Results 51 to 60 of about 11,131 (244)

Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity [PDF]

, 2016
The skin is equipped with specialized mechanoreceptors that allow the perception of the slightest brush. Indeed, some mechanoreceptors can detect even nanometer-scale movements.
Bali, KK, Bégay, V, Estebanez, L, Fleischer, R, Gök, C, Haucke, V, Hoffmann, D, Kuner, R, Kühnemund, J, Lampe, A, Lapatsina, L, Lewin, GR, Moroni, M, Neuenschwander, M, Picci, C, Pifferi, S, Poole, K, Poulet, JFA, Schmoranzer, J, Smith, ESJ, Specker, E, von Kries, JP, Walcher, J, Wetzel, C   +23 more
core   +3 more sources

Oxidative Modulation of Piezo1 Channels

Redox Biology
Emerging evidence suggests that mechanosensitive Piezo1 channels play a role in the pathomechanism of various disorders. However, the mechanisms by which accumulating pathologies regulate Piezo1 activation remain unclear. Oxidative stress, a common feature of neurodegenerative diseases, is associated with generation of reactive oxygen species (ROS ...
Novosolova N., Braidotti N., Patinen T., Laitinen T., Ciubotaru C., Huttunen K. M., Levonen A. L., Cojoc D., Giniatullin R., Malm T.   +9 more
openaire   +3 more sources

Piezo1 deletion mitigates diabetic cardiomyopathy by maintaining mitochondrial dynamics via ERK/Drp1 pathway

Cardiovascular Diabetology
Objective Increasing evidence highlights the critical role of Piezo1 in cardiovascular diseases, with its expression upregulated in diabetic heart. However, the involvement of Piezo1 in the pathogenesis of diabetic cardiomyopathy (DCM) remains unclear ...
Weipin Niu, Xin Liu, Bo Deng, Tianying Hong, Cuifen Wang, Yameng Yan, Jiali Liu, Yuehua Jiang, Jing Li   +8 more
doaj   +1 more source

Recent advances in our understanding of the structure and function of more unusual cation channels. [PDF]

, 2019
As their name implies, cation channels allow the regulated flow of cations such as sodium, potassium, calcium, and magnesium across cellular and intracellular membranes.
Brown, Brandon M, Nguyen, Hai M, Wulff, Heike   +2 more
core   +1 more source

PRAS40 suppresses atherogenesis through inhibition of mTORC1-dependent pro-inflammatory signaling in endothelial cells [PDF]

, 2019
Endothelial pro-inflammatory activation plays a pivotal role in atherosclerosis, and many pro-inflammatory and atherogenic signals converge upon mechanistic target of rapamycin (mTOR).
Althoff, Till F., Burghaus, Jana, Cao Ho, Thanh, Jürgensen, Lonny, Kamuf-Schenk, Verena, Katus, Hugo A., Kiper, Leon, Krull, Alexandros, Riechert, Eva, Schecker, Johannes, Stangl, Karl, Stangl, Verena, Völkers, Mirko, Wöltje, Kerstin, Zhang, Kevin Sun   +14 more
core   +1 more source

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min, Seon Min Kim, Yeonseok Chung, Bo Kyung Koo, Yun Pyo Kang, Won Kim, Ja Hyun Koo   +9 more
wiley   +1 more source

Piezo1 Is Required for Myoblast Migration and Involves Polarized Clustering in Association with Cholesterol and GM1 Ganglioside

Cells, 2023
A specific plasma membrane distribution of the mechanosensitive ion channel Piezo1 is required for cell migration, but the mechanism remains elusive. Here, we addressed this question using WT and Piezo1-silenced C2C12 mouse myoblasts and WT and Piezo1-KO
Juliette Vanderroost, Thibaud Parpaite, Noémie Avalosse, Patrick Henriet, Christophe E. Pierreux, Joseph H. Lorent, Philippe Gailly, Donatienne Tyteca   +7 more
doaj   +1 more source

Stimulation of Piezo1 by mechanical signals promotes bone anabolism [PDF]

, 2019
Mechanical loading, such as caused by exercise, stimulates bone formation by osteoblasts and increases bone strength, but the mechanisms are poorly understood.
Almeida, Maria, Han, Li, Li, Xuehua, Mannen, Erin, Nookaew, Intawat, Silva, Matthew J, Xiong, Jinhu   +6 more
core   +1 more source

EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis. [PDF]

, 2016
Hydrops fetalis describes fluid accumulation in at least 2 fetal compartments, including abdominal cavities, pleura, and pericardium, or in body tissue. The majority of hydrops fetalis cases are nonimmune conditions that present with generalized edema of
Alexander Hoischen, Andres Vicente, Bellini, Christian Gilissen, Christina Karapouliou, Elisavet Fotiou, Fotiou, Giles Atton, Glen Brice, Heather Jeffery, Ines Martinez-Corral, John W. Wiseman, Kjell Petersen, Kristiana Gordon, Marianne Wedin, Michael A. Simpson, Michael P. Snyder, Peter S. Mortimer, Pia Ostergaard, Rita Holdhus, Rozen, Sahar Mansour, Shin Lin, Silvia Martin-Almedina, Siren Berland, Stanley G. Rockson, Steve Jeffery, Taija Makinen, Zhang   +28 more
core   +1 more source

Allogeneic Immune Cell Perfusion Inhibits the Growth of Vascularized 3D In Vitro Tumor Models, Induces Vascular Regression and Desmoplasia, but Promotes Tumor Cell Invasion

Advanced Science, EarlyView.
This study presents a vascularized 3D tumor model to investigate immune–stromal–tumor interactions under allogeneic PBMC perfusion. While immune cells induced tumor shrinkage, they also promoted vascular regression, stromal activation, and cancer cell invasion.
Alexandra Raab, Rasika Daware, Marcelo A. Szymanski de Toledo, Oskar Weber, Dimitris Kapsokalyvas, Twan Lammers, Horst Fischer, Federica De Lorenzi, Fabian Kiessling   +8 more
wiley   +1 more source