Results 71 to 80 of about 4,014 (160)

Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies

The Journal of Physiology, EarlyView.
Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu, Rachel E. A. Smyth, Aishwarya Prakash, Thomas Iskratsch   +3 more
wiley   +1 more source

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

Progressive Irreversible Proprioceptive Piezo2 Channelopathy-Induced Lost Forced Peripheral Oscillatory Synchronization to the Hippocampal Oscillator May Explain the Onset of Amyotrophic Lateral Sclerosis Pathomechanism

Cells
Amyotrophic lateral sclerosis (ALS) is a mysterious lethal multisystem neurodegenerative disease that gradually leads to the progressive loss of motor neurons.
Balázs Sonkodi
doaj   +1 more source

Low‐threshold cutaneous mechanoreceptors on the foot sole have enhanced sensitivity when skin temperature is elevated

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of microneurography recordings used to examine the effects of local skin heating on cutaneous mechanoreceptor responses in the human foot (left panel). A microelectrode inserted into a peripheral nerve records single‐unit activity from tactile afferent fibres while controlled mechanical stimuli are applied ...
Erika E. Howe, Michael Apollinaro, Joanna Reeves, Christopher Nester, Leah R. Bent   +4 more
wiley   +1 more source

Weighted Single‐Step GWAS Reveals Genetic Mechanisms Underlying Pregnancy Loss in Early Nellore Heifers

Animal Genetics, Volume 57, Issue 5, October 2026.
ABSTRACT Pregnancy loss (PL) affects reproductive efficiency in beef cattle, yet its genetic architecture remains poorly understood in Bos indicus populations. Here, PL was defined as failure from pregnancy diagnosis to calving, capturing a window approximately 60 days after the breeding season.
Flávia C. Bis, Nedenia Bonvino Stafuzza, Elisângela Chicaroni de Mattos, Angélica Simone Cravo Pereira, José Bento Sterman Ferraz, Fernando Baldi, Sabrina T. Amorim   +6 more
wiley   +1 more source

Comprehensive analysis of mRNA expression of Piezo1 and Piezo2 in tumor samples and their prognostic implications in gastric cancer

Discover Oncology
Background This study aims to investigate the expression pattern and clinical significance of Piezo1 and Piezo2 in various cancers, focusing on gastric cancer (GC).
Tong Liang, Junhong Wang, Zhong Yang, Ronglong Zhang   +3 more
doaj   +1 more source

Author response: Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons [PDF]

, 2018
Piezo2 ion channels are critical determinants of the sense of light touch in vertebrates. Yet, their regulation is only incompletely understood. We recently identified myotubularin related protein-2 (Mtmr2), a phosphoinositide (PI) phosphatase, in the ...
Rehfeldt, Florian, Kudryasheva, Galina, Narayanan, P., Gomez-Varela, David, Pratibha Narayanan, Kudryasheva, G., Lechner, Stefan G, Florian Rehfeldt, Narayanan, Pratibha, Taberner, Francisco J, Schmidt, Manuela, Meike Hütte, Manuela Schmidt, Stefan G Lechner, Hütte, Meike, Schmidt, M., Taberner, F., Gomez-Varela, D., Rehfeldt, F., David Gomez-Varela, Francisco J Taberner, Galina Kudryasheva, Hütte, M., Lechner, S., Schmodt, Manuela   +24 more
core   +1 more source

Immunohistochemical Detection of PIEZO Ion Channels in the Human Carotid Sinus and Carotid Body

Biomolecules
The carotid sinus and the carotid body are major peripheral chemo- and baro(mechano)receptors that sense changes in arterial wall pressure and in oxygen, carbon dioxide, and pH in arterial blood.
Elda Alba, Yolanda García-Mesa, Ramón Cobo, Patricia Cuendias, José Martín-Cruces, Iván Suazo, Graciela Martínez-Barbero, José A. Vega, Olivia García-Suárez, Teresa Cobo   +9 more
doaj   +1 more source

PIEZO2 in tumors: from mechanobiological switches to activity-targeted therapies

Journal of Experimental & Clinical Cancer Research
Mechanosensitive ion channel PIEZO2 translates microenvironmental forces into Ca²⁺-dependent signals that shape tumor behavior. Across cancers, PIEZO2 exhibits context-dependent roles, with evidence for both pro- and anti-tumor functions, depending on ...
Dan-xia Huang, Qiu-zhi Zhou, Hong-mei Luo, Mohammad Nasb, Yi-zhou Liu, Yu-jie Yang, Hong Chen   +6 more
doaj   +1 more source

Prognostic Evaluation of Piezo2 Channels in Mammary Gland Carcinoma [PDF]

In the last decade, a group of Ca2+ channels called Piezo were discovered, demonstrating a decisive role in the cellular response to mechanical stimuli and being essential in the biological behavior of cells regarding the extracellular compartment ...
Rodrigues-Françoso, Aline, Martín-Sanz, Raquel, Malmierca-González, Sandra, Sandra Malmierca-González, Aline Rodrigues-Françoso, Francisco Javier García-Alonso, García-Alonso, Francisco Javier, Rocío Salazar-Blázquez, Jorge Feito, Olivia García-Suárez, Gómez-Muñoz, María Asunción, Raquel Martín-Sanz, Salazar-Blázquez, Rocío, Feito, Jorge, María Asunción Gómez-Muñoz, García-Mesa, Yolanda, García Suárez, Olivia, Yolanda García-Mesa   +17 more
core   +1 more source