Ablation of pigment epithelium-derived factor receptor (PEDF-R/Pnpla2) causes photoreceptor degeneration [PDF]
Journal of Lipid Research, 2023 Photoreceptor cells express the patatin-like phospholipase domain-containing 2 (PNPLA2) gene that codes for pigment epithelium-derived factor receptor (PEDF-R) (also known as ATGL).
Alexandra Bernardo-Colón +5 more
doaj +2 more sources
Pigment epithelium-derived factor is an interleukin-6 antagonist in the RPE: Insight of structure-function relationships [PDF]
Frontiers in Physiology, 2022 Retinal and choroidal inflammatory lesions increase the levels of the pro-inflammatory cytokine interleukin-6 (IL-6). Pigment epithelium-derived factor (PEDF) has anti-inflammatory properties, but it is not known if it can prevent the production of IL-6 ...
Alexandra Bernardo-Colón +2 more
doaj +2 more sources
Pigment Epithelium-Derived Factor (PEDF) Receptors Are Involved in Survival of Retinal Neurons. [PDF]
Int J Mol Sci, 2020 The demise of retinal ganglion cells (RGCs) is characteristic of diseases of the retina such as glaucoma and diabetic or ischemic retinopathies. Pigment epithelium-derived factor (PEDF) is a multifunctional secreted protein that mediates neuroprotection ...
Bürger S +7 more
europepmc +2 more sources
Pigment Epithelium-Derived Factor as a Possible Treatment Agent for Choroidal Neovascularization. [PDF]
Oxid Med Cell Longev, 2020 Choroidal neovascularization (CNV) is a sight-threatening disease and is characterized by the formation of pathological neovascularization in the choroid which extends into the subretinal space.
Xi L.
europepmc +2 more sources
Degradation of Photoreceptor Outer Segments by the Retinal Pigment Epithelium Requires Pigment Epithelium-Derived Factor Receptor (PEDF-R). [PDF]
Invest Ophthalmol Vis Sci, 2021 Purpose To examine the contribution of PEDF-R to the phagocytosis process. Previously, we identified PEDF-R, the protein encoded by the PNPLA2 gene, as a phospholipase A2 in the retinal pigment epithelium (RPE).
Bullock J +6 more
europepmc +2 more sources
Serum Pigment Epithelium-Derived Factor Levels are Associated with Estradiol and Decrease After Adjusting for Alanine Aminotransferase in Chinese Women Based on Multiple Linear Regression Analysis [PDF]
Diabetes, Metabolic Syndrome and Obesity, 2022 Cuiliu Li, Yunna Zhang, Fang Gao The Second Department of Endocrinology, Cangzhou Central Hospital, Cangzhou, 061001, People’s Republic of ChinaCorrespondence: Cuiliu Li, Tel +8603172075935, Email licuiliu1989@163.comPurpose: To assess changes in pigment
Li C, Zhang Y, Gao F
doaj +2 more sources
Pigment Epithelium-Derived Factor-Loaded PEGylated Nanoparticles as a New Antiangiogenic Therapy for Neovascularization [PDF]
Journal of Diabetes Research, 2022 Background. Pathological neovascularization, which involves a disruption in the balance between angiogenic and antiangiogenic factors under pathological conditions, is the basis of many intraocular diseases.
Feng Zhao +4 more
doaj +2 more sources
Pigment epithelium-derived factor in the monkey retinal pigment epithelium and interphotoreceptor matrix: apical secretion and distribution [PDF]
Experimental Eye Research, 2004 Pigment epithelium-derived factor (PEDF) is an extracellular protein derived from the retinal pigment epithelium (RPE), a tissue formed by polarized cells that release growth and trophic factors in a directional fashion.
Becerra, S.P. (S.P.) +5 more
core +3 more sources
Lipids in Health and Disease, 2018 Cardiovascular disease (CVD) is a leading cause of death worldwide. Atherosclerosis is believed to be the major cause of CVD, characterized by atherosclerotic lesion formation and plaque disruption.
Shouyuan Ma +4 more
doaj +2 more sources
Association of pigment epithelium derived factor expression with cancer progression and prognosis: a meta-analysis study [PDF]
Discover Oncology, 2021 Background Pigment epithelium derived factor (PEDF) is a secreted protein that strongly suppresses angiogenesis and directly inhibits cancer cells proliferation.
Guo Cheng, Crystal Song
doaj +2 more sources