Results 11 to 20 of about 10,899,927 (248)

Genomic Characterization of Lactobacillus delbrueckii TUA4408L and Evaluation of the Antiviral Activities of its Extracellular Polysaccharides in Porcine Intestinal Epithelial Cells

Frontiers in Immunology, 2018
In lactic acid bacteria, the synthesis of exopolysaccharides (EPS) has been associated with some favorable technological properties as well as health-promoting benefits.
Paulraj Kanmani, Paulraj Kanmani, Leonardo Albarracin, Leonardo Albarracin, Leonardo Albarracin, Hisakazu Kobayashi, Hisakazu Kobayashi, Elvira Maria Hebert, Lucila Saavedra, Ryoya Komatsu, Ryoya Komatsu, Brian Gatica, Ayako Miyazaki, Wakako Ikeda-Ohtsubo, Wakako Ikeda-Ohtsubo, Yoshihito Suda, Hisashi Aso, Hisashi Aso, Shintaro Egusa, Takashi Mishima, Alexis Salas-Burgos, Hideki Takahashi, Hideki Takahashi, Julio Villena, Julio Villena, Haruki Kitazawa, Haruki Kitazawa   +26 more
doaj   +2 more sources

Paraimmunobiotic Bifidobacteria Modulate the Expression Patterns of Peptidoglycan Recognition Proteins in Porcine Intestinal Epitheliocytes and Antigen Presenting Cells

Cells, 2019
Peptidoglycan recognition proteins (PGLYRPs) are a family of pattern recognition receptors (PRRs) that are able to induce innate immune responses through their binding to peptidoglycan (PGN), lipopolysaccharide, or lipoteichoic acid, or by interacting ...
Hikaru Iida, Masanori Tohno, Md. Aminul Islam, Nana Sato, Hisakazu Kobayashi, Leonardo Albarracin, AKM Humayun Kober, Wakako Ikeda-Ohtsubo, Yoshihito Suda, Hisashi Aso, Tomonori Nochi, Ayako Miyazaki, Hirohide Uenishi, Noriyuki Iwabuchi, Jin-zhong Xiao, Julio Villena, Haruki Kitazawa   +16 more
doaj   +2 more sources

Efficient circular RNA engineering by end-to-end self-targeting and splicing reaction using Tetrahymena group I intron ribozyme

Molecular Therapy: Nucleic Acids, 2023
Circular RNA (circRNA) has various advantages over linear mRNA that is gaining success as a new vaccine and therapeutic agent. Thus, circRNA and its engineering methods have attracted attention recently. In this study, we developed a new in vitro circRNA
Kyung Hyun Lee, Seongcheol Kim, Jaehwi Song, Seung Ryul Han, Ji Hyun Kim, Seong-Wook Lee   +5 more
doaj   +2 more sources

Immunobiotic Bifidobacteria Strains Modulate Rotavirus Immune Response in Porcine Intestinal Epitheliocytes via Pattern Recognition Receptor Signaling. [PDF]

PLoS ONE, 2016
In this work, we aimed to characterize the antiviral response of an originally established porcine intestinal epithelial cell line (PIE cells) by evaluating the molecular innate immune response to rotavirus (RVs).
Takamasa Ishizuka, Paulraj Kanmani, Hisakazu Kobayashi, Ayako Miyazaki, Junichi Soma, Yoshihito Suda, Hisashi Aso, Tomonori Nochi, Noriyuki Iwabuchi, Jin-zhong Xiao, Tadao Saito, Julio Villena, Haruki Kitazawa   +12 more
doaj   +2 more sources

Immunoregulatory Effects Triggered by Lactic Acid Bacteria Exopolysaccharides: New Insights into Molecular Interactions with Host Cells

Microorganisms, 2016
Researchers have demonstrated that lactic acid bacteria (LAB) with immunomodulatory capabilities (immunobiotics) exert their beneficial effects through several molecules, including cell wall, peptidoglycan, and exopolysaccharides (EPS), that are able to ...
Jonathan Laiño, Julio Villena, Paulraj Kanmani, Haruki Kitazawa   +3 more
doaj   +2 more sources

Immunobiotic lactic acid bacteria beneficially regulate immune response triggered by poly(I:C) in porcine intestinal epithelial cells

Veterinary Research, 2011
This study analyzed the functional expression of TLR3 in various gastrointestinal tissues from adult swine and shows that TLR3 is expressed preferentially in intestinal epithelial cells (IEC), CD172a+CD11R1high and CD4+ cells from ileal Peyer's patches ...
Hosoya Shoichi, Villena Julio, Shimazu Tomoyuki, Tohno Masanori, Fujie Hitomi, Chiba Eriko, Shimosato Takeshi, Aso Hisashi, Suda Yoshihito, Kawai Yasushi, Saito Tadao, Alvarez Susana, Ikegami Shuji, Itoh Hiroyuki, Kitazawa Haruki   +14 more
doaj   +2 more sources

Lipoteichoic Acid Is Involved in the Ability of the Immunobiotic Strain Lactobacillus plantarum CRL1506 to Modulate the Intestinal Antiviral Innate Immunity Triggered by TLR3 Activation

Frontiers in Immunology, 2020
Studies have demonstrated that lipoteichoic acid (LTA) is involved in the immunomodulatory properties of some immunobiotic lactobacilli. The aim of this work was to evaluate whether LTA contributes to the capacity of Lactobacillus plantarum CRL1506 in ...
Hiroya Mizuno, Lorena Arce, Kae Tomotsune, Kae Tomotsune, Leonardo Albarracin, Leonardo Albarracin, Ryutaro Funabashi, Ryutaro Funabashi, Daniela Vera, Daniela Vera, Md. Aminul Islam, Md. Aminul Islam, Maria Guadalupe Vizoso-Pinto, Maria Guadalupe Vizoso-Pinto, Hideki Takahashi, Yasuko Sasaki, Haruki Kitazawa, Haruki Kitazawa, Julio Villena, Julio Villena   +19 more
doaj   +2 more sources

Scarless circular mRNA-based CAR-T cell therapy elicits superior antitumor efficacy [PDF]

Signal Transduction and Targeted Therapy
Messenger RNA (mRNA)-based transient expression of chimeric antigen receptors (CARs) results in optimal safety profiles and provides promising opportunities to address existing challenges associated with viral vector-based CAR-T-cell therapies and to ...
Qinchao Hu, Hui Zhao, Kaicheng Zhou, Xuefei Tian, Qian Wang, Xianxin Hua, Xuyao Zhang   +6 more
doaj   +2 more sources

In vitro evaluation of the immunomodulatory and wakame assimilation properties of Lactiplantibacillus plantarum strains from swine milk

Frontiers in Microbiology
The emergence and spread of antibiotic resistance threat forced to explore alternative strategies for improving the resistance to pathogens in livestock production. Probiotic lactic acid bacteria represent an alternative for this objective. In this study,
Ryusuke Ohgi, Sudeb Saha, Sudeb Saha, Binghui Zhou, Binghui Zhou, Taiga Sakuma, Mitsuki Sakurai, Yuhka Nakano, Fu Namai, Fu Namai, Wakako Ikeda-Ohtsubo, Wakako Ikeda-Ohtsubo, Yoshihito Suda, Keita Nishiyama, Keita Nishiyama, Julio Villena, Julio Villena, Haruki Kitazawa, Haruki Kitazawa   +18 more
doaj   +2 more sources

Therapeutic interaction of systemically-administered mesenchymal stem cells with peri-implant mucosa.

PLoS ONE, 2014
ObjectivesThe objective of this study was to investigate the effect of systemically transplanted mesenchymal stem cells (MSCs) on the peri-implant epithelial sealing around dental implants.Materials and methodsMSCs were isolated from bone marrow of donor
Ryosuke Kondo, Ikiru Atsuta, Yasunori Ayukawa, Takayoshi Yamaza, Yuri Matsuura, Akihiro Furuhashi, Yoshihiro Tsukiyama, Kiyoshi Koyano   +7 more
doaj   +2 more sources