Results 11 to 20 of about 2,249,556 (157)

Cell-Type-Specific Splicing of Piezo2 Regulates Mechanotransduction

Cell Reports, 2017
Summary: Piezo2 is a mechanically activated ion channel required for touch discrimination, vibration detection, and proprioception. Here, we discovered that Piezo2 is extensively spliced, producing different Piezo2 isoforms with distinct properties ...
Marcin Szczot, Leah A. Pogorzala, Hans Jürgen Solinski, Lynn Young, Philina Yee, Claire E. Le Pichon, Alexander T. Chesler, Mark A. Hoon   +7 more
doaj   +2 more sources

Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity

Nature Communications, 2020
Mutations in human PIEZO2, encoding for a mechanosensitive ion channel, lead to skeletal abnormalities including scoliosis and hip dysplasia. Here, the authors show that deletion of Piezo2 in proprioceptive neurons, but not in skeletal lineages ...
Eran Assaraf, Ronen Blecher, Lia Heinemann-Yerushalmi, Sharon Krief, Ron Carmel Vinestock, Inbal E. Biton, Vlad Brumfeld, Ron Rotkopf, Erez Avisar, Gabriel Agar, Elazar Zelzer   +10 more
doaj   +2 more sources

Contribution of Piezo2 to Endothelium-Dependent Pain [PDF]

Molecular Pain, 2015
Background We evaluated the role of a mechanically-gated ion channel, Piezo2, in mechanical stimulation-induced enhancement of hyperalgesia produced by the pronociceptive vasoactive mediator endothelin-1, an innocuous mechanical stimulus-induced ...
Luiz F. Ferrari, Oliver Bogen, Paul Green, Jon D. Levine   +3 more
doaj   +2 more sources

Acquired Piezo2 Channelopathy is One Principal Gateway to Pathophysiology

Frontiers in Bioscience-Landmark
The Piezo2 transmembrane proteins were identified by Ardem Patapoutian and his team. They also found that Piezo2 is the principal mechanosensory ion channel responsible for proprioception.
Balázs Sonkodi
doaj   +2 more sources

Self-organized enhancement of conductivity in biological ion channels [PDF]

, 2013
We discuss an example of self-organization in a biological system. It arises from long-range ion–ion interactions, and it leads us to propose a new kind of enhanced conduction in ion channels.
Kaufman, Igor, Khovanov, I. A., Khovanov, Igor A., McClintock, P. V. E., Eisenberg, Robert S., Luchinsky, Dmittri G., McClintock, Peter V. E., Eisenberg, R. S., Luchinsky, Dmitrii G., Tindjong, Rodrigue   +9 more
core   +6 more sources

Non-equilibrium stochastic dynamics of open ion channels [PDF]

, 2013
We present and discuss a modified version of reaction rate theory (RRT) to describe the passage of a positive ion through a biological ion channel. It takes explicit account of the non-equilibrium nature of the permeation process. Unlike traditional RRT,
Kaufman, Igor, Khovanov, Igor A., McClintock, Peter V. E., Eisenberg, R. S., Luchinsky, Dmitrii G., Tindjong, Rodrigue   +5 more
core   +4 more sources

Inactivation Kinetics and Mechanical Gating of Piezo1 Ion Channels Depend on Subdomains within the Cap

Cell Reports, 2020
Summary: Piezo1 ion channels are activated by mechanical stimuli and mediate the sensing of blood flow. Although cryo-electron microscopy (cryo-EM) structures have revealed the overall architecture of Piezo1, the precise domains involved in activation ...
Amanda H. Lewis, Jörg Grandl
doaj   +1 more source

Piezo2 tension sensitivity and its modulation by alternative splicing. [PDF]

Cell Rep
Piezo2 is a force-gated ion channel that functions as a sensor of mechanical touch, proprioception, lung inflation, and gut transit. Human Piezo2 contains seven domains that are alternatively spliced in a tissue-specific fashion resulting in the ...
Sindoni M, Sharp W, Grandl J.
europepmc   +2 more sources

The role of the mechanosensitive ion channel Piezo2 in the developing murine heart and brain [PDF]

, 2023
Mechanotransduction, the conversion of mechanical stimuli into electrochemical signals, is a process known to play an essential role in several physiological systems such as somatic sensation and vascular homeostasis.
Pàmpols Pérez, Mireia
core   +1 more source

Piezo2 expression and its alteration by mechanical forces in mouse mesangial cells and renin-producing cells

Scientific Reports, 2022
The kidney plays a central role in body fluid homeostasis. Cells in the glomeruli and juxtaglomerular apparatus sense mechanical forces and modulate glomerular filtration and renin release.
Yuki Mochida, Koji Ochiai, Takashi Nagase, Keiko Nonomura, Yoshihiro Akimoto, Hiroshi Fukuhara, Tatsuo Sakai, George Matsumura, Yoshihiro Yamaguchi, Miki Nagase   +9 more
doaj   +1 more source