Pigment epithelium-derived factor promotes peritoneal dissemination of ovarian cancer through induction of immunosuppressive macrophages [PDF]
Communications Biology, 2022 Endogenously expressed pigment epithelium–derived factor (PEDF) promotes increased survival of ovarian cancer cells in the peritoneal cavity by inducing IL-10 expression in CD206 + peritoneal macrophages.
Sayaka Ueno +3 more
doaj +3 more sources
Anti-inflammatory properties of pigment epithelium-derived factor
European Journal of Inflammation, 2022 Inflammation is part of the complex biological response to harmful stimuli, such as cell damage, pathogens, or irritants. An excessive inflammatory response can lead to a variety of diseases.
Ting He, Wei Liu, Chuan-an Shen
doaj +3 more sources
Pigment epithelium-derived factor in lipid metabolic disorders
Biomedical Journal, 2018 Pigment epithelium-derived factor (PEDF) is a secreted glycoprotein that has anti-angiogenic, anti-proliferative, neurotrophic and immunomodulatory properties.
Kuang-Tzu Huang +4 more
doaj +4 more sources
Pigment Epithelium-Derived Factor and Sex Hormone-Responsive Cancers. [PDF]
Cancers (Basel), 2020 Simple Summary The ongoing clinical need to improve cancer therapies warrants a better understanding of the mechanisms behind cancer growth and its spread to distant organs.
Brook N +4 more
europepmc +5 more sources
Potential application value of pigment epithelium-derived factor in sensorineural hearing loss [PDF]
Frontiers in Neuroscience, 2023 The inner ear is a complex and precise auditory perception system responsible for receiving and converting sound signals into neural signals, enabling us to perceive and understand sound.
Zihui Sun +12 more
doaj +2 more sources
Triglyceride-glucose index is prospectively associated with chronic kidney disease progression in Type 2 diabetes - mediation by pigment epithelium-derived factor. [PDF]
Diab Vasc Dis Res, 2022 Background Triglyceride-glucose (TyG) index is a surrogate marker of insulin resistance. Its role in chronic kidney disease (CKD) progression in Type 2 Diabetes Mellitus (T2DM) is unclear.
Low S +10 more
europepmc +2 more sources
Pigment epithelium-derived factor protects retinal ganglion cells [PDF]
BMC Neuroscience, 2007 Background Retinal ganglion cells (RGCs) are responsible for the transmission of visual signals to the brain. Progressive death of RGCs occurs in glaucoma and several other retinal diseases, which can lead to visual impairment and blindness.
Fleenor Debra L +3 more
doaj +3 more sources
Pigment Epithelium-Derived Factor Enhances the Suppressive Phenotype of Regulatory T Cells in a Murine Model of Dry Eye Disease. [PDF]
Am J Pathol, 2021 Pigment Epithelium-derived Factor (PEDF) is a widely expressed 50kD glycoprotein belonging to the serine protease inhibitor family with well-established anti-inflammatory functions.
Singh RB +6 more
europepmc +2 more sources
Pigment Epithelium-Derived Factor Peptide Promotes Corneal Nerve Regeneration: An In Vivo and In Vitro Study. [PDF]
Invest Ophthalmol Vis Sci, 2021 Purpose To investigate the potential of a pigment epithelium-derived factor (PEDF) peptide 44-mer to promote nerve regeneration in a rabbit corneal nerve injury model to demonstrate its neurotrophic ability in cultivated mouse trigeminal neuron cells ...
Yeh SI +6 more
europepmc +2 more sources
Pigment epithelium-derived factor (PEDF) and derived peptides promote survival and differentiation of photoreceptors and induce neurite-outgrowth in amacrine neurons. [PDF]
J Neurochem, 2021 Pigment epithelium‐derived factor (PEDF) is a cytoprotective protein for the retina. We hypothesize that this protein acts on neuronal survival and differentiation of photoreceptor cells in culture.
Michelis G +6 more
europepmc +2 more sources