Results 71 to 80 of about 2,249,556 (157)
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.Piezo1 functions as a context‐dependent mechanotransduction node linking mechanical cues to inflammation, tissue remodelling and metabolic regulation in digestive homeostasis and disease. In epithelial, immune, stromal and endocrine cells, Piezo1‐mediated Ca2+ signalling contributes to barrier and mucus homeostasis, epithelial renewal and repair ...
Yuan Xia +6 more
wiley +1 more source
Neurocardiology: Brain–Heart Interactions in the Heart
MedComm, Volume 7, Issue 9, September 2026.The heart and brain maintain systemic homeostasis through bidirectional communication involving neural, biochemical, and mechanical pathways. Dysregulation of these pathways contributes to a spectrum of conditions involving heart–brain interactions, including Takotsubo syndrome, the epileptic heart, stroke–heart syndrome, heart failure, cardiac ...
Wentao Wang +3 more
wiley +1 more source
Piezo2 Expression in Mechanosensitive Dental Primary Afferent Neurons
, 2017 Mechanosensitive ion channels have been suggested to be expressed in dental primary afferent (DPA) neurons to transduce the movement of dentinal fluid since the proposal of hydrodynamic theory.
J. Won +6 more
core +1 more source
Advanced Science, Volume 13, Issue 44, 7 August 2026.This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang +10 more
wiley +1 more source
Piezo2 channels mediate corneal noxious mechanosensation
, 2019 Resumen del póster presentado al 49th Annual Meeting of the Society for Neuroscience, celebrado en Chicago (USA) del 19 al 23 de octubre de 2019.The transduction and encoding of mechanical forces is crucial for many of the most important physiological ...
Gomis, Ana +6 more
core +1 more source
Cutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signalling
Scientific Reports, 2017 We propose a new mechanism of sensory modulation through cutaneous dopaminergic signalling. We hypothesize that dopaminergic signalling contributes to differential cutaneous sensitivity in darker versus lighter pigmented humans and mouse strains. We show
Kentaro Ono +8 more
doaj +1 more source
Comprehensive Physiology, Volume 16, Issue 4, August 2026.Selective purification of heart‐specific spinal and vagal sensory neurons by retrograde labeling and FACS purification showed enhanced spontaneous, optogenetic, and chemically stimulated Ca2+ activity. Transcriptomic profiling identified distinct ion channel and GPCR signatures in heart‐specific sensory neurons.
T. Akgul Caglar +8 more
wiley +1 more source
High conductance anion channel in Schwann cell vesicles from rat spinal roots [PDF]
, 1992 Potassium uptake, possibly together with chloride, is one of the presumed functions of Schwann cells in the peripheral nervous system. However, the presence of chloride channels has not been demonstrated in adult Schwann cells.
Quasthoff, Stefan +5 more
core +1 more source
Mechanosensing Piezo channels in gastrointestinal disorders
The Journal of Clinical Investigation, 2023 All cells in the body are exposed to physical force in the form of tension, compression, gravity, shear stress, or pressure. Cells convert these mechanical cues into intracellular biochemical signals; this process is an inherent property of all cells and
Sandip M. Swain, Rodger A. Liddle
doaj +1 more source
Molecular Mechanisms That Contribute to Bone Marrow Pain
Frontiers in Neurology, 2017 Pain associated a bony pathology puts a significant burden on individuals, society, and the health-care systems worldwide. Pathology that involves the bone marrow activates sensory nerve terminal endings of peripheral bone marrow nociceptors, and is the ...
Jason J. Ivanusic
doaj +1 more source