Results 31 to 40 of about 2,249,556 (157)

Mechanically gated currents in mouse sensory neurons lacking PIEZO2. [PDF]

Biophys J
Touch sensation starts with the opening of mechanically-gated activated ion channels at neuroglial endings of mechanoreceptors in the skin. The function of around half of low threshold mechanoreceptors is dependent on the presence of the mechanically ...
Sánchez-Carranza O, Bégay V, Chakrabarti S, Pampols-Perez M, Wang L, García-Contreras JA, Hammes A, Lewin GR.   +7 more
europepmc   +2 more sources

Mechanically Gated Ion Channels in Mammalian Hair Cells

Frontiers in Cellular Neuroscience, 2018
Hair cells in the inner ear convert mechanical stimuli provided by sound waves and head movements into electrical signal. Several mechanically evoked ionic currents with different properties have been recorded in hair cells.
Xufeng Qiu, Ulrich Müller, Ulrich Müller   +2 more
doaj   +1 more source

Structure, kinetic properties and biological function of mechanosensitive Piezo channels

Cell & Bioscience, 2021
Mechanotransduction couples mechanical stimulation with ion flux, which is critical for normal biological processes involved in neuronal cell development, pain sensation, and red blood cell volume regulation.
Xiang-Zhi Fang, Ting Zhou, Ji-Qian Xu, Ya-Xin Wang, Miao-Miao Sun, Ya-Jun He, Shang-Wen Pan, Wei Xiong, Zhe-Kang Peng, Xue-Hui Gao, You Shang   +10 more
doaj   +1 more source

Miswired Proprioception in Amyotrophic Lateral Sclerosis in Relation to Pain Sensation (and in Delayed Onset Muscle Soreness)—Is Piezo2 Channelopathy a Principal Transcription Activator in Proprioceptive Terminals Besides Being the Potential Primary Damage?

Life, 2023
Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative multisystem disease, with an unknown pathomechanism, resulting in progressive motoneuron loss.
Balázs Sonkodi
doaj   +1 more source

Source Data For: "Focused ultrasound excites action potentials in mammalian peripheral neurons in part through the mechanically gated ion channel Piezo2"

, 2022
Source Data For: "Focused ultrasound excites action potentials in mammalian peripheral neurons in part through the mechanically gated ion channel ...
Lumpkin, Ellen A, Hoffman, Benjamin U
core   +1 more source

Human fetal skin derived merkel cells display distinctive characteristics in vitro and in bio-engineered skin substitutes in vivo

Frontiers in Bioengineering and Biotechnology, 2022
Human skin contains specialized neuroendocrine Merkel cells responsible for fine touch sensation. In the present study, we performed in-depth analysis of Merkel cells in human fetal back skin. We revealed that these Merkel cells expressed cytokeratin 20 (
Katarzyna Michalak-Micka, Katarzyna Michalak-Micka, Dominic Rütsche, Dominic Rütsche, Luca Mazzone, Luca Mazzone, Luca Mazzone, Vanessa L. Büchler, Vanessa L. Büchler, Ueli Moehrlen, Ueli Moehrlen, Ueli Moehrlen, Ueli Moehrlen, Agnes S. Klar, Agnes S. Klar, Thomas Biedermann, Thomas Biedermann, Thomas Biedermann   +17 more
doaj   +1 more source

Charge fluctuations and boundary conditions of biological ion channels : effect on the ionic transition rate [PDF]

, 2009
A self-consistent solution is derived for the Poisson-Nernst-Planck (PNP) equation, valid both inside a biological ion channel and in the adjacent bulk fluid. An iterative procedure is used to match the two solutions together at the channel mouth. Charge
Luchinsky, D. G., McClintock, P. V. E., Eisenberg, R. S., Tindjong, R.   +3 more
core   +4 more sources

In silico Identification of Key Factors Driving the Response of Muscle Sensory Neurons to Noxious Stimuli

Frontiers in Neuroscience, 2021
Nociceptive nerve endings embedded in muscle tissue transduce peripheral noxious stimuli into an electrical signal [i.e., an action potential (AP)] to initiate pain sensations.
Sridevi Nagaraja, Sridevi Nagaraja, Luis F. Queme, Megan C. Hofmann, Shivendra G. Tewari, Shivendra G. Tewari, Michael P. Jankowski, Michael P. Jankowski, Jaques Reifman   +8 more
doaj   +1 more source

Stochastic dynamics of remote knock-on permeation in biological ion channels [PDF]

, 2013
Brownian dynamics simulations provide evidence for a remote knock-on mechanism facilitating the permeation of a biological ion channel by an ion that is initially trapped at the selectivity filter (SF).
P. V. E. McClintock, I. Kaufman, Eisenberg, R. S., Luchinsky, Dmitrii G., D. G. Luchinsky, Kaufman, Igor, Khovanov, I. A., I. A. Khovanov, R. Tindjong, McClintock, P. V. E., Eisenberg, Robert S., McClintock, Peter V. E., R. S. Eisenberg, Tindjong, Rodrigue   +13 more
core   +1 more source

A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels

eLife, 2019
Piezo1 and Piezo2 belong to a family of mechanically-activated ion channels implicated in a wide range of physiological processes. Mechanical stimulation triggers Piezo channels to open, but their characteristic fast inactivation process results in rapid
Wang Zheng, Elena O Gracheva, Sviatoslav N Bagriantsev   +2 more
doaj   +1 more source