Results 31 to 40 of about 35,403 (233)

Genetic deciphering of the antagonistic activities of the melanin-concentrating hormone and melanocortin pathways in skin pigmentation.

PLoS Genetics, 2020
The genetic origin of human skin pigmentation remains an open question in biology. Several skin disorders and diseases originate from mutations in conserved pigmentation genes, including albinism, vitiligo, and melanoma.
Romain Madelaine, Keri J Ngo, Gemini Skariah, Philippe Mourrain   +3 more
doaj   +1 more source

Phototherapy as an effective treatment for Majocchi's disease - Case report [PDF]

Anais Brasileiros de Dermatologia, 2015
Pigmented purpuric dermatoses are chronic and relapsing disorders characterized by a symmetrical rash of petechial and pigmentary macules, mainly confined to the lower limbs. Purpura annularis telangiectodes of Majocchi is a
Tapan Kumar Dhali, Monica Chahar, Mohammad Asad Haroon   +2 more
doaj   +1 more source

Hypomelanosis of Ito–Brain Melanin Deposition on Magnetic Resonance Imaging: A Preliminary Hypothesis Based on Two Pediatric Cases [PDF]

Annals of Child Neurology
To investigate brain melanin deposition on magnetic resonance imaging (MRI) in hypomelanosis of Ito (HI) by presenting two clinical cases and reviewing relevant literature.
Roshwanth Arbujin, Sameer Peer, Balachandar Vellingiri, Madhu S. Gaddigoudar, Pawan Kumar Ghanghoriya, Arvinder Wander   +5 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Biology of melanocytes in mammals

Frontiers in Cell and Developmental Biology, 2023
Melanocytes, which originate from the neuroectoderm, are specialized cells responsible for producing pigments and possessing a dendritic morphology. These cells migrate to the epidermis and follicles, contributing to skin and hair pigmentation during ...
Ying-Zhe Cui, Xiao-Yong Man
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Dabigatran‐induced esophagitis with full circumferential blue pigmentation

DEN Open
Dabigatran is a useful and widely used drug for stroke prevention in patients with atrial fibrillation. However, it has been reported to cause esophagitis.
Tomonori Araki, Kohei Hayashi, Yuki Sonoda, Takuya Honda, Yoshifumi Imamura, Yuji Koide, Hisayuki Hamada, Kazuhiko Nakao   +7 more
doaj   +1 more source

Shining Light on Autophagy in Skin Pigmentation and Pigmentary Disorders

Cells, 2022
Autophagy is a vital process for cell survival and it preserves homeostasis by recycling or disassembling unnecessary or dysfunctional cellular constituents.
Daniela Kovacs, Giorgia Cardinali, Mauro Picardo, Emanuela Bastonini   +3 more
doaj   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Adjustment of Coatings Morphology and Particle Distribution of Layered Silicates by Freeze‐Drying for Improved Gas Barriers

Advanced Engineering Materials, EarlyView.
Freeze‐drying of layered silicate is the key to get coatings with superior gas barrier. Freeze‐drying of layered silicates modified with dodecylamine (DDA) is a highly effective technique for the preparation of barrier pigments that significantly mitigate the permeation of oxygen, water vapor, and hydrogen through polymer films containing these ...
Joshua Lommes, Moritz Bätcher, Andrea Deißenberger, Volkmar Stenzel, Andreas Hartwig   +4 more
wiley   +1 more source