Cardiovascular Innovations and Applications, 2023 Objective: This study describes the expression profiles and roles of cardiac pigment epithelium-derived factor (PEDF) during cardiac development.
Xing-hui Li +12 more
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Photo-damage, photo-protection and age-related macular degeneration [PDF]
, 2015 Age-related macular degeneration (AMD) is a degenerative retinal disease that causes blindness in people 60-65 years and older, with the highest prevalence appearing in people 90 years-old or more.
Marquioni Ramella, Melisa Daniela +1 more
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Pigment Epithelium-Derived Factor: Chemistry, Structure, Biology, and Applications [PDF]
Journal of Biomedicine and Biotechnology, 2012 Pigment epithelium-derived factor (PEDF) is a multifunctional serpin protein with demonstrable neurotrophic, antiangiogenic, antitumorigenic, antimetastatic, anti-inflammatory, antioxidative properties among others. PEDF exists naturally in most organs of the human body, and it is released from most cell types as an extracellular diffusible and ...
Becerra, S.P. +3 more
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Advances in mechanism on pigment epithelium derived factor in diabetes retinopathy [PDF]
Zhenduanxue lilun yu shijianDiabetic retinopathy (DR) is one of the most common microvascular complications of diabetes mellitus.The incidence of DR （1980-2018: 2.2%-12.7%） increases year by year. The incidence of DR in China is 18.45%, and global prevalence is 22.27%.
ZHOU Sifeng, ZHU Jieyun, XU Haishu, NI Ying
doaj +1 more source
Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids [PDF]
, 2019 Tissue specific extracellular matrices (ECM) provide structural support and enable access to molecular signals and metabolites, which are essential for directing stem cell renewal and differentiation.
Al-Aama, Jumana +15 more
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Pigment epithelium-derived factor as a multifunctional antitumor factor
Journal of Molecular Medicine, 2006 The design of new therapeutic strategies for cancer treatment is based on the combination of drugs directed against different tumor compartments, including the tumor cells themselves and components of the stroma, such as the tumor vasculature. Indeed, several antiangiogenic compounds have entered clinical trials for use alone or in combination with ...
Fernández-García, Nuria Isabel +2 more
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Türk Biyokimya Dergisi, 2023 Diabetic retinopathy (DRP) is one of the most common microvascular complications of diabetes. The pigment epithelium-derived factor (PEDF) is a protein that is one of the most potent angiogenesis inhibitors.
Şahin Tayfun, Karabulut Alpaslan
doaj +1 more source
Pigment epithelium-derived factor and matrix metalloproteinase-9 in liver cirrhosis
The Saudi Journal of Gastroenterology, 2016 Background/Aim: The aim of this study was to assess the role of serum pigment epithelium-derived factor (PEDF) and matrix metalloproteinase-9 (MMP-9) in progression of liver cirrhosis and development of hepatocellular carcinoma (HCC).
Joanna Kozlowska +6 more
doaj +1 more source
Potential therapeutic effects of pigment epithelium-derived factor for treatment of diabetic retinopathy [PDF]
International Journal of Ophthalmology, 2013 Diabetic retinopathy (DR), a major micro-vascular complication of diabetes, has emerged as a leading cause of visual impairment and blindness among working adults in the worldwide.
Xiao Liu, Hui-Hui Chen, Li-Wei Zhang
doaj +1 more source
The ratio of VEGF/PEDF expression in bone marrow mesenchymal stem cells regulates neovascularization [PDF]
, 2011 Angiogenesis, or neovascularization, is a finely balanced process controlled by pro- and anti-angiogenic factors. Vascular endothelial growth factor (VEGF) is a major pro-angiogenic factor, whereas pigment epithelial-derived factor (PEDF) is the most ...
Crawford, Ross, Fan, Wei, Xiao, Yin
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