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Pigment Epithelium-Derived Factor Prevents Melanoma Growth via Angiogenesis Inhibition
Current Pharmaceutical Design, 2008Pigment epithelium-derived factor (PEDF) has recently been shown to be the most potent inhibitor of angiogenesis in the mammalian eye, and is involved in the pathogenesis of angiogenic eye disease such as proliferative diabetic retinopathy. However, a functional role for PEDF in tumor growth and angiogenesis remains to be determined. Melanoma is one of
Riichiro, Abe +3 more
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Protein expression of pigment-epithelium-derived factor in rat cochlea
Cell and Tissue Research, 2008Pigment-epithelium-derived factor (PEDF) is a 50-kDa glycoprotein with well-recognised expression in various mammalian organs showing diverse (e.g. anti-angiogenic and neuroprotective) activities. However, at present, no information is available regarding the potential function of this cytokine in the inner ear.
Otto, Gleich, Ana Luisa, Piña
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Localization of Pigment Epithelium-Derived Factor in Growing Mouse Bone
Calcified Tissue International, 2004Pigment epithelium-derived factor (PEDF) is a potent anti-angiogenic factor found in a wide range of fetal and adult tissues, where it is thought to play a role in the regulation of angiogenesis during development. The temporal expression of PEDF during endochondral bone formation has not previously been reported.
Gerald M Y, Quan +5 more
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Effects of pigment epithelium-derived factor on traumatic brain injury
Restorative Neurology and Neuroscience, 2015Purpose: Pigment epithelium-derived factor (PEDF) is a multifunctional protein with antiangiogenic, anti-inflammatory, neurotrophic and neurogenic properties. The effect of PEDF on traumatic brain injury (TBI) has not been explored. In this study, we aimed to show the in vivo effects of PEDF on lesion volume, cell death and cell proliferation after ...
Menderes Yusuf, Terzi +9 more
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Pigment epithelium–derived factor exerts antioxidative effects in granulosa cells
Fertility and Sterility, 2014To determine whether supplementing granulosa cells cultures with pigment epithelium-derived factor (PEDF) can protect them from oxidative stress.We used either granulosa cell line or human primary granulosa cell culture from women undergoing in vitro fertilization (IVF) treatments.University research facilities.Imprinting control region female mice ...
Hadas, Bar-Joseph +4 more
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Pigment Epithelium-Derived Factor (PEDF) in the Retina
2007Pigment epithelium-derived factor (PEDF) was first described as a secreted product of human fetal retinal pigment epithelial (RPE) cells in culture with a potent neuronal differentiating activity on human retinoblastoma Y-79 cells.1 It was reported that PEDF at nanomolar concentrations induces a morphological differentiation of Y-79 cells ...
S. Patricia Becerra +5 more
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Pigment epithelium-derived factor expression and role in follicular development
Reproductive BioMedicine OnlineWhat is the involvement of pigment epithelium-derived factor (PEDF), expressed in granulosa cells, in folliculogenesis?mRNA expression of PEDF and other key factors [Cyp19, anti-Müllerian hormone receptor (AMHR) and vascular endothelial growth factor (VEGF)] in mice follicles was examined in order to typify the expression of PEDF in growing follicles ...
Rana Tarabeih +6 more
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