Results 41 to 50 of about 5,132 (198)

Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity [PDF]

, 2016
The skin is equipped with specialized mechanoreceptors that allow the perception of the slightest brush. Indeed, some mechanoreceptors can detect even nanometer-scale movements.
Bali, KK, Bégay, V, Estebanez, L, Fleischer, R, Gök, C, Haucke, V, Hoffmann, D, Kuner, R, Kühnemund, J, Lampe, A, Lapatsina, L, Lewin, GR, Moroni, M, Neuenschwander, M, Picci, C, Pifferi, S, Poole, K, Poulet, JFA, Schmoranzer, J, Smith, ESJ, Specker, E, von Kries, JP, Walcher, J, Wetzel, C   +23 more
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Piezo2 is the principal mechanotransduction channel for proprioception [PDF]

Nature Neuroscience, 2015
Proprioception, the perception of body and limb position, is mediated by proprioceptors, specialized mechanosensory neurons that convey information about the stretch and tension experienced by muscles, tendons, skin and joints. In mammals, the molecular identity of the stretch-sensitive channel that mediates proprioception is unknown. We found that the
Seung-Hyun Woo, Viktor Lukacs, Joriene C de Nooij, Dasha Zaytseva, Connor R Criddle, Allain Francisco, Thomas M Jessell, Katherine A Wilkinson, Ardem Patapoutian   +8 more
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3D Microfluidic Bone Tumor Microenvironment Comprised of Hydroxyapatite/Fibrin Composite [PDF]

, 2019
Bone is one of the most common sites of cancer metastasis, as its fertile microenvironment attracts tumor cells. The unique mechanical properties of bone extracellular matrix (ECM), mainly composed of hydroxyapatite (HA) affect a number of cellular ...
Abbasi Aval, Ahn, Ahn, Ahn, Ahn, Alépée, Baek, Bersini, Bielenberg, Camps, Chen, Chung, Coleman, Coste, Dey, Du, Ducy, Friedrich, Gill, Han, Hanawa, Hung, Hytönen, Jacob, Jusoh, Kammori, Karnoub, Katoh, Katt, Kim, Kloss, Lai, LaValley, Li, Li, Lin, Liu, Ma, Mancini, Meena, Mehta, Michor, Mueller-Klieser, Noori, Oh, Pardo-Pastor, Pathi, Pathi, Pietras, Pilmane, Ramaswamy, Rao, Rao, Ribeiro, Rodrigues, Sei, Shamloo, Shi, Sundermeyer, von Tell, Wang, Weis, Yamaguchi, Yin, Yoneda, Yoshikawa, Zhang, Zhu, Zhu   +68 more
core   +2 more sources

Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical Allodynia

Cells, 2022
Mutations in the peroxisomal half-transporter ABCD1 cause X-linked adrenoleukodystrophy, resulting in elevated very long-chain fatty acids (VLCFA), progressive neurodegeneration and an associated pain syndrome that is poorly understood. In the nervous system of mice, we found ABCD1 expression to be highest in dorsal root ganglia (DRG), with satellite ...
Yi Gong, Fiza Laheji, Anna Berenson, April Qian, Sang-O Park, Rene Kok, Martin Selig, Ryan Hahn, Reza Sadjadi, Stephan Kemp, Florian Eichler   +10 more
openaire   +4 more sources

Labeling PIEZO2 activity in the peripheral nervous system

Neuron, 2023
Sensory neurons detect mechanical forces from both the environment and internal organs to regulate physiology. PIEZO2 is a mechanosensory ion channel critical for touch, proprioception, and bladder stretch sensation, yet its broad expression in sensory neurons suggests it has undiscovered physiological roles.
Nicholas W. Villarino, Yasmeen M.F. Hamed, Britya Ghosh, Adrienne E. Dubin, Amanda H. Lewis, Max A. Odem, Meaghan C. Loud, Yu Wang, M. Rocio Servin-Vences, Ardem Patapoutian, Kara L. Marshall   +10 more
openaire   +2 more sources

UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy [PDF]

, 2018
Deafferentation of motor neurons as a result of defective sensory-motor connectivity is a critical early event in the pathogenesis of spinal muscular atrophy, but the underlying molecular pathways remain unknown.
Boyd, Penelope J., Gillingwater, Thomas H., Groen, Ewout J. N., Lamont, Douglas J., Llavero Hurtado, Maica, Schiavo, Giampietro, Shorrock, Hannah K., Sleigh, James N., van der Hoorn, Dinja, Wirth, Brunhilde, Wishart, Thomas M.   +10 more
core   +4 more sources

CaMKII Controls Whether Touch Is Painful [PDF]

, 2015
The sensation of touch is initiated when fast conducting low-threshold mechanoreceptors (Aβ-LTMRs) generate impulses at their terminals in the skin.
Fischer, Gregory, Hogan, Quinn, Hudmon, Andy, Light, Alan R., Meng, Jingwei, Pan, Bin, Rice, Frank L., Stucky, Cheryl, Vilceanu, Daniel, Weyer, Andy, Wu, Hsiang-En, Yu, Hongwei   +11 more
core   +1 more source

The role of the mechanosensitive ion channel Piezo2 in the developing murine heart and brain [PDF]

, 2023
Mechanotransduction, the conversion of mechanical stimuli into electrochemical signals, is a process known to play an essential role in several physiological systems such as somatic sensation and vascular homeostasis.
Pàmpols Pérez, Mireia
core   +1 more source

Mechanosensory Piezo2 regulated by gut microbiota participates in the development of visceral hypersensitivity and intestinal dysmotility

Gut Microbes
The gut microbiota plays a crucial role in the manifestation of intestinal dysfunction associated with irritable bowel syndrome (IBS). The mechanosensory Piezo2 has been implicated in the regulation of intestinal function.
Haonan Zheng, Yuzhu Chen, Siqi Lu, Zuojing Liu, Yinchao Ma, Cunzheng Zhang, Yiming Zhang, Jindong Zhang, Chang Liu, Ming Chu, Fei Pei, Shuangjiang Liu, Liping Duan   +12 more
doaj   +1 more source

Mouse DRG Cell Line with Properties of Nociceptors [PDF]

, 2015
In vitro cell lines from DRG neurons aid drug discovery because they can be used for early stage, high-throughput screens for drugs targeting pain pathways, with minimal dependence on animals.
A Dray, A Montelius, AE Fournier, B Coste, BJ Wainger, C-L Chen, Ciara Doran, D Platika, David Grundy, DC Molliver, F Marmigere, GT Young, I Vetter, J Fjell, J Hjerling-Leffler, J Kim, JJ Cox, JN Wood, Jonathan Chetrit, K Kobayashi, K Kusano, K Shibasaki, MA Nassar, Matthew C. Holley, MD Baker, Mohammed A. Nassar, MS Minett, PS Jat, RW Teichert, S Barnes, S Matsuda, S Ueno, SC Benn, SJ Ravenall, SM Chambers, Theodore John Price, V Neirinckx, W Chen, X Fang, Y Sun   +39 more
core   +2 more sources