Results 21 to 30 of about 2,249,556 (157)
Ion trapping with fast-response ion-selective microelectrodes enhances detection of extracellular ion channel gradients [PDF]
, 2008 Previously, functional mapping of channels has been achieved by measuring the passage of net charge and of specific ions with electrophysiological and intracellular fluorescence imaging techniques.
Collis, Leon P. +3 more
core +1 more source
TMEM150C/Tentonin3 Is a Regulator of Mechano-gated Ion Channels
Cell Reports, 2018 Summary: Neuronal mechano-sensitivity relies on mechano-gated ion channels, but pathways regulating their activity remain poorly understood. TMEM150C was proposed to mediate mechano-activated current in proprioceptive neurons. Here, we studied functional
Evan O. Anderson +4 more
doaj +1 more source
Frontiers in Genetics, 2021 PIEZO2 protein is a unique ion channel that converts mechanical impulses into cellular signals in somatosensory neurons and is involved in various mechanotransduction pathways. The recessive PIEZO2 loss-of-function pathogenic variants are associated with
Magdalena Klaniewska +11 more
doaj +1 more source
Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical Allodynia
Cells, 2022 Mutations in the peroxisomal half-transporter ABCD1 cause X-linked adrenoleukodystrophy, resulting in elevated very long-chain fatty acids (VLCFA), progressive neurodegeneration and an associated pain syndrome that is poorly understood.
Yi Gong +10 more
doaj +1 more source
Cell Reports, 2019 Summary: Touch and mechanical pain represent distinct, but interactive, modalities of mechanosensation. However, the molecular mechanisms underlying these mechanotransduction processes remain incompletely understood.
Mingmin Zhang +4 more
doaj +1 more source
Клинико-генетические характеристики дистальных артрогрипозов, обусловленных мутациями в гене PIEZO2 [PDF]
, 2021 Mutations in the PIEZO2 gene, which is involved in the formation of the mechanosensitive cation channel Piezo2, can cause distal arthrogryposis type 3 (Gordon’s syndrome), type 5, and Marden–Walker syndrome.
А. Ф. Муртазина +11 more
core +1 more source
Frontiers in Cell and Developmental Biology, 2022 The senses of proprioception, touch, hearing, and blood pressure on mechanosensitive ion channels that transduce mechanical stimuli with high sensitivity and speed. This conversion process is usually called mechanotransduction.
Yu-Chia Chuang +3 more
doaj +1 more source
Profile of dorsal root ganglion neurons: study of oxytocin expression
Molecular Brain, 2022 Although dorsal root ganglion (DRG) neurons have been so far classified according to the difference in their fibers (Aβ, Aδ, and C), this classification should be further subdivided according to gene expression patterns.
Taisei Noguri +4 more
doaj +1 more source
TMEM120A/TACAN: A putative regulator of ion channels, mechanosensation, and lipid metabolism
Channels, 2023 TMEM120A (TACAN) is an enigmatic protein with several seemingly unconnected functions. It was proposed to be an ion channel involved in sensing mechanical stimuli, and knockdown/knockout experiments have implicated that TMEM120A may be necessary for ...
Matthew Gabrielle, Tibor Rohacs
doaj +1 more source
Roles of mechanosensitive channel Piezo1/2 proteins in skeleton and other tissues
Bone Research, 2021 Mechanotransduction is a fundamental ability that allows living organisms to receive and respond to physical signals from both the external and internal environments.
Lei Qin +6 more
doaj +1 more source