Results 81 to 90 of about 2,249,556 (157)

Single-Molecule Studies of Ion Channels Expressing Unnatural Amino Acids [PDF]

, 2011
The nicotinic acetylcholine receptors are pentameric ligand-gated ion channels that mediate fast synaptic transmission in the brain and peripheral nervous system.
Shanata, Jai Anand Pattur
core   +1 more source

Functional and distinct roles of Piezo2-mediated mechanotransduction in dental primary afferent neurons

International Journal of Oral Science
Piezo2, a mechanosensitive ion channel, serves as a crucial mechanotransducer in dental primary afferent (DPA) neurons and is potentially involved in hypersensitivity to mild mechanical irritations observed in dental patients.
Pa Reum Lee, Kihwan Lee, Ji Min Park, Shinae Kim, Seog Bae Oh   +4 more
doaj   +1 more source

Analysis of Mechanically Activated Ion Channels at the Cell-Substrate Interface: Combining Pillar Arrays and Whole-Cell Patch-Clamp

Frontiers in Bioengineering and Biotechnology, 2019
Ionic currents can be evoked by mechanical inputs applied directly at the cell-substrate interface. These ionic currents are mediated by mechanically activated ion channels, where the open probability increases with increasing mechanical input.
Setareh Sianati, Setareh Sianati, Anie Kurumlian, Anie Kurumlian, Evan Bailey, Kate Poole, Kate Poole   +6 more
doaj   +1 more source

DataSheet2_A pan-cancer analysis reveals the genetic alterations and immunotherapy of Piezo2 in human cancer.PDF

, 2022
Background: Piezo2 is a transmembrane-spanning ion channel protein implicated in multiple physiological processes, including cell proliferation and angiogenesis in many cell types.
Yangpu Jia (13196634), Zhihui Wang (88248), Xin Liu (43569), Zhaoxiong Zhang (11015663), Weihua Fu (553891)   +4 more
core   +1 more source

Table1_A pan-cancer analysis reveals the genetic alterations and immunotherapy of Piezo2 in human cancer.XLSX

, 2022
Background: Piezo2 is a transmembrane-spanning ion channel protein implicated in multiple physiological processes, including cell proliferation and angiogenesis in many cell types.
Yangpu Jia (13196634), Zhihui Wang (88248), Xin Liu (43569), Zhaoxiong Zhang (11015663), Weihua Fu (553891)   +4 more
core   +1 more source

Expression patterns of mechanosensitive ion channel PIEZOs in irreversible pulpitis

BMC Oral Health
Background Mechanosensitive ion channel PIEZOs have been widely reported to involve inflammation and pain. This study aimed to clarify expression patterns of PIEZOs and their potential relations to irreversible pulpitis. Materials and methods Normal pulp
Wenying Yang, Lu Lin, Shucheng Hu, Bin Jiang, Ruhan Yang, Weijun Yu, Jiaqi Tang, Dan Zhao, Yuting Gu, Min Jin, Jin Li, Eryi Lu   +11 more
doaj   +1 more source

Functional and Molecular Characterization of Mechanoinsensitive “Silent” Nociceptors

Cell Reports, 2017
Mechanical and thermal hyperalgesia (pain hypersensitivity) are cardinal signs of inflammation. Although the mechanism underlying thermal hyperalgesia is well understood, the cellular and molecular basis of mechanical hyperalgesia is poorly described ...
Vincenzo Prato, Francisco J. Taberner, James R.F. Hockley, Gerard Callejo, Alice Arcourt, Bassim Tazir, Leonie Hammer, Paulina Schad, Paul A. Heppenstall, Ewan S. Smith, Stefan G. Lechner   +10 more
doaj   +1 more source

Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking

Military Medical Research
Background Tactile and mechanical pain are crucial to our interaction with the environment, yet the underpinning molecular mechanism is still elusive.
Man-Xiu Xie, Ren-Chun Lai, Yi-Bin Xiao, Xi Zhang, Xian-Ying Cao, Xiao-Yu Tian, An-Nan Chen, Zi-Yi Chen, Yan Cao, Xiao Li, Xiao-Long Zhang   +10 more
doaj   +1 more source

Underlying Piezo2 Channelopathy-Induced Neural Switch of COVID-19 Infection

Cells
The focal “hot spot” neuropathologies in COVID-19 infection are revealing footprints of a hidden underlying collapse of a novel ultrafast ultradian Piezo2 signaling system within the nervous system.
Balázs Sonkodi
doaj   +1 more source

Roles of mechanosensitive ion channels in immune cells

Heliyon
Mechanosensitive ion channels are a class of membrane-integrated proteins that convert externalmechanical forces, including stretching, pressure, gravity, and osmotic pressure changes, some of which can be caused by pathogen invasion, into electrical and
Kexin Xia, Xiaolin Chen, Wenyan Wang, Qianwen Liu, Mai Zhao, Jiacheng Ma, Hao Jia   +6 more
doaj   +1 more source