Results 51 to 60 of about 2,249,556 (157)

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source

Piezo2 mediates mechanical allodynia in rats with low back pain induced by simulated helicopter low-frequency vibration

陆军军医大学学报
To explore the role and mechanism of mechanically sensitive ion channel Piezo2 in mechanical allodynia of rats with low back pain induced by simulating the low-frequency vibration of a helicopter.
TIAN Yu, LIU Hongzhen, ZHANG Jie
doaj   +1 more source

Multiplex epigenome editing of ion channel expression in nociceptive neurons abolished degenerative IVD‐conditioned media‐induced mechanical sensitivity

JOR Spine, 2023
Background Low back pain is a major contributor to disability worldwide and generates a tremendous socioeconomic impact. The degenerative intervertebral disc (IVD) has been hypothesized to contribute to discogenic pain by sensitizing nociceptive neurons ...
Joshua D. Stover, Matthew A. Trone, Brandon Lawrence, Robby D. Bowles   +3 more
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Mechano-Sensing Channel PIEZO2 Enhances Invasive Phenotype in Triple-Negative Breast Cancer [PDF]

, 2022
Background: Mechanically gated PIEZO channels lead to an influx of cations, activation of additional Ca2+ channels, and cell depolarization. This study aimed to investigate PIEZO2’s role in breast cancer.
Arnaldo Mercado-Perez, Eriko Katsuta, Takabe, Kazuaki, Mercado-Perez, Arnaldo, Kazuaki Takabe, Mateusz Opyrchal, Gottlieb, Philip A., Opyrchal, Mateusz, Philip A. Gottlieb, Arthur Beyder, Vujcic, Marija, Katsuta, Eriko, Marija Vujcic, Tao Dai, Beyder, Arthur, Qingfei Wang, Wang, Qingfei, Dai, Tao   +17 more
core   +1 more source

Diversity amongst trigeminal neurons revealed by high throughput single cell sequencing. [PDF]

PLoS ONE, 2017
The trigeminal ganglion contains somatosensory neurons that detect a range of thermal, mechanical and chemical cues and innervate unique sensory compartments in the head and neck including the eyes, nose, mouth, meninges and vibrissae.
Minh Q Nguyen, Youmei Wu, Lauren S Bonilla, Lars J von Buchholtz, Nicholas J P Ryba   +4 more
doaj   +1 more source

A biomechanical optimized Zr58Cu25Al14Nb3 bulk metallic glass dental implant improves peri‐implant stress distribution and bone quality under physiological loading

BMEMat, EarlyView.
This study reports a novel Zr58Cu25Al14Nb3 bulk metallic glass that possesses high mechanical strength and low elastic modulus, which further promotes efficient mechanotransduction and significantly improves peri‐implant bone quality upon cyclic occlusal loading.
Yunshu Wu, Feifei Wang, Yuan He, Yaopeng Zhang, Yuhao Zeng, Fu Zheng, Zhanqi Wei, Sukun Tian, Kinon Chen, Baoan Sun, Yuchun Sun   +10 more
wiley   +1 more source

PIEZO2 in tumors: from mechanobiological switches to activity-targeted therapies

Journal of Experimental & Clinical Cancer Research
Mechanosensitive ion channel PIEZO2 translates microenvironmental forces into Ca²⁺-dependent signals that shape tumor behavior. Across cancers, PIEZO2 exhibits context-dependent roles, with evidence for both pro- and anti-tumor functions, depending on ...
Dan-xia Huang, Qiu-zhi Zhou, Hong-mei Luo, Mohammad Nasb, Yi-zhou Liu, Yu-jie Yang, Hong Chen   +6 more
doaj   +1 more source

Harnessing the nonthermal effects of ultrasound for cancer treatment: From mechanisms to applications

Smart Molecules, EarlyView.
Nonthermal ultrasound transforms acoustic energy into diverse therapeutic bioeffects through cavitation, mechanical stimulation, and physicochemical activation. This review discusses how acoustic parameters, biological mechanisms, and responsive materials interact to influence nonthermal ultrasound‐enabled cancer therapies. Mechanism‐guided engineering
Liu Wang, Huan Tang, Yue Pan, Mingle Li, Weijie Zhao, Kai Liu   +5 more
wiley   +1 more source

Mechanosensitive PIEZO2 channels shape coronary artery development [PDF]

Coronary arteries develop under constant mechanical stress. However, the role of mechanosensitive ion channels in this process remains poorly understood.
Sánchez-Carranza, Oscar, Fürst, C., Pampols-Perez, M., Taube, Martin, Raimundo, Sandra, Lewin, G.R., Sánchez-Carranza, O., Hammes, Annette, Lindberg, E.L., Hammes, A., Hübner, Norbert, Heuser, A., Hübner, N., Taube, M., Fürst, Carina, Lindberg, Eric L., Luo, W., Garcia-Contreras, J.A., Kainmueller, D., Lewin, Gary R., Sporbert, A., Kainmueller, Dagmar, Sporbert, Anje, Cano, E., Pampols-Perez, Mireia, García-Contreras, Jonathan Alexis, Mais, Lisa, Bernabeu, M.O., Heuser, Arnd, Mais, L., Bernabeu, Miguel O.; id_orcid, Gerhardt, H., Luo, Wenhan, Raimundo, S., Cano, Elena, Bernabeu, Miguel O., Gerhardt, Holger   +36 more
core   +1 more source