Results 271 to 280 of about 70,259 (327)

Chromaffin Versus Platelet Granules: What We Have Learned From Chromaffin Cells for Human Studies

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Chromaffin cells and platelets both utilize exocytosis to release biogenic amines stored within large dense‐core vesicles—specifically chromaffin granules (epinephrine) and δ‐granules (serotonin). While the chromaffin cell is the foundational model for studying the secretory pathway, platelets offer a highly accessible human cell source for clinical ...
Ricardo Borges
wiley   +1 more source

Farnesoid x Receptor Deficiency Promotes Hepatocytic Injury in Cyp2c70‐Deficient Mice With a Human‐Like Bile Acid Composition

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Background and Aims Loss‐of‐function mutations in bile acid (BA)‐activated farnesoid x receptor (FXR/NR1H4) cause severe neonatal liver pathology in humans, earlier referred to as progressive familial intrahepatic cholestasis type 5 (PFIC5). However, Fxr‐deficient mice do not develop early‐onset liver disease, possibly due to the predominance ...
Hilde D. de Vries, Jinxiao Li, Kirill Ustyantsev, Milaine V. Hovingh, Niels L. Mulder, Rick Havinga, Anna Palmiotti, Krisztina de Bruyn, Brecht Attema, Ellen Weersing, Rachel E. Thomas, Vincent W. Bloks, Eugene Berezikov, Martijn van Faassen, Henkjan J. Verkade, Jan Freark de Boer, Folkert Kuipers   +16 more
wiley   +1 more source

Haplotype‐Based Analysis of OCA2 Variants in Oculocutaneous Albinism

Pigment Cell &Melanoma Research, Volume 39, Issue 3, May 2026.
This study defines multi‐allele haplotypes, comprised of rare disease variants combined with common eQTL, sQTL and GWAS variants, for oculocutaneous albinism type 2 (OCA2). These haplotypes have implications for variant pathogenicity assessments and phenotypic variability.
Meredith F. Gillis, Madeleine R. Ames, Linnea Lundh, Valer Gotea, Laura Elnitski, Frank Donovan, NISC Comparative Sequencing Program, Adebowale Adeyemo, Charles Rotimi, Brian Brooks, Wadih Zein, William Gahl, William S. Oetting, David R. Adams, Stacie K. Loftus   +14 more
wiley   +1 more source

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Pigment epithelium-derived factor: a potent inhibitor of angiogenesis.

Science, 1999
In the absence of disease, the vasculature of the mammalian eye is quiescent, in part because of the action of angiogenic inhibitors that prevent vessels from invading the cornea and vitreous. Here, an inhibitor responsible for the avascularity of these ocular compartments is identified as pigment epithelium–derived factor (PEDF), a protein previously ...
D. Dawson, O. Volpert, Paul R. Gillis, S. Crawford, Hong‐Ji Xu, W. Benedict, N. Bouck   +6 more
semanticscholar   +3 more sources

Pigment epithelium-derived factor regulation of neuronal and stem cell fate.

Experimental Cell Research, 2020
Pigment epithelium-derived factor (PEDF) is an endogenous human glycoprotein first identified as a neurotrophic factor in retinal pigmented epithelium cells.
Naomi Brook, E. Brook, A. Dharmarajan, A. Chan, C. Dass   +4 more
semanticscholar   +3 more sources

The role of pigment epithelium-derived factor in protecting against cellular stress

Free Radical Research, 2019
Since its discovery as a neurotrophic factor in retinal pigmented epithelium cells in the late 1980s, there has been an increase in understanding of the role that pigment epithelium-derived factor (PEDF) plays in cellular functions.
Naomi Brook, E. Brook, A. Dharmarajan, A. Chan, C. Dass   +4 more
semanticscholar   +3 more sources

Therapeutic Potential of Pigment Epithelium-derived Factor in Cancer.

Current Pharmaceutical Design, 2019
Pigment epithelium-derived factor (PEDF) is one of the serine protease inhibitors with multifunctional properties, which is produced by various types of organs and tissues.
S. Yamagishi, Yoshinori Koga, Ami Sotokawauchi, N. Hashizume, S. Fukahori, T. Matsui, M. Yagi   +6 more
semanticscholar   +3 more sources

Pigment epithelium-derived factor (PEDF) plays anti-inflammatory roles in the pathogenesis of dry eye disease.

The ocular surface, 2021
PURPOSE To investigate the expression of pigment epithelium-derived factor (PEDF) in ocular surface in dry eye disease (DED) and its anti-inflammatory roles and mechanisms, clinically and by experiments in vivo and in vitro.
B. Ma, Yifan Zhou, Rongjun Liu, Kai Zhang, Tingting Yang, Chenxi Hu, Yufei Gao, Q. Lan, Yiyun Liu, X. Yang, H. Qi   +10 more
semanticscholar   +1 more source

Overexpression of Pigment epithelium-derived factor in breast cancer cell-derived exosomes induces M1 polarization in macrophages.

Immunology Letters, 2022
M2 macrophages, the major component of tumor microenvironment, are recognized as important player in tumor progression. M2 macrophages mediate this effect by promoting tumor angiogenesis, tumor metastasis, and suppression of tumor immunity. Reprogramming
Maryam Moradi-Chaleshtori, Ameneh Koochaki, Samaneh Shojaei, M. Paryan, M. Safarzadeh, Seyed Mahmoud Hashemi, Samira Mohammadi-Yeganeh   +6 more
semanticscholar   +1 more source

The increasing role of pigment epithelium-derived factor in metastasis:frombiological importance to a promising target.

Biochemical Pharmacology, 2021
Pigment epithelium-derived factor (PEDF) is a non-inhibitory member of the serpin (serine protease inhibitor) family and is a well-known potent anti-tumor factor in a variety of cancers.
R. Abooshahab, H. Al‐Salami, C. Dass
semanticscholar   +1 more source