Results 61 to 70 of about 4,014 (160)
BMEMat, EarlyView.This study reports a novel Zr58Cu25Al14Nb3 bulk metallic glass that possesses high mechanical strength and low elastic modulus, which further promotes efficient mechanotransduction and significantly improves peri‐implant bone quality upon cyclic occlusal loading.
Yunshu Wu +10 more
wiley +1 more source
Mechanically-gated currents in mouse sensory neurons lacking PIEZO2 [PDF]
Touch sensation starts with the opening of mechanically-gated activated ion channels at neuroglial endings of mechanoreceptors in the skin. The function of around half of low threshold mechanoreceptors is dependent on the presence of the mechanically ...
Sánchez-Carranza, Oscar +7 more
core +1 more source
Is the Sex Difference a Clue to the Pathomechanism of Dry Eye Disease? Watch out for the NGF-TrkA-Piezo2 Signaling Axis and the Piezo2 Channelopathy [PDF]
, 2022 Dry eye disease (DED) is a multifactorial disorder with recognized pathology, but not entirely known pathomechanism. It is suggested to represent a continuum with neuropathic corneal pain with the paradox that DED is a pain-free disease in most cases ...
Resch, Miklós D +2 more
core +1 more source
Prenatal Diagnosis, EarlyView.ABSTRACT Objective To evaluate the diagnostic yield of integrated molecular autopsy (IMA) by combining deep post‐mortem phenotyping with exome (ES) and targeted genome sequencing (GS) for prenatally detected anomalies. Method This retrospective study evaluated 28 perinatal cases (22 fetuses, six neonates) with severe anomalies, normal first‐tier ...
Sihem Darouich +6 more
wiley +1 more source
The Piezo2 ion channel is mechanically activated by low-threshold positive pressure [PDF]
, 2019 Recent parallel studies clearly indicated that Merkel cells and the mechanosensitive piezo2 ion channel play critical roles in the light-touch somatosensation.
Kim, Jae G. +9 more
core +1 more source
Arterial Baroreceptors Sense Blood Pressure through Decorated Aortic Claws
Cell Reports, 2019 Summary: Mechanosensory neurons across physiological systems sense force using diverse terminal morphologies. Arterial baroreceptors are sensory neurons that monitor blood pressure for real-time stabilization of cardiovascular output.
Soohong Min +6 more
doaj +1 more source
Smart Molecules, EarlyView.Nonthermal ultrasound transforms acoustic energy into diverse therapeutic bioeffects through cavitation, mechanical stimulation, and physicochemical activation. This review discusses how acoustic parameters, biological mechanisms, and responsive materials interact to influence nonthermal ultrasound‐enabled cancer therapies. Mechanism‐guided engineering
Liu Wang +5 more
wiley +1 more source
Peripheral targets for neuropathic pain
British Journal of Pharmacology, EarlyView.Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour +3 more
wiley +1 more source
PIEZO2, a mechanosensor in the urinary bladder
, 2021 What did the study show? Marshall et al. first showed that PIEZO2 is expressed in >70% of umbrella cells, which constitute the innermost layer of the urothelium, and in >80% of afferent neurons.
Gailly, Philippe +4 more
core +1 more source
Mechanical sensitization of sensory afferents after passive transfer of fibromyalgia IgG
The Journal of Physiology, EarlyView.Abstract figure legend In addition to widespread pain and fatigue, people with fibromyalgia (FM) experience sensory abnormalities and report lingering, painful sensations after touch or mechanical probing of the skin. Administration of IgG purified from FM patients to mice transfers symptoms and signs of FM.
Mathilde R. Israel +5 more
wiley +1 more source