Results 11 to 20 of about 11,131 (244)

Mechanosensitive Piezo1 channels mediate renal fibrosis [PDF]

JCI Insight, 2022
Kidney fibrosis is the final common pathway of progressive kidney diseases, the underlying mechanisms of which are not fully understood. The purpose of the current study is to investigate a role of Piezo1, a mechanosensitive nonselective cation channel ...
Xiaoduo Zhao, Yonglun Kong, Baien Liang, Jinhai Xu, Yu Lin, Nan Zhou, Jing Li, Bin Jiang, Jianding Cheng, Chunling Li, Weidong Wang   +10 more
doaj   +3 more sources

Keratinocyte PIEZO1 modulates cutaneous mechanosensation [PDF]

eLife, 2022
Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile information to sensory neurons. However, the specific mechanotransducers that enable keratinocytes to respond to mechanical stimulation are unknown. Here, we found that the mechanically-gated ion channel PIEZO1 is a key keratinocyte mechanotransducer.
Alexander R Mikesell, Olena Isaeva, Francie Moehring, Katelyn E Sadler, Anthony D Menzel, Cheryl L Stucky   +5 more
openaire   +4 more sources

Optical control of PIEZO1 channels

Nature Communications, 2023
AbstractPIEZO proteins are unusually large, mechanically-activated trimeric ion channels. The central pore features structural similarities with the pore of other trimeric ion channels, including purinergic P2X receptors, for which optical control of channel gating has been previously achieved with photoswitchable azobenzenes.
Francisco Andrés Peralta, Mélaine Balcon, Adeline Martz, Deniza Biljali, Federico Cevoli, Benoit Arnould, Antoine Taly, Thierry Chataigneau, Thomas Grutter   +8 more
openaire   +3 more sources

Human PIEZO1: Removing Inactivation [PDF]

Biophysical Journal, 2013
PIEZO1 is an inactivating eukaryotic cation-selective mechanosensitive ion channel. Two sites have been located in the channel that when individually mutated lead to xerocytotic anemia by slowing inactivation. By introducing mutations at two sites, one associated with xerocytosis and the other artificial, we were able to remove inactivation. The double
Bae, Chilman, Gottlieb, Philip A., Sachs, Frederick   +2 more
openaire   +2 more sources

Microbial RNAs Pressure Piezo1 to Respond [PDF]

Cell, 2020
Serotonin production by enterochromaffin cells (ECs) is microbiota-dependent, but the mechanism of this is unknown. In this issue of Cell, Sugisawa et al. demonstrate that Piezo1 in ECs senses single-strand RNA (ssRNA) from intestinal microbiota to promote serotonin production.
Juan D, Matute, Jinzhi, Duan, Richard S, Blumberg   +2 more
openaire   +2 more sources

Piezo1 [PDF]

Channels, 2012
Piezo ion channels have been found to be essential for mechanical responses in cells. These channels were first shown to exist in Neuro2A cells, and the gene was identified by siRNAs that diminished the mechanical response. Piezo channels are approximately 2500 amino acids long, have between 24-32 transmembrane regions, and appear to assemble into ...
Gottlieb, Philip A., Sachs, Frederick
openaire   +2 more sources

“Iron”ing out hemophagocytosis through PIEZO1

Cell, 2021
In this issue of Cell, Ma et al. reveal a mechanistic role for PIEZO1 in iron homeostasis through molecular genetic mouse studies. They also demonstrate implications for human iron overload and deficiency syndromes, susceptibility to malarial infection, and red blood cell turnover in persons of African ancestries.
Neil A, Hanchard, Ambroise, Wonkam
openaire   +2 more sources

Piezo1-Mediated Mechanotransduction: Orchestrating the Dynamic Response of Podocytes and Parietal Epithelial Cells to Mechanical Stress. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim The glomerulus is a specialized microvascular unit that filters plasma through the coordinated function of podocytes and parietal epithelial cells (PECs). From this perspective, the glomerulus functions like a living hydrogeological filtration system.
Melica ME, Antonelli G, Peired AJ, Lasagni L.   +3 more
europepmc   +2 more sources

PIEZO1 Channels Modulate the Small Extracellular Vesicle Release in C2C12 Cells. [PDF]

J Cell Physiol
ABSTRACT PIEZO1 are mechanically‐activated ion channels expressed in many cell types. Their pharmacological activation by the selective agonist Yoda1 has been reported to favor skeletal muscle regeneration by controlling the fate of myogenic precursors cells, but the underlying mechanisms remain largely unknown.
Annalisa B, Ru ZW, Laura SS, Alessia N, Anna F, Marianna L, Marina S, Griffoni A, William RK, Giulio T, Paola L, Agenor L.   +11 more
europepmc   +2 more sources

Mechanosensitive Ion Channel PIEZO1 Suppresses BMP2-Induced Ossification of the Annulus Fibrosus Cells. [PDF]

JOR Spine
This study aimed to elucidate the function of PIEZO1in AF cells under mechanical stimulation. Low‐magnitude cyclictensile strain (CTS, 2%) suppressed osteogenic marker expression. Pharmacological activation of PIEZO1 using Yoda1 mimics the effects oflow‐strain CTS.
Shitozawa H, Nakamichi R, Yoshida A, Ueda M, Saito T, Uotani K, Oda Y, Takatori R, Yamashita K, Ozaki T.   +9 more
europepmc   +2 more sources