Results 281 to 290 of about 70,259 (327)

The biological relevance of pigment epithelium-derived factor on the path from aging to age-related disease.

Mechanisms of Ageing and Development, 2021
Pigment epithelium-derived factor (PEDF) is an endogenously produced protein that contributes to cell growth arrest, and reduced levels of PEDF are associated with the progression of cellular senescence and the aging process.
R. Abooshahab, C. Dass
semanticscholar   +1 more source

Pigment epithelium-derived factor alleviates depressive-like behaviors in mice by modulating adult hippocampal synaptic growth and Wnt pathway.

Progress in Neuro-psychopharmacology and Biological Psychiatry, 2020
Pigment epithelium-derived factor (PEDF, also known as SERPINF1) is a secreted glycoprotein with neuroprotective effects. However, the potential role of PEDF in major depressive disorder (MDD) remains largely unknown.
Tian Tian, Yongtao Yang, Bing Xu, Yinhua Qin, G. Zang, Chanjuan Zhou, Peng Zheng, Jin Chen, Ke Cheng, Jianjun Chen, Xue Gong, P. Xie   +11 more
semanticscholar   +1 more source

Pigment Epithelium-derived Factor (PEDF) and Cardiometabolic Disorders

Current Pharmaceutical Design, 2014
The metabolic syndrome is strongly associated with insulin resistance and visceral obesity and consists of a constellation of factors such as diabetes, hypertension, dyslipidemia and non-alcoholic steatohepatits, which could in concert increase the risk for cardiovascular diseases (CVD).
Sho-Ichi, Yamagishi, Takanori, Matsui
openaire   +2 more sources

Plasma rich in growth factors reduces blue light-induced oxidative damage on retinal pigment epithelial cells and restores their homeostasis by modulating vascular endothelial growth factor and pigment epithelium-derived factor expression.

Clinical and Experimental Ophthalmology, 2020
BACKGROUND To analyze the effectiveness of plasma rich in growth factors (PRGF) in reducing the oxidative stress induced by blue-light exposition on retinal pigment epithelial cells.
E. Anitua, M. de la Fuente, S. del Olmo-Aguado, C. Suárez-Barrio, J. Merayo-Lloves, F. Muruzábal   +5 more
semanticscholar   +1 more source

Pigment epithelium‐derived factor (PEDF) is an endogenous antiinflammatory factor

The FASEB Journal, 2005
ABSTRACT Pigment epithelium‐derived factor (PEDF) is a potent angiogenic inhibitor. Reduced PEDF levels are associated with diabetic retinopathy. However, the mechanism for the protective effects of PEDF against diabetic retinopathy (DR) is presently unclear.
Sarah X, Zhang, Joshua J, Wang, Guoquan, Gao, Chunkui, Shao, Robert, Mott, Jian-xing, Ma   +5 more
openaire   +2 more sources

Upregulation of pigment epithelium-derived factor after laser photocoagulation

American Journal of Ophthalmology, 2001
To determine the changes in the expression of pigment epithelium-derived factor in cultured human retinal pigment epithelial cells and rat retinas after laser photocoagulation.Experimental study of laser photocoagulation on human retinal pigment epithelial cells in culture and on adult rats.
N, Ogata, J, Tombran-Tink, N, Jo, D, Mrazek, M, Matsumura   +4 more
openaire   +2 more sources

Pigment epithelium‐derived factor negates oxidative stress in mouse oocytes

The FASEB Journal, 2021
Abstract Molecular changes, caused by various environmental factors, affect the quality and developmental potential of oocytes. Oxidative stress (OS) is a major factor involved in various gynecologic disorders and/or in aging. Recent studies suggest that elevated reactive oxygen species (ROS) hamper oocyte quality and future embryonic
Luba Nemerovsky, Hadas Bar‐Joseph, Anat Eldar‐Boock, Irit Miller, Ido Ben‐Ami, Ruth Shalgi   +5 more
openaire   +2 more sources

Pigment Epithelium-Derived Factor and Angiogenesis

2008
Pigment epithelium-derived factor (PEDF), an extracelullar glycoprotein of 50 kDa, is one of the main anti-angiogenic factors of the eye. Its main source is the retinal pigment epithelium, from which the mature protein is secreted in a polarized fashion toward the retina.
Juan Amaral, S. Patricia Becerra
openaire   +1 more source

Pigment Epithelium-Derived Factor

Exercise and Sport Sciences Reviews, 2011
Pigment epithelium-derived factor (PEDF), an adipokine, is a regulator of oxidative stress, inflammation, angiogenesis, and insulin sensitivity. Contrary to animal and cell culture data, inhibition of the sympathoadrenal system does not affect serum PEDF in humans.
openaire   +2 more sources

Production of active pigment epithelium-derived factor inE. coli

Biotechnology Letters, 2005
Human pigment epithelium-derived factor (PEDF), a neurotrophic factor, is the most potent natural inhibitor of angiogenesis. To produce the active PEDF, the gene coding for the human PEDF protein was expressed in E. coli. The rPEDF protein was expressed at 457 mg l-1 as a soluble protein. The yield of purified GST fusion protein was 14 mg l-1. Purified
Tao, Zhang, Ming, Guan, Yuan, Lu
openaire   +2 more sources