Results 61 to 70 of about 5,132 (198)

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys [PDF]

, 2019
Defining cellular and molecular identities within the kidney is necessary to understand its organization and function in health and disease. Here we demonstrate a reproducible method with minimal artifacts for single-nucleus Droplet-based RNA sequencing (
Chen, Song, Gao, Derek, Gaut, Joseph, Hoshi, Masato, Jain, Sanjay, Kim, Eric H., Knoten, Amanda, Lake, Blue B., Plongthongkum, Nongluk, Salamon, Diane, Venkatesh, Ramakrishna, Vijayan, Anitha, Zhang, Kun   +12 more
core   +2 more sources

Expanding the Genotype–Phenotype Correlation of Marden–Walker Syndrome due to PIEZO2 Gene Variants: A Case Report From Brazil

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Marden–Walker syndrome (MWS; OMIM 248700) is an extremely rare congenital disorder characterized by multiple joint contractures, craniofacial dysmorphism, neurological abnormalities, and multisystem involvement. Although historically diagnosed on clinical grounds, only a few cases have been molecularly confirmed.
Guilherme Sotto Battiston, Carolina de Souza Araujo, Fernanda Araujo Romera, André Luis Ferreira, Érica Trovisco Martins, Carolina Galhós de Aguiar, José Eduardo Mourão Santos, Rodrigo Ragazzini, Daniela Testoni Costa‐Nobre, Ana Claudia Yoshikumi Prestes, Allan Chiaratti de Oliveira, Eduardo Perrone, Débora Gusmão Melo, Anne Caroline Barbosa Teixeira, Antonio Victor Campos Coelho, Caio Robledo D’Angioli Costa Quaio, Carolina Araujo Moreno, Eduardo Perrone, Jose Bandeira do Nascimento Junior, Jessica Grasiela Araujo Espolaor, Joana Rosa Marques Prota, Joao Bosco de Oliveira Filho, Jose Ricardo Magliocco Ceroni, Kelin Chen, Letícia Torres Ferreira, Lucas Santos de Santana, Luciana Souto Mofatto, Luiza do Amaral Virmond, Marina de Franca Basto Silva, Michele Patricia Migliavacca, Renata Moldenhauer Minillo, Renata Yoshiko Yamada, Roberta Sitnik, Tatiana Ferreira de Almeida, Thiago Yoshinaga Tonholo Silva, Vivian Pedigone Cintra   +35 more
wiley   +1 more source

An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery. [PDF]

, 2018
Despite major progress in defining the genetic basis of Mendelian disorders, the molecular etiology of many cases remains unknown. Patients with these undiagnosed disorders often have complex presentations and require treatment by multiple health care ...
Bjonnes, Andrew, Briere, Lauren C, Carmichael, Nikkola, Cassa, Christopher A, Chopra, Sameer S, Fay, Christopher J, Feldweg, Anna, Fieg, Elizabeth, Frank, Alexander, Frank, Natasha Y, Goessling, Wolfram, Green, Robert C, Gupta, Vandana A, Haghighi, Alireza, Hanna, Meredith, Klein, Ophir D, Kooshesh, Kameron, Krier, Joel B, Leshchiner, Ignaty, Liao, Eric, Lincoln, Sharyn, Loscalzo, Joseph, Lucia, Stephanie, Maas, Richard L, MacRae, Calum A, Mannstadt, Michael, Mohanty, Anwoy, Nowak, Catherine B, Ouahed, Jodie, Pantazi, Angeliki, Patsopoulos, Nikolaos A, Perroni, Victoria, Perry, Hazel, Qiu, Haiyan, Raychaudhuri, Soumya, Sanchez-Lara, Pedro A, Seidman, Christine E, Snapper, Scott B, Stitziel, Nathan O, Stoler, Joan M, Sunyaev, Shamil R, Sutti, Sheila, Sweetser, David A, Söylemez, Onuralp, Toth-Petroczy, Agnes, Undiagnosed Diseases Network, Brigham and Women’s Hospital FaceBase Project, Brigham Genomic Medicine (BGM), Valerius, Jamie, Vuzman, Dana   +47 more
core  

Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden [PDF]

, 2014
Bladder cancers are a leading cause of death from malignancy. Molecular markers might predict disease progression and behaviour more accurately than the available prognostic factors.
A Roth, AL Gartel, C Balbas-Martinez, C Yau, D Cappellen, D Sidransky, DA Solomon, G Gundem, G Guo, G Lunter, JB Cazier, L Lacombe, LB Alexandrov, ML Lu, MS Lawrence, P Lianes, PJ Goebell, S Denzinger, S Lise, T Abbas, Y Gui, Y Liu   +21 more
core   +3 more sources

PIEZO2 expression is an independent biomarker prognostic for gastric cancer and represents a potential therapeutic target

Scientific Reports
Gastric cancer (GC) is one of the most prevalent malignant tumors of the gastrointestinal system in the globe. The effect of PIEZO2 on the immune function and pathological features of gastric cancer remains to be explored.
Yun-Chao Zhang, Min Yang, Cen-di Lu, Quan-Yao Li, Jin-na Shi, Jun Shi   +5 more
doaj   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source

Stimulation of Piezo1 by mechanical signals promotes bone anabolism [PDF]

, 2019
Mechanical loading, such as caused by exercise, stimulates bone formation by osteoblasts and increases bone strength, but the mechanisms are poorly understood.
Almeida, Maria, Han, Li, Li, Xuehua, Mannen, Erin, Nookaew, Intawat, Silva, Matthew J, Xiong, Jinhu   +6 more
core   +1 more source

Broadband gradient impedance matching using an acoustic metamaterial for ultrasonic transducers [PDF]

, 2017
2016-2017 > Academic research: refereed > Publication in refereed journal201804_a bcmaVersion of ...
Chen, YF, Guo, XS, Li, Z, Liu, SL, Lu, MH, Wang, XL, Wu, HD, Yang, DQ, Yu, SY, Zhang, ST, Zhu, JE, Zhu, MW   +11 more
core   +1 more source

Phosphatidic acid is an endogenous negative regulator of PIEZO2 channels and mechanical sensitivity

Nature Communications
Mechanosensitive PIEZO2 ion channels play roles in touch, proprioception, and inflammatory pain. Currently, there are no small molecule inhibitors that selectively inhibit PIEZO2 over PIEZO1. The TMEM120A protein was shown to inhibit PIEZO2 while leaving
Matthew Gabrielle, Yevgen Yudin, Yujue Wang, Xiaoyang Su, Tibor Rohacs   +4 more
doaj   +1 more source