Results 61 to 70 of about 19,371 (184)

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Neuromodulation of the Pineal Gland via Electrical Stimulation of Its Sympathetic Innervation Pathway

Frontiers in Neuroscience, 2020
Stimulation of the pineal gland via its sympathetic innervation pathway results in the production of N-acetylserotonin and melatonin. Melatonin has many therapeutic roles and is heavily implicated in the regulation of the sleep-wake cycle. In addition, N-
Susannah C. Lumsden, Susannah C. Lumsden, Andrew N. Clarkson, Andrew N. Clarkson, Andrew N. Clarkson, Yusuf Ozgur Cakmak, Yusuf Ozgur Cakmak, Yusuf Ozgur Cakmak, Yusuf Ozgur Cakmak   +8 more
doaj   +1 more source

Cancer Risk in Marfan Syndrome: A Swedish Population‐Based Cohort Study

International Journal of Cancer, Volume 159, Issue 7, Page 1707-1714, 1 October 2026.
The cancer risk in Marfan syndrome, an autosomal dominant connective tissue disorder, largely remains to be explored. In this population‐based matched cohort study of 1544 Swedish patients, the overall cancer risk in adults with Marfan syndrome showed no significant increase, except for the risk of endocrine tumours with a nearly threefold increase ...
Ida Nordgren, Anna Skarin Nordenvall, Alexandra Wachtmeister, Fulya Taylan, Yunxia Lu, Christina Norrby, Anna Lindstrand, Giedre Grigelioniene, Giorgio Tettamanti   +8 more
wiley   +1 more source

Protein and mRNA expression of estradiol receptors during estrus in yaks (Bos grunniens)

Revista Brasileira de Zootecnia, 2015
The objective of this study was to investigate mRNA by real-time PCR and protein expression by immunofluorescence of the estradiol receptors (ER) in the pineal gland, hypothalamus, pituitary gland, and gonads of yaks (Bos grunniens).
Shengdong Huo, Qijian Yuan, Taojie Zhang, Junlin Liu, Ayimuguli Abudureyimu, Jutian Yang   +5 more
doaj   +1 more source

Specific Knockdown of Gene Expression in the Mature Rat Pineal Gland: The Cone‐Rod Homeodomain Transcription Factor Regulates Melatonin Synthesis In Vivo

Journal of Pineal Research, Volume 78, Issue 5, September 2026.
ABSTRACT Melatonin is synthesised from tryptophan by the sequential action of enzymes that are highly expressed in the pineal gland. Homeobox gene‐encoded transcription factors typically control organ development; however, a set of homeobox genes is strongly expressed in the adult pineal gland.
Nicole Anne Morrissey, Tenna Bering, Aurea Susana Blancas‐Velázquez, Jakob Albrethsen, Nicolai J. Wewer Albrechtsen, Martin Fredensborg Rath   +5 more
wiley   +1 more source

Scientific Research on the Pineal Gland: A Bibliometric Analysis from Its First Publication

Endocrinology Research and Practice
Objective: The bibliometric perspective examines publications using a quantitative way and statistics to analyze them. The purpose of the current study was to perform a comprehensive overview of the research on the pineal gland through bibliometric ...
Esra Şen, Sinem Nur Sever, Begümhan Turhan   +2 more
doaj   +3 more sources

Innervation of the pineal gland in the rat: A chromotolysis study

مجله كليه طب الكندي, 2011
Back ground: The innervations of the pineal gland from the superior cervical ganglion have shown some form of a chromatolysis reaction. Objective: 1-Tracing the innervations of the pineal gland by removing the target tissue (the pineal gland in this ...
Hadi J. Ali
doaj  

Multimodal treatment of pineal metastasis from oesophageal adenocarcinoma

Drugs in Context
The pineal gland is a neuroendocrine gland located in the epithalamus. Primary pineal tumours are uncommon and metastatic cancer spreading to the pineal gland is even more unusual.
Francesca Rifaldi, Domiziana Alaimo, Anna Tortorella, Ilaria Imarisio, Anna Pagani, Salvatore Corallo, Paolo Pedrazzoli, Daniela Cicognini, Viola Custodi, Francesco Guerrini, Giannantonio Spena, Elisabetta Bonzano, Sara Colombo, Jacopo Viganò, Luca Ansaloni, Anna Gallotti, Alessandra Viglio, Francesco Serra   +17 more
doaj   +1 more source

Endogenous melatonin partial metabolic clearance as a potential endogenous marker of CYP1A2 activity

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2899-2908, August 2026.
Aims Cytochrome P450 1A2 (CYP1A2) exhibits substantial interindividual variability, necessitating appropriate phenotyping strategies for personalized pharmacotherapy. This study evaluated endogenous melatonin partial metabolic clearance (CLm(MEL)), calculated from urinary 6‐hydroxymelatonin (6‐O‐MEL) excretion and plasma melatonin (MEL) exposure, as a ...
Akitomo Yokokawa, Hayato Shimazaki, Shunji Igarashi, Yoshiki Tagawa, Naoki Hisada, Hiromi Shibasaki   +5 more
wiley   +1 more source

Melatonin and Lactation in Ruminants Dairy Animals: A Systematic Review and Meta‐Analysis of Preclinical Studies

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Melatonin is present in breast milk with a diurnal pattern, potentially supporting early circadian rhythm development. This systematic review and meta‐analysis aimed to evaluate the effects of exogenous melatonin supplementation, compared with no treatment or placebo, on milk yield, milk composition, somatic cell count ...
Reza Sattarpour, Maryam Noori, Parvaneh Sadeghimoghadam, Nasim Sattarpour, Parvin Bastani   +4 more
wiley   +1 more source