Results 41 to 50 of about 204,136 (221)
Glia-pinealocyte network: the paracrine modulation of melatonin synthesis by tumor necrosis factor (TNF). [PDF]
PLoS ONE, 2012 The pineal gland, a circumventricular organ, plays an integrative role in defense responses. The injury-induced suppression of the pineal gland hormone, melatonin, which is triggered by darkness, allows the mounting of innate immune responses.
Sanseray da Silveira Cruz-Machado +4 more
doaj +1 more source
PINEAL GLAND IN PEDIATRICS [PDF]
The Journal of Nervous and Mental Disease, 1920 n ...
openaire +2 more sources
Profiling Temporal Changes of the Pineal Transcriptomes at Single Cell Level Upon Neonatal HIBD
Frontiers in Cell and Developmental Biology, 2022 Neonatal hypoxic-ischemic brain damage (HIBD) often results in various neurological deficits. Among them, a common, yet often neglected, symptom is circadian rhythm disorders. Previous studies revealed that the occurrence of cysts in the pineal gland, an
Xin Ding +14 more
doaj +1 more source
Macro-microscopical aspects of the buffalo (Bubalus bubalis Linnaeus, 1758) pineal gland [PDF]
Biotemas, 2009 Gross and microscopical aspects of the buffalo pineal gland were described in seasonal parturition animals, since this gland is responsible for melatonin secretion which acts upon the hypothalamus-hypophysis reproductive axis feedback system.
Ana Flávia de Carvalho +4 more
doaj +2 more sources
Advanced Science, EarlyView.A series of melatonin‐conjugated platinum(IV) prodrugs was functionalized with isocyanate chains (compounds 5‒12). MP‐12C (compound 11) was identified as the lead candidate, with optimal potency and safety. MP‐12C exhibited greater efficacy than cisplatin by increasing intracellular uptake, reshaping the extracellular matrix, activating the cGAS‐STING ...
Linhui Wang +18 more
wiley +1 more source
Biallelic PAX6 Variants in an Adult With Severe Microphthalmia and Preserved Intellectual Function
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT PAX6 encodes a dosage‐sensitive transcription factor that is essential for eye development. Heterozygous PAX6 disease is well characterized, but biallelic disease is extremely rare and has been associated with anophthalmia, severe brain malformations, and perinatal lethality.
Karl De Geer +4 more
wiley +1 more source
Exceptional preservation informs the paleobiology of tapinocephalid dinocephalians
The Anatomical Record, EarlyView.Abstract The tapinocephalid dinocephalian Moschops is one of the most iconic taxa of the middle Permian, yet its paleobiology remains one of the least well‐known. Here, we address some aspects of paleoneurology and paleobiology of Moschops using CT scanning of four well preserved skulls from the upper Abrahamskraal Formation of South Africa. Two of the
Julien Benoit +6 more
wiley +1 more source
Frontiers in Oncology, 2021 IntroductionPineal gland tumors are exceedingly rare and account for 0.4-1.0% of brain neoplasms. Their rarity has confounded a clear understanding of the prognostic factors and standards of care for these neoplasms.
Huy Gia Vuong +3 more
doaj +1 more source
The Anatomical Record, EarlyView.Abstract Nineteenth century excavations of the Ciply‐Malogne Phosphatic Chalk Formation in Hainaut, Belgium, yielded over 50 partial mosasaur skeletons, the majority of which were referred to the species Mosasaurus lemonnieri Dollo, 1889. In the years since, this taxon has experienced a complicated taxonomic history, and its exceptional hypodigm has ...
Henry S. Sharpe +3 more
wiley +1 more source