Results 81 to 90 of about 4,014 (160)

Sensory Biology: It Takes Piezo2 to Tango [PDF]

, 2014
SummaryA trio of papers has resolved an outstanding controversy regarding the function of Merkel cells and their afferent nerve fiber partners. Merkel cells sense mechanical stimuli (through Piezo2), fire action potentials, and are sufficient to activate
Vásquez, Valeria, Scherrer, Gregory, Goodman, Miriam B.   +2 more
core   +1 more source

Infiltrated Macrophages Aggravate TMJOA Chronic Pain via Piezo2 in IB4+-TG Neurons [PDF]

Objective: Recent research indicates that macrophages in ganglia are linked to chronic pain, with Piezo2 ion channels playing a key role in pain sensation.
Chen, Ruiming, Zheng, Liwu, Liu, Yu, Jia, Xueke, Ke, Jin, Liu, Xin, Zhu, Taomin, Ma, Xiaohan, Feng, Yaping, Li, Huimin   +9 more
core   +1 more source

Chondrocyte-specific knockout of Piezo1 and Piezo2 protects against post-traumatic osteoarthritis structural damage and pain in mice

Arthritis Research & Therapy
Background Osteoarthritis (OA) is a debilitating joint disease characterized by cartilage degeneration, synovial inflammation, and bone remodeling, with limited therapeutic options targeting the underlying pathophysiology.
Erica V. Ely, Kristin L. Lenz, Sophie G. Paradi, Seth Ack, Abraham Behrmann, Sarah Dunivan, Lauryn Braxton, Wolfgang Liedtke, Yong Chen, Kelsey H. Collins, Farshid Guilak   +10 more
doaj   +1 more source

Trigeminal nerve root compression induced neuroinflammatory response promotes mechanical allodynia through the CGRP/SP-Piezo2 axis via Ca2+ signaling

Cellular & Molecular Biology Letters
Trigeminal neuralgia (TN) is one of the most severe types of neuropathic pain, but its pathological mechanisms remain unknown. In this study, we identified a unique neuroinflammatory response induced by chronic compression of trigeminal root entry zone ...
Xinyue Liao, Zhaoke Luo, Feng Huang, Yiqian Wang, Zhangying Zeng, Weihang Liao, Yating Ou, Xuemei Wu, Feng Wang, Daoshu Luo   +9 more
doaj   +1 more source

A Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist Birds

Cell Reports, 2019
Summary: A major challenge in biology is to link cellular and molecular variations with behavioral phenotypes. Here, we studied somatosensory neurons from a panel of bird species from the family Anatidae, known for their tactile-based foraging behavior ...
Eve R. Schneider, Evan O. Anderson, Viktor V. Feketa, Marco Mastrotto, Yury A. Nikolaev, Elena O. Gracheva, Sviatoslav N. Bagriantsev   +6 more
doaj   +1 more source

TMEM150C/Tentonin3 Is a Regulator of Mechano-gated Ion Channels

Cell Reports, 2018
Summary: Neuronal mechano-sensitivity relies on mechano-gated ion channels, but pathways regulating their activity remain poorly understood. TMEM150C was proposed to mediate mechano-activated current in proprioceptive neurons. Here, we studied functional
Evan O. Anderson, Eve R. Schneider, Jon D. Matson, Elena O. Gracheva, Sviatoslav N. Bagriantsev   +4 more
doaj   +1 more source

Glans clitoris innervation: PIEZO2 and sexual mechanosensitivity

, 2020
The clitoris is a leading player in female sexual arousal, if not the main protagonist. Despite this role, studies performed on this structure with specific neuroanatomical techniques are few.
Vega, Jose Antonio, Vega, José A., García-Suárez, Olivia, Olivia García‐Suárez, Cárcaba García, Lucía, García Mesa, Yolanda, Cobo, Ramón, Jorge Feito, Feito, Jorge, Coronado, César A., Yolanda García‐Mesa, César Coronado, García-Mesa, Yolanda, García‐Suárez, Olivia, Vega Álvarez, José Antonio, García Suárez, Olivia, Martín‐Cruces, José, Coronado, C., Lucía Cárcaba, Jorge García‐Piqueras, Cárcaba, Lucía, Martín-Cruces, José, García‐Piqueras, Jorge, José Martín‐Cruces, Cobo Díaz, Ramón, Coronado, César, García Piqueras, Jorge, García-Piqueras, Jorge, Ramón Cobo, García‐Mesa, Yolanda, José A. Vega, Martín Cruces, J.   +31 more
core   +1 more source

mpECs with high Piezo2 expression promote fracture healing by driving angiogenesis through the Notch signaling pathway

BMC Musculoskeletal Disorders
Fractures will impair or disrupt angiogenesis, resulting in delayed union or non-union. Exploring angiogenic signaling molecules and related pathways can promote fracture healing.
Lingfeng He, Fanyong Gong, Jiangyong Wang, Yi Huang, Haifeng Wang   +4 more
doaj   +1 more source

Expression patterns of mechanosensitive ion channel PIEZOs in irreversible pulpitis

BMC Oral Health
Background Mechanosensitive ion channel PIEZOs have been widely reported to involve inflammation and pain. This study aimed to clarify expression patterns of PIEZOs and their potential relations to irreversible pulpitis. Materials and methods Normal pulp
Wenying Yang, Lu Lin, Shucheng Hu, Bin Jiang, Ruhan Yang, Weijun Yu, Jiaqi Tang, Dan Zhao, Yuting Gu, Min Jin, Jin Li, Eryi Lu   +11 more
doaj   +1 more source

Role of Piezo2 in Schwann Cell Volume Regulation and Its Impact on Neurotrophic Release Regulation

Cellular Physiology and Biochemistry
Background/Aims: Tactile perception relies on mechanoreceptors and nerve fibers, including c-fibers, Aβ-fibers and Aδ-fibers. Schwann cells (SCs) play a crucial role in supporting nerve fibers, with non-myelinating SCs enwrapping c-fibers and myelinating
Chawapun Suttinont, Moe Tsutsumi, Tomohiro Numata, Kaori Sato-Numata, Mamiko Yano, Katsuyuki Maeno   +5 more
doaj   +1 more source