Results 1 to 10 of about 11,131 (244)
Targeted knockdown of Piezo1 in synovial macrophages attenuates osteoarthritis development [PDF]
Journal of Orthopaedic TranslationObjective: Osteoarthritis (OA) is a prevalent degenerative joint disease worldwide. Emerging therapies targeting the crosstalk between immune/inflammatory cells and chondrocytes have shown promise.
Zijian Yan +10 more
doaj +2 more sources
Expression of Piezo1 in the Trigeminal Neurons and in the Axons That Innervate the Dental Pulp
Frontiers in Cellular Neuroscience, 2022 Information on the neurons and axons that express the mechanosensitive channel Piezo1 and its expression in axons innervating the dental pulp may help understand the nature of the Piezo1-mediated mechanosensation and the underlying mechanism of dentin ...
Yi Sul Cho +6 more
doaj +1 more source
Journal of Innate Immunity, 2023 Piezo1, the mechanosensory ion channel, has attracted increasing attention for its essential roles in various inflammatory responses and immune-related diseases. Although most of the key immune cells in inflammatory bowel disease (IBD) have been reported
Chang Liu +7 more
doaj +1 more source
Adherent cell remodeling on micropatterns is modulated by Piezo1 channels
Scientific Reports, 2021 Adherent cells utilize local environmental cues to make decisions on their growth and movement. We have previously shown that HEK293 cells grown on the fibronectin stripe patterns were elongated.
Deekshitha Jetta +4 more
doaj +1 more source
Cancer Cell International, 2022 Background Piezo1 has been revealed to play a regulatory role in vascular development and progression of variety tumors. However, whether and how the progression of hepatocellular carcinoma (HCC) regulated by Piezo1 remains elusive.
Yi-ming Li +5 more
doaj +1 more source
TRPV4-A Missing Link Between Mechanosensation and Immunity [PDF]
, 2020 Transient receptor potential vanilloid-type 4 (TRPV4) cation channel is widely expressed in all tissues as well as in immune cells and its function as mechanosensitive Ca2+ channel seems to be conserved throughout all mammalian species. Of late, emerging
Kuebler, Wolfgang M., Michalick, Laura
core +1 more source
The Role of the Piezo1 Mechanosensitive Channel in Heart Failure
Current Issues in Molecular Biology, 2023 Mechanotransduction (MT) is inseparable from the pathobiology of heart failure (HF). However, the effects of mechanical forces on HF remain unclear. This review briefly describes how Piezo1 functions in HF-affected cells, including endothelial cells (ECs)
Weihua Yuan +2 more
doaj +1 more source
Frontiers in Physiology, 2022 Piezo1 is a membrane nonspecific cation channel involved in red blood cells (RBCs) in the regulation of their volume. Recently, it was shown that it is distributed on the RBC membrane in a nonuniform manner.
Bojan Božič +2 more
doaj +1 more source
Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance [PDF]
, 2017 Mammalian biology adapts to physical activity but the molecular mechanisms sensing the activity remain enigmatic. Recent studies have revealed how Piezo1 protein senses mechanical force to enable vascular development.
A Sabbahi +30 more
core +2 more sources
PIEZO1 expression at the glio-vascular unit adjusts to neuroinflammation in seizure conditions
Neurobiology of Disease, 2023 Mechanosensors are emerging players responding to hemodynamic and physical inputs. Their significance in the central nervous system remains relatively uncharted. Using human-derived brain specimens or cells and a pre-clinical model of mesio-temporal lobe
Valentin Garcia +13 more
doaj +1 more source