Systematic Optimization of Proteolysis-Targeting Chimeras for PIN1 Enables Selective Degradation and Antitumor Activity In Vivo. [PDF]
PharmaceuticsBackground: The peptidyl–prolyl cis–trans isomerase PIN1 regulates multiple oncogenic and tumor-suppressive pathways and is frequently overexpressed in human cancers.
Ma Y +10 more
europepmc +2 more sources
Prolyl Isomerase Pin1 is Highly Expressed in Her2-Positive Breast Cancer and Regulates erbB2 Protein Stability [PDF]
Molecular Cancer, 2013 Overexpression of HER-2/Neu occurs in about 25–30% of breast cancer patients and is indicative of poor prognosis. While Her2/Neu overexpression is primarily a result of erbB2 amplification, it has recently been recognized that erbB2 levels are also ...
Burga, Laura N +5 more
core +3 more sources
Protein Never in Mitosis Gene A Interacting-1 regulates calpain activity and the degradation of cyclooxygenase-2 in endothelial cells [PDF]
Journal of Inflammation, 2009 Background The peptidyl-proline isomerase, Protein Never in Mitosis Gene A Interacting-1 (PIN1), regulates turnover of inducible nitric oxide synthase (iNOS) in murine aortic endothelial cells (MAEC) stimulated with E. coli endotoxin (LPS) and interferon-
Likhotvorik Rostislav I +6 more
core +4 more sources
THE MODEL FOR AUXIN REGULATED AtPIN1 EXPRESSION IN THE ROOT APICAL MERISTEM [PDF]
Journal of Stress Physiology & Biochemistry, 2012 Plant hormone auxin regulates many aspects of plant growth and development. PIN-FORMED (PIN) gene family encodes transmembrane proteins, which mediate auxin efflux.
A.V. Doroshkov +6 more
core +2 more sources
Circulating Pin1 Levels in Patients With Chronic Thromboembolic Pulmonary Hypertension: A Case-Control Study. [PDF]
Pulm CircChronic thromboembolic pulmonary hypertension (CTEPH) is a rare but severe complication of pulmonary embolism (PE), yet its underlying mechanisms remain poorly understood.
Willems L +11 more
europepmc +2 more sources
陆军军医大学学报, 2022 Objective To knock out PIN1 gene of porcine fetal fibroblasts (PFFs) by clustered regular interval short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system in order to establish PIN1 knockout porcine fetal fibroblast cell lines ...
WANG Wanyi +5 more
doaj +1 more source
Effects of Pin1 on Proliferation and Apoptosis of HepG2 Cells Under Endoplasmic Reticulum Stress
Zhongliu Fangzhi Yanjiu, 2022 Objective To investigate the expression of Pin1 protein in HepG2 cells under endoplasmic reticulum stress (ERS) and its effect on cell proliferation and apoptosis. Methods The THLE3 cells were treated with tunicamycin (TM) (TM group) or DMSO (DMSO group)
JIANG Mingting, HUANG Jin, ZHENG Shuping
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Frontiers in Cell and Developmental Biology, 2022 More than 20 years since its discovery, our understanding of Pin1 function in various diseases continues to improve. Pin1 plays a crucial role in pathogenesis and has been implicated in metabolic disorders, cardiovascular diseases, inflammatory diseases,
Yew Mun Lee +3 more
doaj +1 more source
Identification and inhibition of PIN1-NRF2 protein-protein interactions through computational and biophysical approaches. [PDF]
Sci RepNRF2 is a transcription factor responsible for coordinating the expression of over a thousand cytoprotective genes. Although NRF2 is constitutively expressed, its stability is modulated by the redox-sensitive protein KEAP1 and other conditional binding ...
Ozleyen A +5 more
europepmc +2 more sources
Inhibition of the PIN1-NRF2/GPX4 axis imparts sensitivity to cisplatin in cervical cancer cells
Acta Biochimica et Biophysica Sinica, 2022 The incidence of cervical cancer (CC) ranks the fourth in female malignant tumors globally. Chemoresistance is one of the main causes of treatment failure in advanced recurrent CC. Prolyl isomerase 1 (PIN1) is overexpressed in a variety of tumors, and is
Zhang Zheng +3 more
doaj +1 more source