Results 91 to 100 of about 2,249,556 (157)

The role of Piezo1 and Piezo2 proteins in tissue engineering: A Comprehensive review

Engineered Regeneration
Almost every life form, from the tiniest bacterium to humans, is mechanosensitive, implying it can use mechanical stresses to trigger certain physiological responses in the form of electric signals. Mechanotransduction largely relies on ion channels that
Tejaswini Tadge, Ashwini Pattewar, Namdev More, Srivalliputtur Sarath Babu, Ravichandiran Velyutham, Govinda Kapusetti   +5 more
doaj   +1 more source

Piezo2 in bladder-innervating sensory neurons contributes to regulation of contractile activity in cystitis

, 2019
<p>Overactivity of the urinary bladder constitutes one of the main symptoms in various lower urinary tract disorders and it significantly deteriorates quality of life.
Angelika Varga, Klara Matesz, Torres-Perez, Jose, Jose Torres-Perez, La Montanara, Paolo, Joe Chamberlain, Antonio Avelino, Paolo La Montanara, De Sousa Valente, Joao, Botond Gaal, Keller, Esra, Matesz, Klara, Varga, Angelika, Istvan Nagy, Chamberlain, Joe, Nagy, Istvan, Esra Keller, Gaal, Botond, Joao de Sousa Valente, Avelino, Antonio   +19 more
core   +1 more source

Piezo2 is the major transducer of mechanical forces for touch sensation in mice

, 2014
The sense of touch provides critical information about our physical environment by transforming mechanical energy into electrical signals. It is postulated that mechanically activated cation channels initiate touch sensation, but the identity of these ...
Ardem Patapoutian, Wood, John, Valérie Bégay, Allain G. Francisco, Ranade, Sanjeev, Moshourab, R.A., Jayanti Mathur, Wetzel, Christiane, Lewin, G.R., Qiu, Zhaozhu, James Mainquist, Mainquist, J., Bégay, Valérie, Wilson, A.J., A. J. Wilson, Francisco, Allain, Matt Petrus, Gary R. Lewin, Sanjeev S. Ranade, Christiane Wetzel, Patapoutian, A., John N. Wood, Patapoutian, Ardem, Coste, B., Petrus, M., Woo, S.H., Dubin, Adrienne, Dubin, A.E., Petrus, Matt, Rabih A. Moshourab, Mathur, J., Coste, Bertrand, Wetzel, C., Qiu, Z., Mathur, Jayanti, Zhaozhu Qiu, Woo, Seung-Hyun, Seung-Hyun Woo, Reddy, Kritika, Adrienne E. Dubin, Bégay, V., Francisco, A.G., Wilson, A., Wood, J.N., Mainquist, James, Lewin, Gary, Bertrand Coste, Reddy, K., Moshourab, Rabih, Ranade, S.S., Kritika Reddy   +50 more
core   +1 more source

Structural changes during ion channel gating

, 2004
Ion channels are generally multi-subunit complexes, with the ion conduction pathway formed at the subunit interface. In moving between the closed and open states, three structurally distinct channels, represented by the recently determined structures of ...
Doyle, Declan A
core  

Mechanosensitive Ion Channel PIEZO1 Suppresses BMP2‐Induced Ossification of the Annulus Fibrosus Cells

JOR Spine
Objective Major cause of low‐back pain is intervertebral disc degeneration (IVDD), with mechanical stress playing a crucial role in its progression. A mechanosensitive ion channel, PIEZO1, is involved in various musculoskeletal tissues, but its role in ...
Hisakazu Shitozawa, Ryo Nakamichi, Aki Yoshida, Masataka Ueda, Taichi Saito, Koji Uotani, Yoshiaki Oda, Ryo Takatori, Kazutaka Yamashita, Toshifumi Ozaki   +9 more
doaj   +1 more source

Mechanosensitive Piezo channels and their potential roles in peripheral auditory perception

Brain-X
Hearing sound and responding to external and internal mechanical stimuli requires specific proteins as mechanotransducers that convert mechanical forces into biological signals.
Zhangyi Yi, Ge Yin, Chunjiang Wei, Yizhou Quan, Yu Sun   +4 more
doaj   +1 more source

Interaction of fatty acids and phospholipids with multiple binding sites on the potassium channel KcsA

, 2011
The majority of lipids that interact with a transmembrane protein act as a solvent for the protein, forming a shell around it; these lipids are called annular or boundary lipids.
Bolivar Gonzalez, Juan
core   +1 more source

Piezo channels in physical field therapy: From mechanotransduction mechanisms to bioelectromagnetic modulation and biomedical applications. [PDF]

Mechanobiol Med
Li B, Kang HM, Pan WD, Li Y.
europepmc   +1 more source

Exploratory Immunohistochemical Mapping of Mechanosensitivity-Associated Ion Channel Proteins in Terminal Glial Cells of Human Meissner and Pacinian Corpuscles. [PDF]

Int J Mol Sci
Amigo I, García-Mesa Y, Cuendias P, Feito J, García-Suárez O, Abreu-Velez AM, Suazo I, Vega JA.   +7 more
europepmc   +1 more source

Noninvasive biophysical modulations of Piezo ion channels. [PDF]

Microsyst Nanoeng
Pan Y, Chen H, Lee LP.
europepmc   +1 more source