Results 21 to 30 of about 11,131 (244)

Endothelial Piezo1: Life depends on it [PDF]

Channels, 2015
Endothelial cells are fundamental to almost all physiology: foundation stones of an ancient vascular system, essential for the development and survival of animals.
Jing, Li, Bing, Hou, David J, Beech
openaire   +2 more sources

Prolonged Piezo1 Activation Induces Cardiac Arrhythmia

International Journal of Molecular Sciences, 2023
The rhythmical nature of the cardiovascular system constantly generates dynamic mechanical forces. At the centre of this system is the heart, which must detect these changes and adjust its performance accordingly. Mechanoelectric feedback provides a rapid mechanism for detecting even subtle changes in the mechanical environment and transducing these ...
Laura Rolland, Angelo Giovanni Torrente, Emmanuel Bourinet, Dounia Maskini, Aurelien Drouard, Philippe Chevalier, Chris Jopling, Adele Faucherre   +7 more
openaire   +2 more sources

Contribution of Piezo2 to endothelium-dependent pain. [PDF]

, 2015
BackgroundWe evaluated the role of a mechanically-gated ion channel, Piezo2, in mechanical stimulation-induced enhancement of hyperalgesia produced by the pronociceptive vasoactive mediator endothelin-1, an innocuous mechanical stimulus-induced ...
Bogen, Oliver, Ferrari, Luiz F, Green, Paul, Levine, Jon D   +3 more
core   +2 more sources

Piezo1 integration of vascular architecture with physiological force [PDF]

, 2014
The mechanisms by which physical forces regulate endothelial cells to determine the complexities of vascular structure and function are enigmatic¹⁻⁵. Studies of sensory neurons have suggested Piezo proteins as subunits of Ca²⁺-permeable non-selective ...
Adam J. Hyman, AK Olsson, Alexander Bruns, Alicia Sedo, B Coste, B Coste, Baptiste Rode, BD Johnson, BD Matthews, Bing Hou, BJ McHugh, BL Langille, C Bae, C Bae, C Hahn, CM Warboys, D Conway, David J. Beech, Deborah A. L. Carter, E Tzima, F Babaei, Helen Imrie, Huang Da W, Hyejeong R. Kim, J Ando, Jan Bilton, Jing Li, JJ Chiu, JL Balligand, JL Lucitti, JM Dolan, JR van Beijnum, JR Wiśniewski, JS Arthur, Justin F. X. Ainscough, JW Song, K Yamamoto, K. Raj Prasad, Katsuhiko Muraki, Lesley A. Wilson, Lynn McKeown, Marc A. Bailey, Mark T. Kearney, MC Lebart, Melanie J. Ludlow, Nadira Y. Yuldasheva, Paul Ajuh, Paul C. Evans, R Rezakhaniha, R Zarychanski, Richard M. Cubbon, Richard S. Young, S Brakemeier, S Li, Sarka Tumova, SE Kim, T Mammoto, T Miyazaki, T. Neil Dear, TE Thingholm, V Hartmannsgruber, WA AbouAlaiwi, X Zhuang, Yasser Majeed, Zhaojun Fu   +64 more
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The Piezo1 hypothesis of renal anemia

FASEB BioAdvances, 2022
AbstractErythropoietin deficiency is an extensively researched cause of renal anemia. The etiology and consequences of shortened red blood cell (RBC) life span in chronic kidney disease (CKD) are less well understood. Traversing capillaries requires RBC geometry changes, a process enabled by adaptions of the cytoskeleton.
Peter Kotanko, David J. Jörg, Nadja Grobe, Christoph Zaba   +3 more
openaire   +3 more sources

Yoda1 Activates Piezo1 in Vitro to Simulate the Upregulation of Piezo1 in the Infected Brain: Piezo1 Participates in the Immune Activation of Microglia. [PDF]

, 2021
Abstract Aim: The expression of Piezo1 in reactive glial cells in the peripherally infected patient's brain was upregulated. This study aimed to determine whether Piezo1 is involved in the immune activation of microglial cells induced by bacterial lipopolysaccharides.Materials and methods: BV2 cells were used as a model of brain microglia.
Heguo Luo, Hailin Liu, Wengong Bian, Bochao Chen, Dongxia Yang, Mingmin Yang   +5 more
openaire   +1 more source

Mechanosensing is critical for axon growth in the developing brain. [PDF]

, 2016
During nervous system development, neurons extend axons along well-defined pathways. The current understanding of axon pathfinding is based mainly on chemical signaling.
A Kalous, A Kostic, A Tamada, A Walz, A Wizenmann, AF Christ, Amelia J Thompson, AP Balgude, Asha Dwivedy, B Coste, B Coste, BC Isenberg, Bollmann, BS Elkin, BS Elkin, CB Chien, CE Chan, Christine E Holt, CM Lo, D Koch, DA Sholl, David E Koser, DE Koser, DS Campbell, Eva K Pillai, FX Jiang, G Xu, Graham K Sheridan, H Hertz, Hanno Svoboda, J Li, J Swift, J Weickenmeier, JL Hutter, Jochen Guck, K Atkinson-Leadbeater, K Franze, K Franze, K Franze, K Franze, K Franze, K Pogoda, K Shibasaki, KM Leung, Kristian Franze, L Erskine, LA Flanagan, Luciano da F Costa, M Iwashita, M Piper, M Tessier-Lavigne, Matheus Viana, MM Pathak, P Moshayedi, P Weiss, PA Gottlieb, PC Georges, PC Kerstein, QY Zhang, RE Mahaffy, RW Sperry, S Kanekar, S Majkut, Sarah K Foster, SE Kim, SW Moore, T Betz, T Das, T Singh, VH Höpker, W Guan   +70 more
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An approach to familial lymphoedema. [PDF]

, 2017
Lymphoedema is the build-up of lymphatic fluid leading to swelling in the tissues. Most commonly it affects the peripheries. Diagnosis is based on clinical assessment and imaging with lymphoscintigraphy. Treatment is supportive with compression garments,
Atton, Brice, Joyce, Keppler-Noreuil, Stemmer   +4 more
core   +1 more source

Piezo1 Channels Are Inherently Mechanosensitive

Cell Reports, 2016
The conversion of mechanical force to chemical signals is critical for many biological processes, including the senses of touch, pain, and hearing. Mechanosensitive ion channels play a key role in sensing the mechanical stimuli experienced by various cell types and are present in organisms from bacteria to mammals.
Syeda, R, Florendo, MN, Cox, CD, Kefauver, JM, Santos, JS, Martinac, B, Patapoutian, A   +6 more
openaire   +4 more sources

Piezo1 activates non-canonical EGFR endocytosis and signaling

Science Advances, 2022
SummaryEGFR-ERK signaling controls cell cycle progression during development, homeostasis, and disease. Both the soluble extracellular ligand, EGF, and mechanical inputs like matrix stiffness, cell adhesion, or stretch activate EGFR-ERK signaling. However, the molecules transducing mechanical forces into EGFR signaling remain unidentified.
Carlos Pardo-Pastor, Jody Rosenblatt
openaire   +3 more sources