Nature Communications, 2022 A key question in mechanobiology is how mechanical forces are transmitted to PIEZO ion channels. Here, Verkest et al. identify an intracellular channel domain that is required for the activation of PIEZO2 by cytoskeleton-transmitted forces.
Clement Verkest +6 more
doaj +3 more sources
Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels
Cell Reports, 2017 Summary: Several cell types experience repetitive mechanical stimuli, including vein endothelial cells during pulsating blood flow, inner ear hair cells upon sound exposure, and skin cells and their innervating dorsal root ganglion (DRG) neurons when ...
Amanda H. Lewis +3 more
doaj +4 more sources
The Piezo2 ion channel is mechanically activated by low-threshold positive pressure. [PDF]
Sci Rep, 2019 Recent parallel studies clearly indicated that Merkel cells and the mechanosensitive piezo2 ion channel play critical roles in the light-touch somatosensation.
Shin KC +9 more
europepmc +4 more sources
A dual role of PIEZO2 in neuropathic pain: driving peripheral sensitization and enabling mechanical loading-induced analgesia [PDF]
Cell Communication and SignalingBackground Mechanotherapy, a form of mechanical loading (ML), effectively relieves tactile allodynia-associated neuropathic pain by targeting sensitization points stimulated by PIEZO2, a mechanosensitive ion channel.
Chongjie Yao +10 more
doaj +2 more sources
Oligodendrocyte Piezo2 is a regulator of age-dependent myelin integrity and dysregulated in multiple sclerosis [PDF]
Communications BiologyStudies on the mechanosensitive ion channel Piezo2 largely focus on its role in the peripheral nervous system, particularly in touch and pain sensation.
Julia Dyckow-Schubart +12 more
doaj +2 more sources
Piezo channels contribute to the terminal cytodifferentiation of odontoblasts via modulation of canonical Wnt signaling [PDF]
International Journal of Oral SciencePiezo1 and Piezo2 are mechanosensitive ion channels that transduce mechanical stimuli into intracellular biochemical signals in diverse tissues and organ systems. Their functions in odontoblast development are still not well understood. In this study, we
Xuguang Nie +3 more
doaj +2 more sources
A Propeller with a Flexible Twist: A Computational Analysis of Intrinsically Disordered Regions in PIEZO Gating and PIEZO-Associated Channelopathies [PDF]
ProteomesBackground: Mechanosensitive ion channels PIEZO1 and PIEZO2 are key mediators of mechanotransduction, which converts physical forces into cellular signals involved in proprioception, touch, vascular function, and other physiological processes.
Shivam Shukla +3 more
doaj +2 more sources
A pan-cancer analysis reveals the genetic alterations and immunotherapy of Piezo2 in human cancer
Frontiers in Genetics, 2022 Background: Piezo2 is a transmembrane-spanning ion channel protein implicated in multiple physiological processes, including cell proliferation and angiogenesis in many cell types.
Xin Liu +5 more
doaj +1 more source
Frontiers in Physiology, 2021 Piezo2 is a mechanically gated ion-channel that has a well-defined role in innocuous mechanical sensitivity, but recently has also been suggested to play a role in mechanically induced pain.
Sara Nencini +5 more
doaj +1 more source
Piezo2 regulates colonic mechanical sensitivity in a sex specific manner in mice
Nature Communications, 2023 The mechanosensitive ion channel Piezo2 in mucosa and primary afferents transduces colonic mechanical sensation. Here we show that chemogenetic activation or nociceptor-targeted deletion of Piezo2 is sufficient to regulate colonic mechanical sensitivity ...
Jonathan Madar +6 more
doaj +1 more source