Results 91 to 100 of about 5,132 (198)
PIEZO2‐dependent rapid pain system in humans and mice
, 2023 SummaryThe PIEZO2 ion channel is critical for transducing light touch into neural signals but is not considered necessary for transducing acute pain in humans. Here, we discovered an exception – a form of mechanical pain evoked by hair pulling. Based on observations in a rare group of individuals with PIEZO2 deficiency syndrome, we demonstrated that ...
Otmane Bouchatta +28 more
openaire +2 more sources
Advanced Science, Volume 13, Issue 13, 3 March 2026.An ultralight, multilayer anisotropic tactile sensor—an artificial Pacinian corpuscle—exhibits ultrahigh tangential sensitivity (1022 kPa−1) and spatiotemporal sensing. It discriminates static, sliding, and rolling contacts, detects incipient stick–slip via high‑frequency signatures, and enhances robotic touch (100%/98.18% accuracy for active/passive ...
Jinghui Wang +12 more
wiley +1 more source
PIEZO1 Channels Modulate the Small Extracellular Vesicle Release in C2C12 Cells
Journal of Cellular Physiology, Volume 241, Issue 3, March 2026.ABSTRACT PIEZO1 are mechanically‐activated ion channels expressed in many cell types. Their pharmacological activation by the selective agonist Yoda1 has been reported to favor skeletal muscle regeneration by controlling the fate of myogenic precursors cells, but the underlying mechanisms remain largely unknown.
Bernareggi Annalisa +11 more
wiley +1 more source
The changing landscape of membrane protein structural biology through developments in electron microscopy [PDF]
, 2016 Membrane proteins are ubiquitous in biology and are key targets for therapeutic development. Despite this, our structural understanding has lagged behind that of their soluble counterparts.
Albuisson J +7 more
core +1 more source
Intraluminal chloride regulates lung branching morphogenesis: involvement of PIEZO1/PIEZO2
Respiratory Research, 2023 Background Clinical and experimental evidence shows lung fluid volume as a modulator of fetal lung growth with important value in treating fetal lung hypoplasia.
Ana N. Gonçalves +3 more
doaj +1 more source
JOR SPINE, Volume 9, Issue 1, March 2026.This study aimed to elucidate the function of PIEZO1in AF cells under mechanical stimulation. Low‐magnitude cyclictensile strain (CTS, 2%) suppressed osteogenic marker expression. Pharmacological activation of PIEZO1 using Yoda1 mimics the effects oflow‐strain CTS.
Hisakazu Shitozawa +9 more
wiley +1 more source
Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4 [PDF]
Channels, 2017 Enterochromaffin (EC) cells are the primary mechanosensors of the gastrointestinal (GI) epithelium. In response to mechanical stimuliEC cells release serotonin (5-hydroxytryptamine; 5-HT). The molecular details ofEC cell mechanosensitivity are poorly understood.
Constanza, Alcaino +4 more
openaire +2 more sources
Andrology, Volume 14, Issue 3, Page 661-701, March 2026.Abstract Background Penile sexual sensation relies on intricate neural structures that remain incompletely characterized. Immunohistological insights into their development and organization can enhance understanding of penile neuroanatomy and function, while optimizing surgical outcomes.
Alfonso Cepeda‐Emiliani +6 more
wiley +1 more source
Mecanosensibilidad mediada por PIEZO2
, 2022 Tesis doctoral por compendio de ...
openaire +1 more source
Human phenotypes caused by PIEZO1 mutations; one gene, two overlapping phenotypes? [PDF]
, 2018 PIEZO1 is a large mechanosensitive ion channel protein. Diseases associated with PIEZO1 include autosomal recessive Generalised Lymphatic Dysplasia of Fotiou (GLDF) and autosomal dominant Dehydrated Hereditary Stomatocytosis with or without ...
Albuisson +30 more
core +1 more source