Results 61 to 70 of about 191,019 (230)

A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics

Andrology, EarlyView.
ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis, Lisa Schneider, Felix Bremmer, Daniel Nettersheim   +3 more
wiley   +1 more source

Pink1/Parkin signaling mediates pineal mitochondrial autophagy dysfunction and its biological role in a comorbid rat model of depression and insomnia

Brain Research Bulletin
Using a chronic unpredictable mild stress (CUMS) combined with multi-platform water environment sleep deprivation (SD) as an animal model, the occurrence and development of human depression combined with insomnia were simulated.
Zirong Li, Yi Shu, Deguo Liu, Sheng Xie, Liangbo Xian, Jiaqi Luo, Xiuwen Huang, Haixing Jiang   +7 more
doaj   +1 more source

Temporal–spatial characterization of chicken clock genes: circadian expression in retina, pineal gland, and peripheral tissues

, 2003
The molecular core of the vertebrate circadian clock is a set of clock genes, whose products interact to control circadian changes in physiology. These clock genes are expressed in all tissues known to possess an endogenous self-sustaining clock, and ...
Chaurasia, S.S., Shyam S. Chaurasia, Haque, R., Rashidul Haque, Iuvone, P.M., Chong, Nelson W., David C. Klein, Nelson W. Chong, P. Michael Iuvone, Klein, D.C.   +9 more
core   +1 more source

Characterization of expressed sequence tags from a gallus gallus pineal gland cDNA library [PDF]

, 2005
The pineal gland is the circadian oscillator in the chicken, regulating diverse functions ranging from egg laying to feeding. Here, we describe the isolation and characterization of expressed sequence tags (ESTs) isolated from a chicken pineal gland cDNA
Greg Touchton (7661453), Ed Smith, Ed Smith (3617795), Stefanie Hartman, G. Touchton (7675382), T. Geng (5938043), Nelson W. Chong, S. Hartman (7675379), Tuoyu Geng, J. Wynn (7675385), Greg Touchton, Jessica Wynn, Nelson W. Chong (7609583), Jessica Wynn (7661456), E. Smith (2403358), Wynn, J., Stefanie Hartman (7661450), Geng, T., Chong, Nelson W., Tuoyu Geng (257034), Hartman, S., Touchton, G., Smith, E.   +22 more
core   +2 more sources

Basal body temperature as a biomarker of reproductive state in ewes: A multi‐method comparison

Australian Veterinary Journal, EarlyView.
This study quantified body temperature dynamics throughout reproductive stages in crossbred ewes based on complementary monitoring techniques. Five ewes from a semi‐extensive farming system were included in two sub‐trials: animals were first assessed in the prepubertal stage and, subsequently, an oestrous cycle was induced by intravaginal progesterone ...
E Pérez‐García, J Nieto de la Losa, JA Abecia, J Plaza, C Palacios Riocerezo   +4 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

Diagnostic Yield of Brain MRI in Pediatric Short Stature: Hypothalamic–Pituitary Lesions and Incidental Findings in Real‐World Practice

Clinical Endocrinology, EarlyView.
ABSTRACT Background Brain MRI is widely performed in children with short stature or suspected growth hormone deficiency(GHD) to exclude hypothalamic–pituitary (HP) pathology, yet its diagnostic yield in routine practice is uncertain. We aimed to evaluate the prevalence, clinical significance, and distribution of HP and extrahypothalamic abnormalities ...
Mustafa Zubeidat, Tamer Sobeh, Shai Shrot   +2 more
wiley   +1 more source

Pineal gland research with high resolution 3D imaging techniques

, 2020
The pineal gland is an endocrine gland in the brain, which produces melatonin under the control of the central clock and the suprachiasmatic nucleus [1].
Buzmakov A, Cedola A, Fratini M, Bukreeva I, Palermo F, Chukalina M, A Ingacheva, Asadchikov V   +7 more
core  

The hormonal Zeitgeber melatonin: role as a circadian modulator in memory processing [PDF]

, 2012
The neuroendocrine substance melatonin is a hormone synthesized rhythmically by the pineal gland under the influence of the circadian system and alternating light/dark cycles. Melatonin has been shown to have broad applications, and consequently becoming
Rawashdeh, Oliver, Erik Maronde, Maronde, Erik, Oliver eRawashdeh, Erik eMaronde, Oliver Rawashdeh   +5 more
core   +1 more source