Results 91 to 100 of about 4,014 (160)

Merkel cells and Meissner's corpuscles in human digital skin display Piezo2 immunoreactivity

, 2017
The transformation of mechanical energy into electrical signals is the first step in mechanotransduction in the peripheral sensory nervous system and relies on the presence of mechanically gated ion channels within specialized sensory organs called ...
García-Mesa Y., Feito J., García B., Cobo J., García-Suárez O., Vega J.A., García-Piqueras J., Cabo R.   +7 more
core   +1 more source

Piezo Mediates the Mechanosensation and Injury-Repair of Pulpo-Dentinal Complex

International Dental Journal
Objectives: The aim of this research was to investigate the functions of Piezo channels in dentin defect, including mechanical signalling and odontoblast responses.
Xiaoqiao Xu, Yi Guo, Peiqi Liu, Hui Zhang, Yijie Wang, Zhen Li, Yukun Mei, Lin Niu, Ruirui Liu   +8 more
doaj   +1 more source

Piezo in the eye: expression, distribution and roles in ocular diseases

Frontiers in Physiology
Piezo channels are currently known to be the most sensitive molecular mechanoreceptors. Piezo can respond to membrane tension, sag, shear force, tensile and other mechanical stimuli, produces fast inactivation, small conductance, and low threshold ...
Li Zhu, Shouyan Ren, Shuang He, Meifang Liu, Fei Hou   +4 more
doaj   +1 more source

Genetic and clinical spectrum of PIEZO2-related disorders: insights from a multicenter study of 26 patients

PIEZO2 is a mechanosensitive ion channel essential for somatosensation, including proprioception, touch and interoception, enabling the detection of external and internal mechanical stimuli.
Cetinoglu, Yusuf Kenan, Degerliyurt, Aydan, Akinci, Gulcin, Polat, Ipek, Ceylan, Ahmet Cevdet, Turkdogan, Dilsad, Ardicli, Didem, Karti, Omer, Elmas, Muhsin, Gunes, Ayfer Sakarya, Ozcelik, Aysima, Karakayali, Burcu, Sahan, Sonay, Komur, Mustafa, Koken, Ozlem Yayici, Aydin, Hilal, Topaloglu, Haluk, Aksoy, Ayse, Yilmaz, Sanem, ÖZTÜRK, GÜLTEN, Gerik-Celebi, Hamide Betul, Ozyilmaz, Berk, Isik, Esra, Gunay, Cagatay, Cetin, Ipek Dokurel, Tuncer, Gokcen Oz, Yis, Uluc, Karadeniz, Cem, Celik, Tamer, Onel, Ece, Temel, Sehime Gulsun, Bolat, Hilmi, Sahinoglu, Bahtiyar   +32 more
core   +2 more sources

TET3 is a regulator and can be targeted for the intervention of myocardial fibrosis

EMBO Molecular Medicine
Cardiac fibrosis contributes to adverse cardiac remodeling and loss of heart function eventually leading to heart failure (HF). Resident cardiac fibroblasts are the principal source of myofibroblasts that produce extracellular matrix proteins to mediate ...
Chenghao Zhu, Wenxuan Hong, Yuwen Zhu, Yujia Xue, Zemin Fang, Dingsheng Jiang, Yong Xu, Ming Kong   +7 more
doaj   +1 more source

Nociceptor Neurons Facilitate Orthodontic Tooth Movement via Piezo2 in Mice

Multiple sensory afferents, including mechanosensitive and nociceptive nerves, are projected to the periodontium. Peptidergic afferents expressing transient receptor potential vanilloid 1 (TRPV1), a receptor for capsaicin, mediate pain caused by ...
Nie, X., Parastooei, G., Wang, S., Kumari, S., Elnabawi, O., Pae, E.-K., Chung, M.-K., Ko, C.C., Abbasi, Y.   +8 more
core   +1 more source

Piezo2 in bladder-innervating sensory neurons contributes to regulation of contractile activity in cystitis

, 2019
<p>Overactivity of the urinary bladder constitutes one of the main symptoms in various lower urinary tract disorders and it significantly deteriorates quality of life.
Angelika Varga, Klara Matesz, Torres-Perez, Jose, Jose Torres-Perez, La Montanara, Paolo, Joe Chamberlain, Antonio Avelino, Paolo La Montanara, De Sousa Valente, Joao, Botond Gaal, Keller, Esra, Matesz, Klara, Varga, Angelika, Istvan Nagy, Chamberlain, Joe, Nagy, Istvan, Esra Keller, Gaal, Botond, Joao de Sousa Valente, Avelino, Antonio   +19 more
core   +1 more source

Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking

Military Medical Research
Background Tactile and mechanical pain are crucial to our interaction with the environment, yet the underpinning molecular mechanism is still elusive.
Man-Xiu Xie, Ren-Chun Lai, Yi-Bin Xiao, Xi Zhang, Xian-Ying Cao, Xiao-Yu Tian, An-Nan Chen, Zi-Yi Chen, Yan Cao, Xiao Li, Xiao-Long Zhang   +10 more
doaj   +1 more source

Structure-guided examination of the mechanogating mechanism of PIEZO2

, 2019
Piezo channels are mechanically activated ion channels that confer mechanosensitivity to a variety of different cell types. Piezos oligomerize as propeller-shaped homotrimers that are thought to locally curve the membrane into spherical domes that ...
Heppenstall P. A., Lechner S. G., Schrenk-Siemens K., Schaefer I., Taberner F. J., Prato V.   +5 more
core   +1 more source

Functional and distinct roles of Piezo2-mediated mechanotransduction in dental primary afferent neurons

International Journal of Oral Science
Piezo2, a mechanosensitive ion channel, serves as a crucial mechanotransducer in dental primary afferent (DPA) neurons and is potentially involved in hypersensitivity to mild mechanical irritations observed in dental patients.
Pa Reum Lee, Kihwan Lee, Ji Min Park, Shinae Kim, Seog Bae Oh   +4 more
doaj   +1 more source