Results 31 to 40 of about 5,132 (198)

Native Piezo2 Interactomics Identifies Pericentrin as a Novel Regulator of Piezo2 in Somatosensory Neurons

Journal of Proteome Research, 2016
The ability of somatosensory neurons to perceive mechanical stimuli relies on specialized mechanotransducing proteins and their molecular environment. Only recently has the identity of a major transducer of mechanical forces in vertebrates been revealed by the discovery of Piezo2.
Narayanan, P., Sondermann, J., Rouwette, T., Karaca, S., Urlaub, H., Mitkovski, M., Gomez-Varela, D., Schmidt, M.   +7 more
openaire   +5 more sources

Functional and Molecular Characterization of Mechanoinsensitive "Silent" Nociceptors. [PDF]

, 2017
Mechanical and thermal hyperalgesia (pain hypersensitivity) are cardinal signs of inflammation. Although the mechanism underlying thermal hyperalgesia is well understood, the cellular and molecular basis of mechanical hyperalgesia is poorly described ...
Arcourt, Alice, Callejo, Gerard, Hammer, Leonie, Heppenstall, Paul A, Hockley, James RF, Lechner, Stefan G, Prato, Vincenzo, Schad, Paulina, Smith, Ewan S, Taberner, Francisco J, Tazir, Bassim   +10 more
core   +4 more sources

Single-cell RNAseq reveals seven classes of colonic sensory neuron. [PDF]

, 2018
OBJECTIVE: Integration of nutritional, microbial and inflammatory events along the gut-brain axis can alter bowel physiology and organism behaviour. Colonic sensory neurons activate reflex pathways and give rise to conscious sensation, but the diversity ...
Bach, Karsten, Bulmer, David C, Callejo, Gerard, Gutteridge, Alex, Hockley, James RF, McMurray, Gordon, Smith, Ewan St John, Taylor, Toni S, Wilbrey, Anna L, Winchester, Wendy J   +9 more
core   +1 more source

Electroacupuncture Attenuates Post-Inflammatory IBS-Associated Visceral and Somatic Hypersensitivity and Correlates With the Regulatory Mechanism of Epac1–Piezo2 Axis

Frontiers in Endocrinology, 2022
Electroacupuncture (EA) is considered to have a therapeutic effect in the relief of irritable bowel syndrome (IBS)-associated visceral hypersensitivity via the reduction of the level of 5‐hydroxytryptamine (5‐HT) and 5-HT3 receptors (5-HT3R).
Jing Guo, Jing Guo, Lu Chen, Yu-hang Wang, Ya-fang Song, Zhan-hao Zhao, Ting-ting Zhao, Zhi-ying Lin, Dong-mei Gu, Yun-qi Liu, Yong-jun Peng, Li-xia Pei, Jian-hua Sun   +12 more
doaj   +1 more source

Sensory Biology: It Takes Piezo2 to Tango [PDF]

Current Biology, 2014
A trio of papers has resolved an outstanding controversy regarding the function of Merkel cells and their afferent nerve fiber partners. Merkel cells sense mechanical stimuli (through Piezo2), fire action potentials, and are sufficient to activate downstream sensory neurons.
Vásquez, Valeria, Scherrer, Gregory, Goodman, Miriam B.   +2 more
openaire   +2 more sources

Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1 [PDF]

, 2017
Osteoarthritis (OA) is characterised by progressive destruction of articular cartilage and chondrocyte cell death. Here, we show the expression of the endogenous peptide urocortin1 (Ucn1) and two receptor subtypes, CRF-R1 and CRF-R2, in primary human ...
A Rosenhouse-Dantsker, AA Caro, AE Dubin, AF Seasholtz, AK Amin, AR Amin, C Asker, C Iavazzo, C Zhu, CAM Huser, CE Combs, CR Chu, DA Lovejoy, DA Lovejoy, DK Grammatopoulos, DP Behan, E Gonzalez-Rey, EW Hillhouse, F Finger, FJ Blanco, H Muir., H Xu, H Zhao, HI Roach, I Borbiro, J Tao, J Tao, J Tao., J Vaughen, J Wu, JB Calixto, JP Urban, KM Lawrence, KM Lawrence, KM Lawrence, L Fedrizzi, L Leistad, L Volkers, M Kohno, M Sisignano, M Uzuki, MB Goldring, MH Perrin, MR Servin-Vences, N Yatugi, NY Intekhab-Alam, PP Srinivasan, R Barrett-Jolley, R Lewis, R Lewis, RF Loeser, S Hashimoto, SA Gudipaty, SN Bagriantsev, SY Hsu, T Blank, T Smani, TT Chowdhury, W Lee, WA Pedersen, WA Pedersen, XF Li, Y Huang   +62 more
core   +1 more source

Downregulation of in the Detrusor of Men With Bladder Outlet Obstruction and Its Association With Urinary Retention and Decreased Bladder Compliance [PDF]

International Neurourology Journal
Purpose Recent research has highlighted the mechanotransducer PIEZO2 as a crucial factor in lower urinary tract function, demonstrating associations with bladder compliance (BC), bladder wall thickening, and elevated bladder pressure.
Carlos Henrique Suzuki Bellucci, Thiago Souto Hemerly, Luisa Resende Tenório de Albuquerque, Ruan Pimenta, Vanessa Guimaraes Schreiter, Sabrina Thalita dos Reis, Jose de Bessa Jr, Katia Ramos Moreira Leite, Alberto Antunes, Boopathi Ettickan, William C. Nahas, Cristiano Mendes Gomes   +11 more
doaj   +1 more source

Delayed Onset Muscle Soreness and Critical Neural Microdamage-Derived Neuroinflammation

Biomolecules, 2022
Piezo2 transmembrane excitatory mechanosensitive ion channels were identified as the principal mechanotransduction channels for proprioception. Recently, it was postulated that Piezo2 channels could be acutely microdamaged on an autologous basis at ...
Balázs Sonkodi
doaj   +1 more source

Osteoarthritis year in review 2015: mechanics [PDF]

, 2015
Motivated by the conceptual framework of multi-scale biomechanics, this narrative review highlights recent major advances with a focus on gait and joint kinematics, then tissue-level mechanics, cell mechanics and mechanotransduction, matrix mechanics ...
Grodzinsky, Alan J, Varady, Nathan H.
core   +1 more source

Evidence for shear-mediated Ca2+ entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line [PDF]

, 2017
The role of mechanosensitive (MS) Ca2+-permeable ion channels in platelets is unclear, despite the importance of shear stress in platelet function. We sought to investigate the expression and functional relevance of MS channels in human platelets.
Agboh, Albuisson, Alison H. Goodall, Amisten, Andolfo, Ashour, Authi, Bae, Boyanova, Burkhart, Cahalan, Cauwenberghs, Chow, Chris I. Jones, Coste, Coste, Cox, Eisenhoffer, Gibbins, Glenn, Gnanasambandam, Gudipaty, Hartwig, Hassock, Hechler, Hofmann, Huang, Jonathan M. Gibbins, Jones, Jones, Joy R. Wright, Junt, King, Kroll, Levenson, Li, Li, Lukacs, Mahaut-Smith, Mahaut-Smith, Mahaut-Smith, Martyn P. Mahaut-Smith, Mazzucato, Miyazaki, Morris, Mountford, Nesbitt, Nesbitt, Ogura, Pathak, Prakash, Pugh, Ranade, Rolf, Schneider, Schneider, Siedlecki, Small, Soves, Spassova, Suchyna, Suchyna, Sun, Syeda, Thon, Varga-Szabo, Wang, Wollscheid, Wright, Wright, Yap, Zarychanski, Zeki Ilkan   +72 more
core   +1 more source