Results 101 to 110 of about 5,132 (198)

Immunohistochemical Detection of PIEZO Ion Channels in the Human Carotid Sinus and Carotid Body

Biomolecules
The carotid sinus and the carotid body are major peripheral chemo- and baro(mechano)receptors that sense changes in arterial wall pressure and in oxygen, carbon dioxide, and pH in arterial blood.
Elda Alba, Yolanda García-Mesa, Ramón Cobo, Patricia Cuendias, José Martín-Cruces, Iván Suazo, Graciela Martínez-Barbero, José A. Vega, Olivia García-Suárez, Teresa Cobo   +9 more
doaj   +1 more source

Piezo1‐Mediated Mechanotransduction: Orchestrating the Dynamic Response of Podocytes and Parietal Epithelial Cells to Mechanical Stress

Acta Physiologica, Volume 242, Issue 3, March 2026.
ABSTRACT Aim The glomerulus is a specialized microvascular unit that filters plasma through the coordinated function of podocytes and parietal epithelial cells (PECs). From this perspective, the glomerulus functions like a living hydrogeological filtration system.
Maria Elena Melica, Giulia Antonelli, Anna Julie Peired, Laura Lasagni   +3 more
wiley   +1 more source

Comprehensive analysis of mRNA expression of Piezo1 and Piezo2 in tumor samples and their prognostic implications in gastric cancer

Discover Oncology
Background This study aims to investigate the expression pattern and clinical significance of Piezo1 and Piezo2 in various cancers, focusing on gastric cancer (GC).
Tong Liang, Junhong Wang, Zhong Yang, Ronglong Zhang   +3 more
doaj   +1 more source

Novel Technologies for Exploring the Skin–Brain Axis

Advanced Sensor Research, Volume 5, Issue 2, February 2026.
The skin–brain axis mediates bidirectional communication between cutaneous physiology and the nervous system, influencing sensation, inflammation, and disease. This review surveys emerging microsensor, nanosensor, and bioelectronic technologies integrated with advanced skin and neural models, highlighting multimodal, real‐time strategies to decode ...
Dahiana Mojena Medina, Francesca Santoro
wiley   +1 more source

Piezo2 mediates corneal noxious mechanssensation

, 2021
Trabajo presentado al Seminario de Unidad Neurobiología Celular y de Sistemas del Instituto de Neurociencias, celebrado online el 9 de febrero de 2021.
Fernández-Trillo, Jorge, Viana, Félix, Gomis, Ana   +2 more
openaire   +1 more source

Single-Cell RNA-seq Reveals Profound Alterations in Mechanosensitive Dorsal Root Ganglion Neurons with Vitamin E Deficiency. [PDF]

, 2019
Ninety percent of Americans consume less than the estimated average requirements of dietary vitamin E (vitE). Severe vitE deficiency due to genetic mutations in the tocopherol transfer protein (TTPA) in humans results in ataxia with vitE deficiency (AVED)
Bordbari, Matthew H, Durbin-Johnson, Blythe, Finno, Carrie J, Kang, Mincheol, Lee, Jeong H, Park, Seojin, Perez-Flores, Maria C, Peterson, Janel, Settles, Matthew, Yamoah, Ebenezer N   +9 more
core  

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2 [PDF]

, 2016
Diverse proteases cleave protease-activated receptor-2 (PAR2) on primary sensory neurons and epithelial cells to evoke pain and inflammation. Trypsin and tryptase activate PAR2 by a canonical mechanism that entails cleavage within the extracellular N ...
Barlow, N., Bron, R., Bunnett, N. W., Edgington-Mitchell, L., Fairlie, D. P., Lieu, T., Lohman, R. -J., Mclean, P., Poole, D. P., Savage, E., Zhao, P.   +10 more
core   +2 more sources

Progressive Irreversible Proprioceptive Piezo2 Channelopathy-Induced Lost Forced Peripheral Oscillatory Synchronization to the Hippocampal Oscillator May Explain the Onset of Amyotrophic Lateral Sclerosis Pathomechanism

Cells
Amyotrophic lateral sclerosis (ALS) is a mysterious lethal multisystem neurodegenerative disease that gradually leads to the progressive loss of motor neurons.
Balázs Sonkodi
doaj   +1 more source

Matching heterogeneous cohorts by projected principal components reveals two novel Alzheimer's disease‐associated genes in the Hispanic population

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) is the most common form of dementia. Studies have suggested prevalence is greater in individuals self‐identifying as Hispanic. Population‐specific results enable personalized and equitable interventions. Ethnicity as a stratifier co‐occurs with genomic inflation due to heterogeneity.
Julian Daniel Sunday Willett, Mohamad Waqas, Serhiy Naumenko, Kristina Mullin, Julian Hecker, Lars Bertram, Christoph Lange, Ioannis Vlachos, Winston Hide, Rudolph E. Tanzi, Dmitry Prokopenko   +10 more
wiley   +1 more source

Infiltrated Macrophages Aggravate TMJOA Chronic Pain via Piezo2 in IB4+-TG Neurons [PDF]

Objective: Recent research indicates that macrophages in ganglia are linked to chronic pain, with Piezo2 ion channels playing a key role in pain sensation.
Chen, Ruiming, Feng, Yaping, Jia, Xueke, Ke, Jin, Li, Huimin, Liu, Xin, Liu, Yu, Ma, Xiaohan, Zheng, Liwu, Zhu, Taomin   +9 more
core   +1 more source