Results 81 to 90 of about 5,132 (198)

Subtype prediction in pediatric acute myeloid leukemia: Classification using differential network rank conservation revisited [PDF]

, 2015
Background: One of the most important application spectrums of transcriptomic data is cancer phenotype classification. Many characteristics of transcriptomic data, such as redundant features and technical artifacts, make over-fitting commonplace ...
Fornerod, M.W.J. (Maarten), Heuvel-Eibrink, M.M. (Marry) van den, Obulkasim, A. (Askar), Reinhardt, D. (Dirk), Zwaan, C.M. (Michel)   +4 more
core   +1 more source

Mechanobiology in Stem Cell‐Based Bioprinting

Cell Proliferation, EarlyView.
Mechanobiology in stem cell‐based bioprinting is an emerging field that bridges the mechanical conditions of the bioprinting process with the regulation of stem cell behaviour for engineering living tissues. Stresses encountered during bioprinting, together with the mechanical properties of bioinks, play a critical role in regulating stem cell ...
Supeng Ding, Tiankun Liu, Rui Yao
wiley   +1 more source

Gi-Coupled Receptor Activation Potentiates Piezo2 Currents via Gβγ [PDF]

EMBO reports, 2019
SUMMARYDysregulation of mechanosensitive Piezo2 channels is a hallmark of mechanical allodynia, yet the cellular mechanisms that sensitize mechanoreceptors are still poorly understood. Activation of Gi-coupled receptors sensitizes Piezo2 currents, but whether Gi-coupled receptors regulate the activity of Piezo2 channels is not known.
John Smith Del Rosario, Yevgen Yudin, Songxue Su, Cassandra Hartle, Tooraj Mirshahi, Tibor Rohacs   +5 more
openaire   +2 more sources

Prediction of primary somatosensory neuron activity during active tactile exploration [PDF]

, 2016
Primary sensory neurons form the interface between world and brain. Their function is well-understood during passive stimulation but, under natural behaving conditions, sense organs are under active, motor control. In an attempt to predict primary neuron
Abraira, Arabzadeh, Bagdasarian, Bale, Bale, Bale, Bermejo, Birdwell, Clack, Curtis, Diamond, Ebara, Fairhall, Fox, Gibson, Gibson, Hubel, Huber, Jones, Khatri, Kleinfeld, Knutsen, Leiser, Lettvin, Lewen, Lichtenstein, Lottem, Mante, Nelder, O'Connor, O'Connor, Pammer, Paninski, Panzeri, Park, Pearson, Perkon, Peron, Petersen, Petersen, Petreanu, Phillips, Pillow, Poole, Quist, Quist, Rajan, Reinagel, Rice, Simoncelli, Sofroniew, Solomon, Szwed, Szwed, Truccolo, Whiteley, Woo, Yarbus, Yu, Zucker   +59 more
core   +2 more sources

Piezo2 mediates mechanical allodynia in rats with low back pain induced by simulated helicopter low-frequency vibration

陆军军医大学学报
To explore the role and mechanism of mechanically sensitive ion channel Piezo2 in mechanical allodynia of rats with low back pain induced by simulating the low-frequency vibration of a helicopter.
TIAN Yu, LIU Hongzhen, ZHANG Jie
doaj   +1 more source

Mechanical stimulation induces formin-dependent assembly of a perinuclear actin rim [PDF]

, 2015
Proceedings of the National Academy of Sciences of the United States of America11220E2595 ...
Bershadsky, Alexander D, Li, Qingsen, Mogilner, Alex I, Shao, Xiaowei, Shivashankar G.V.   +4 more
core   +1 more source

Cells and ionic conductances contributing to spontaneous activity in bladder and urethral smooth muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Cells and conductances contributing to spontaneous activity in the lower urinary tract. Bladder and urethra exhibit spontaneous contractions at both cellular and tissue levels. Both detrusor and urethral smooth muscle cells display activity that is regular and rhythmic.
Bernard T. Drumm, Neha Gupta, Alexandru Mircea, Caoimhin S. Griffin   +3 more
wiley   +1 more source

Blockade of Piezo2 Pathway Attenuates Inflammatory and Neuropathic Pain in the Orofacial Area

Pain Research and Management
Although previous studies suggest that Piezo2 regulates chronic pain in the orofacial area, few studies have reported the direct evidence of Piezo2’s involvement in inflammatory and neuropathic pain in the orofacial region.
Min-Jeong Jo, Jo-Young Son, Yu-Mi Kim, Jin-Sook Ju, Min-Kyoung Park, Min-Kyung Lee, Dong-Kuk Ahn   +6 more
doaj   +1 more source

Arterial Baroreceptors Sense Blood Pressure through Decorated Aortic Claws

Cell Reports, 2019
Summary: Mechanosensory neurons across physiological systems sense force using diverse terminal morphologies. Arterial baroreceptors are sensory neurons that monitor blood pressure for real-time stabilization of cardiovascular output.
Soohong Min, Rui B. Chang, Sara L. Prescott, Brennan Beeler, Narendra R. Joshi, David E. Strochlic, Stephen D. Liberles   +6 more
doaj   +1 more source

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source