Pigment epithelium-derived factor (PEDF) negates hyperandrogenic PCOS features [PDF]
Journal of Endocrinology, 2020 Polycystic ovary syndrome (PCOS), one of the most common female endocrine disorder, is a prevalent cause of infertility. Hyperandrogenism is a key feature in PCOS and is correlated with increased expression of VEGF and cytokines in the ovaries. We have previously shown that pigment epithelium-derived factor (PEDF), an endogenous protein, presents ...
Irit, Miller +4 more
openaire +2 more sources
Autophagy: a new mechanism for regulating VEGF and PEDF expression in retinal pigment epithelium cells [PDF]
International Journal of Ophthalmology, 2019 AIM: To investigate the regulation of vascular endothelial growth factors (VEGF) and pigment epithelium-derived factor (PEDF) expression by autophagy in retinal pigment epithelium (RPE) cells on exposure to hypoxia.
Rong Li +4 more
doaj +1 more source
Pigment epithelium-derived factor: a multimodal tumor inhibitor [PDF]
Molecular Cancer Therapeutics, 2006 Abstract Pigment epithelium-derived factor (PEDF), a noninhibitory member of the serine protease inhibitor (serpin) family, is a well-known potent endogenous inhibitor of angiogenesis. It has been known for years to be aberrantly expressed in ocular disorders, but in recent years, down-regulation has been shown to be prevalent in a range
Ek, Eugene T. H +2 more
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Preliminary study on electrophysiological changes after cellular autograft in age-related macular degeneration [PDF]
, 2014 Background: Evolving atrophic macular degeneration represents at least 80% of all macular degenerations and is currently without a standardized care. Autologous fat transplantation (AFT) efficacy was demonstrated by several studies, since these cells are
C., Limoli +4 more
core +1 more source
Downregulation of pigment epithelium-derived factor in condyloma acuminatum [PDF]
Journal of International Medical Research, 2013 Objectives To investigate pigment epithelium-derived factor (PEDF) mRNA and protein levels in condyloma acuminatum, and their relationship with angiogenesis and keratinocyte proliferation. Methods Lesions from male patients with condyloma acuminatum and skin from healthy male (control) subjects were collected.
Yu-hao, Dong +5 more
openaire +2 more sources
The ocular surface, 2020 PURPOSE In this study, we quantify Pigment Epithelium-derived Factor (PEDF) secreted by corneal epithelial cells and its immunomodulatory functions in a murine model of dry eye disease (DED).
R. Singh +6 more
semanticscholar +1 more source
Nel positively regulates the genesis of retinal ganglion cells by promoting their differentiation and survival during development [PDF]
, 2014 Peer reviewedPublisher ...
Adams JC +67 more
core +1 more source
Retinal pigment epithelium degeneration caused by aggregation of PRPF31 and the role of HSP70 family of proteins [PDF]
, 2020 Background Mutations in pre-mRNA splicing factor PRPF31 can lead to retinitis pigmentosa (RP). Although the exact disease mechanism remains unknown, it has been hypothesized that haploinsufficiency might be involved in the ...
Aramburu, Ana +13 more
core +2 more sources
Profound Re-Organization of Cell Surface Proteome in Equine Retinal Pigment Epithelial Cells in Response to In Vitro Culturing [PDF]
, 2012 The purpose of this study was to characterize the cell surface proteome of native compared to cultured equine retinal pigment epithelium (RPE) cells. The RPE plays an essential role in visual function and represents the outer blood-retinal barrier.
Aisenbrey +54 more
core +3 more sources
Molecular Therapy: Methods & Clinical Development, 2019 Age-related macular degeneration (AMD) is a progressive retinal disorder characterized by imbalanced pro- and antiangiogenic signals. The aim of this study was to evaluate the effect of ex vivo cell-based gene therapy with stable expression of human ...
Maria Hernandez +18 more
doaj +1 more source