Results 291 to 300 of about 70,259 (327)

Focus on Molecules: Pigment epithelium-derived factor (PEDF)

Experimental Eye Research, 2006
1. Structure Pigment epithelium-derived factor (PEDF) is a member of the serpin (serine protease inhibitors) superfamily of proteins related through their highly conserved folded conformation. [Pseudonyms: EPC-1, caspin, SDF3, SERPINF1. PDB: 1IMV. Accession number: human, AAA60058; bovine, AAC48856; mouse, AAC05733; Xenopus tropicalis, AAH62520; dog ...
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Pigment Epithelium-Derived Factor Expression in Colorectal Cancer Patients

Cancer Investigation, 2010
Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis and has been proposed to be a tumor suppressor in a variety of tumors. Limited reports exist of PEDF in colorectal cancer (CRC). We noted a 55% lower plasma level (p < .001) of PEDF in the CRC patient group (1.6 μg/mL) than in of a healthy control group (3.6 μg/mL). A single
Dick, Wågsäter, Sture, Löfgren, Niklas, Zar, Anders, Hugander, Jan, Dimberg   +4 more
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Pigment epithelium‐derived factor inhibits retinal and choroidal neovascularization

Journal of Cellular Physiology, 2001
AbstractIn this study, we investigated whether overexpression of pigment epithelium‐derived factor (PEDF) by gene transfer can inhibit neovascularization by testing its effect in three different models of ocular neovascularization. Intravitreous injection of an adenoviral vector encoding PEDF resulted in expression of PEDF mRNA in the eye measured by ...
K, Mori, E, Duh, P, Gehlbach, A, Ando, K, Takahashi, J, Pearlman, K, Mori, H S, Yang, D J, Zack, D, Ettyreddy, D E, Brough, L L, Wei, P A, Campochiaro   +12 more
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Loss of pigment epithelium‐derived factor leads to ovarian oxidative damage accompanied by diminished ovarian reserve in mice

Life Science, 2019
Aims: This study aims to investigate the pathophysiological role and mechanism of pigment epithelium‐derived factor (PEDF) deletion in ovarian damage. Methods: Female PEDF‐knockout mice and their wild‐type littermates were used in this study.
Xingjian Li, Haiping Wang, Jing Tan, Yandi Wu, Ming Yang, Chengfeng Mao, Sai-fei Gao, Hui Li, Hui Chen, W. Cai   +9 more
semanticscholar   +1 more source

Intracellular pigment epithelium-derived factor contributes to triglyceride degradation

The International Journal of Biochemistry & Cell Biology, 2013
Pigment epithelium-derived factor is well known as a secreted glycoprotein with multiple functions, such as anti-angiogenic, neuroprotective and anti-tumor activities. However, its intracellular role remains unknown. The present study was performed to demonstrate the intracellular function of pigment epithelium-derived factor on triglyceride ...
Zhiyu, Dai, Ti, Zhou, Cen, Li, Weiwei, Qi, Yuling, Mao, Juling, Lu, Yachao, Yao, Lei, Li, Ting, Zhang, Honghai, Hong, Shuai, Li, Weibin, Cai, Zhonghan, Yang, Jianxing, Ma, Xia, Yang, Guoquan, Gao   +15 more
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Role of pigment epithelium-derived factor (PEDF) on arsenic-induced neuronal apoptosis.

Chemosphere, 2019
Chronic exposure to high levels of arsenic is closely associated with nervous system disorders that harm learning, memory, and intelligence. Studies have shown that the primary characteristic of brain damage is neuronal apoptosis.
Wei Zhang, Xiaohui Cui, Yanhui Gao, Liyan Sun, Jing Wang, Yanmei Yang, Xiaona Liu, Yuanyuan Li, Xiangnan Guo, Dianjun Sun   +9 more
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Pigment epithelium‐derived factor is differentially expressed in peripheral neuropathies

PROTEOMICS, 2005
AbstractPeripheral neuropathies are characterized by asymmetrical slowly progressive weakness with no upper motor neuron signs, and can occur either with or without pain. Due to poor knowledge of the disease mechanisms, available pain treatment is very limited.
Conti, Antonio, Ricchiuto, Piero, Iannaccone, Sandro, Sferrazza, Barbara, Cattaneo, Angela, Bachi, Angela, Reggiani, Angelo, Beltramo, Massimiliano, Alessio, Massimo   +8 more
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Pigment epithelium-derived factor peptide reverses mouse age-related meibomian gland atrophy.

Experimental Eye Research, 2019
Age-related meibomian gland (MG) atrophy, characterized by decreased meibocyte proliferation, is one of the causes of meibomian gland dysfunction (MGD), which leads to dry eye disease.
Nai‐Wen Fan, Tsung-Chuan Ho, E. Lin, Cheng-Wen Wu, Hsin-Yu Chien, Y. Tsao   +5 more
semanticscholar   +1 more source

Expression of pigment epithelium-derived factor in human cutaneous appendages

Clinical and Experimental Dermatology, 2013
Pigment epithelium-derived factor (PEDF), a 50-kDa glycoprotein and a member of the serine protease inhibitor gene family, is well known as a potent endogenous inhibitor of angiogenesis. However, the expression of PEDF in human cutaneous appendages has not yet been determined.To investigate the expression of PEDF in human cutaneous appendages ...
C-M, Li, W, Li, X-Y, Man, Z-G, Liu, M, Zheng   +4 more
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Antiangiogenic property of pigment epithelium-derived factor in hepatocellular carcinoma

Hepatology, 2004
Pigment epithelium-derived factor (PEDF) is one of the most powerful endogenous antiangiogenic reagents discovered to date. Its antiangiogenic potential in neoplastic disease remains unclear. In this study, we investigated antiangiogenic property of PEDF in hepatocellular carcinoma (HCC), a typical hypervascular tumor.
Kojiro, Matsumoto, Hiroki, Ishikawa, Daisuke, Nishimura, Keisuke, Hamasaki, Kazuhiko, Nakao, Katsumi, Eguchi   +5 more
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