in Polymer Science

Macromolecular Rapid Communications, Volume 46, Issue 23, December 5, 2025.
Click Chemistry, particularly the azide‐alkyne cycloaddition (AAC) reaction, has revolutionized polymer chemistry, enabling precise and efficient synthesis of advanced functional materials. With its high regioselectivity, mild reaction conditions, and versatility, AAC reactions align closely with the principles of Green and Sustainable Chemistry.
Hatice Mutlu, Bercis Pektas, C. Remzi Becer, Azra Kocaarslan   +3 more
wiley   +1 more source

Mechanistic investigations of the asymmetric hydrosilylation of ketimines with trichlorosilane reveals a dual activation model and an organocatalyst with enhanced efficiency. [PDF]

, 2017
Structural probes used to help elucidate mechanistic information of the organocatalyzed asymmetric ketimine hydrosilylation have revealed a new catalyst with unprecedented catalytic activity, maintaining adequate performance at 0.01 mol% loading.
A. T. Reeder, Baudequin, Bonsignore, Braun, Cowley, El-Fayyoumy, F. Torri, Gautier, Gautier, Guizzetti, Guizzetti, H. Adams, Hagemann, Imamoto, Iwasaki, Jones, Jones, Malkov, Malkov, Malkov, Nakayama, Ngochindo, Onomura, Pei, Pei, S. Jones, Shirley, Sugiura, Wang, Warner, X. Li, Xiao, Zhang, Zheng   +33 more
core   +1 more source

Effects of Heat Exposure on Kynurenine Pathway Metabolism—Comparison Between Exertional and Exogenous Heating of the Human Body

Acta Physiologica, Volume 241, Issue 12, December 2025.
ABSTRACT Background The kynurenine pathway (KP) plays a pivotal role in many diseases that involve distinct pathological mechanisms. Objectives Since KP metabolites are potential disease biomarkers, it is crucial to investigate their fluctuations under physiological conditions.
Varvara Louvrou, Nerijus Eimantas, Ema Juškevičiūtė, Rima Solianik, Marius Brazaitis, Göran Engberg, Sophie Erhardt   +6 more
wiley   +1 more source

Tryptophan derivatives as non‐invasive diagnostic indicators for obesity‐related MASLD in children and adolescents

Diabetes, Obesity and Metabolism, Volume 27, Issue 12, Page 7544-7560, December 2025.
Abstract Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) represents a major health burden in children and adolescents with obesity. This study aimed to characterize metabolic alterations associated with obesity‐related MASLD and to evaluate the potential of tryptophan (TRP)‐derived metabolites as non‐invasive biomarkers for early ...
Shumin Zhan, Xingyun Wang, Chen Wang, Bowen Zhu, Jianfang Gao, Zhou Peng, Rui Wang, Yun Yang, Liang Zhang, Tengfei Wang, Jiaoxiang Wu, Wei Wu, Ke Huang, Guanping Dong, Qiannan Ren, Shan Wang, Senjie Wang, Xuelian Zhou, Liling Xu, Junfen Fu, Xirong Guo   +20 more
wiley   +1 more source

Charge Transfer-oxy Radical Mechanism for Anti-cancer Agents [PDF]

, 1986
The proposal is advanced that anti-cancer drugs generally function by charge transfer resulting in formation of toxic oxy radicals which destroy the neoplasm.
Ames, James R., Cox, O., Elo, Hannu, Kovacic, Peter, Lumme, Paavo, Ryan, Michael D.   +5 more
core   +1 more source

Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer. [PDF]

, 2016
Renal cell carcinoma (RCC) is increasing in incidence, and a complete cure remains elusive. While immune-checkpoint antibodies are promising, interferon-based immunotherapy has been disappointing.
Abu Aboud, Omran, Anderson, Katie, Berryhill, Grace, Chen, Ching-Hsien, Graef, Ashley, Hovey, Russell C, Kim, Jeffrey, Modiano, Jaime F, Sarver, Aaron L, Stewart, Benjamin, Trott, Josephine F, Uzal, Francisco, Weiss, Robert H, Wettersten, Hiromi   +13 more
core   +2 more sources

Fe‐Photocatalyzed Decarboxylative Giese‐Type Reaction of α‐N, O or S Carboxylic Acids: Insight into the Mechanism of the Radical Formation

Advanced Synthesis &Catalysis, Volume 367, Issue 21, November 13, 2025.
Electron‐deficient alkenes can be functionalized with α‐amino, α‐alkoxy and α‐alkylthio radicals formed by Fe‐photocatalyzed decarboxylation of the corresponding carboxylic acids. The reactions proceed under smooth ligandless conditions with inexpensive base and in the absence of oxidant. A mechanistic computational TD‐DFT study supports the occurrence
Fernando Pérez‐Maseda, María Martín, Jorge Labrador‐Santiago, Inés Corral, Diego J. Cárdenas   +4 more
wiley   +1 more source

Comparison of the Plasma Metabolome Profiles Between the Internal Thoracic Artery and Ascending Aorta in Patients Undergoing Coronary Artery Bypass Graft Surgery Using Gas Chromatography Time-of-Flight Mass Spectrometry. [PDF]

, 2019
BackgroundThe left internal thoracic artery (LITA) has been used as the first conduit of choice in coronary artery bypass grafting (CABG) because of excellent long-term patency and outcomes.
Cho, Joo Youn, Hwang, Ho Young, Jang, Cholsoon, Jang, In Jin, Kim, Andrew HyoungJin, Kim, Ji Seong, Kim, Ki Bong   +6 more
core  

MALDI-TOF mass spectrometry in textile industry [PDF]

, 2008
In this paper are presented the possibilities of using matrix assisted laser desorption ionization time of flight (MALDI-TOF) mass spectrometry in textile industry.
Dinca, Nicolae, Munteanu, Florentina-Daniela, Paulo, Artur Cavaco   +2 more
core   +1 more source