Results 21 to 30 of about 70,259 (327)
Disease Models & Mechanisms, 2019 Dysfunction and loss of the retinal pigment epithelium (RPE) are hallmarks of retinal degeneration, but the underlying pathogenetic processes are only partially understood.
Yu Chen +8 more
doaj +2 more sources
A role of pigment epithelium-derived factor in zinc-mediated mechanism of neurodegeneration in glaucoma [PDF]
Communications BiologyGlaucoma is a neurodegenerative condition involving optic nerve damage and retinal ganglion cells death. Animal studies suggested that the pathway linking these events can be mediated by mobile zinc secreted into the intraretinal space and exerting ...
Dmitry V. Chistyakov +36 more
doaj +2 more sources
Pigment epithelium derived factor drives melanocyte proliferation and migration in neurofibromatosis café au lait macules [PDF]
Skin Health and DiseaseBackground RASopathies, which include neurofibromatosis type 1 (NF1), are defined by Ras/mitogen‐activated protein kinase (Ras/MAPK) pathway activation.
Charlotte Lovatt +18 more
doaj +2 more sources
Pigment Epithelium-Derived Factor Affects Angiogenesis in Celiac Disease. [PDF]
Med Princ Pract, 2019 <b><i>Objective:</i></b> Recent studies have demonstrated that angiogenesis is impaired in patients with celiac disease (CD). In this study, we evaluated the levels of the novel antiangiogenic factor pigment epithelium-derived factor (PEDF) in CD patients.
Akpinar MY +5 more
europepmc +5 more sources
Pigment Epithelium-Derived Factor Contributes to Insulin Resistance in Obesity [PDF]
Cell Metabolism, 2009 Obesity is a major risk factor for insulin resistance; however, the factors linking these disorders are not well defined. Herein, we show that the noninhibitory serine protease inhibitor, pigment epithelium-derived factor (PEDF), plays a causal role in insulin resistance.
Crowe, Seamus +9 more
openaire +4 more sources
Protective effects of pigment epithelium-derived factor against X-ray-induced retinopathy
Fushe yanjiu yu fushe gongyi xuebao, 2022 The protective effects of pigment epithelium-derived factor (PEDF) against X-ray-induced retinopathy were investigated in vitro and in vivo. The function of PEDF was suppressed using PEDF receptor inhibitors and transfection of siRNA in human retinal ...
ZHU Ran +6 more
doaj +1 more source
Pigment epithelium-derived factor and its role in microvascular-related diseases.
Biochimie, 2022 Microvascular diseases are among the most clinically important diseases, and vascular abnormalities are central in the development of such diseases.
Yuzhuo Wang +9 more
semanticscholar +1 more source
Secretion of pigment epithelium‐derived factor [PDF]
European Journal of Biochemistry, 2003 Pigment epithelium‐derived factor (PEDF), a neurotrophic and antiangiogenic protein, is an extracellular component of the retinal interphotoreceptor matrix which has been shown to be secreted by human fetal retinal pigment epithelial cells. It belongs to the serpin superfamily and contains the typical exposed reactive center loop.
Hanshuang, Shao +2 more
openaire +2 more sources
Pigment Epithelium-Derived Factor Decreases Outflow Facility [PDF]
Investigative Opthalmology & Visual Science, 2013 Pigment epithelium-derived factor (PEDF) regulates blood-retinal barrier function. As a constituent of aqueous humor, the role of PEDF in conventional outflow function is unknown. The goals of the study were to examine the effects of PEDF on barrier function of cultured Schlemm's canal (SC) endothelia and outflow facility in mouse eyes in situ.To model
Morgan E, Rogers +6 more
openaire +2 more sources