Single-cell-based system to monitor carrier driven cellular auxin homeostasis [PDF]
, 2013 Background: Abundance and distribution of the plant hormone auxin play important roles in plant development. Besides other metabolic processes, various auxin carriers control the cellular level of active auxin and, hence, are major regulators of cellular
Barbez, Elke +7 more
core +3 more sources
Cellular mechanisms for cargo delivery and polarity maintenance at different polar domains in plant cells [PDF]
, 2016 The asymmetric localization of proteins in the plasma membrane domains of eukaryotic cells is a fundamental manifestation of cell polarity that is central to multicellular organization and developmental patterning.
Friml, Jiri +6 more
core +4 more sources
Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy
Biomedicines, 2021 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) specifically binds and isomerizes the phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif, which leads to changes in protein conformation and function. Pin1 is widely overexpressed in
Hsiang-Hao Chuang +6 more
doaj +1 more source
Pin1 Promotes NLRP3 Inflammasome Activation by Phosphorylation of p38 MAPK Pathway in Septic Shock
Frontiers in Immunology, 2021 Pin1 is the only known peptidyl-prolyl cis-trans isomerase (PPIase) that can specifically recognize and isomerize the phosphorylated Serine/Threonine-Proline (pSer/Thr-Pro) motif, change the conformation of proteins through protein phosphorylation, thus ...
Ruijie Dong +6 more
doaj +1 more source
Pattern formation during de novo assembly of the Arabidopsis shoot meristem [PDF]
, 2007 Most multicellular organisms have a capacity to regenerate tissue after wounding. Few, however, have the ability to regenerate an entire new body from adult tissue. Induction of new shoot meristems from cultured root explants is a widely used, but poorly
Das, Pradeep +5 more
core +2 more sources
Targeting PIN1 as a Therapeutic Approach for Hepatocellular Carcinoma
Frontiers in Cell and Developmental Biology, 2020 PIN1 is a peptidyl-prolyl cis/trans isomerase that specifically binds and catalyzes the cis/trans isomerization of the phosphorylated serine or threonine residue preceding a proline (pSer/Thr-Pro) motif of its interacting proteins.
Chi-Wai Cheng, Eric Tse
doaj +1 more source
Brown Algae Polyphenol, a Prolyl Isomerase Pin1 Inhibitor, Prevents Obesity by Inhibiting the Differentiation of Stem Cells into Adipocytes. [PDF]
PLoS ONE, 2016 While screening for an inhibitor of the peptidyl prolyl cis/trans isomerase, Pin1, we came across a brown algae polyphenol that blocks the differentiation of fibroblasts into adipocytes.
Atsuko Suzuki +4 more
doaj +1 more source
Interplay of the two ancient metabolites auxin and MEcPP regulates adaptive growth. [PDF]
, 2018 The ancient morphoregulatory hormone auxin dynamically realigns dedicated cellular processes that shape plant growth under prevailing environmental conditions. However, the nature of the stress-responsive signal altering auxin homeostasis remains elusive.
de Souza, Amancio +9 more
core +2 more sources
Pin1 Flips Alzheimer’s Switch [PDF]
ACS Chemical Biology, 2006 The biochemical processes leading to Alzheimer's disease are just now being elucidated. A recent study shows that a peptidyl-prolyl isomerase, Pin1, specifically regulates the degradation of amyloid precursor protein (APP). An alternative model for Pin1 regulation of APP processing is also proposed.
openaire +2 more sources
Cell polarity and patterning by PIN trafficking through early endosomal compartments in Arabidopsis thaliana [PDF]
, 2013 PIN-FORMED (PIN) proteins localize asymmetrically at the plasma membrane and mediate intercellular polar transport of the plant hormone auxin that is crucial for a multitude of developmental processes in plants.
De Rycke, Riet +8 more
core +5 more sources