Results 81 to 90 of about 508,086 (240)

Prolonged exposure to artificial light and carcinogenesis: A systematic review of oncostatic mechanisms associated with melatonin pathways

Photochemistry and Photobiology, EarlyView.
Exposure to artificial light at night (ALAN), particularly at blue wavelengths, disrupts circadian rhythms by suppressing melatonin, thereby increasing cancer susceptibility. This systematic review consolidates evidence linking prolonged ALAN exposure to an elevated risk of breast and prostate tumors.
Gabriel Barboza, Jêmina Oliveira, Antônio Ferreira, Renan Lopes, Marli Cupertino   +4 more
wiley   +1 more source

Peculiarities of psammoma bodies distribution in the human pineal gland: a new approach to determining the functional significance of pineal gland calcifications

Сибирский научный медицинский журнал
The pineal gland is a neuroendocrine gland that synchronizes the functional activity of body organs with the light regime using the hormone melatonin, which is actively released into the bloodstream at night. Melatonin is synthesized by pinealocytes, the
D. A. Sufieva, E. A. Fedorova, I. P. Grigorev, D. E. Korzhevskii   +3 more
doaj   +1 more source

The reno-pineal axis: A novel role for melatonin

Indian Journal of Endocrinology and Metabolism, 2012
The pineal gland is a tiny endocrine gland whose physiologic role has been the focus of much research and much more speculation over the past century.
Sanjay Kalra, Swati Agrawal, Manisha Sahay   +2 more
doaj   +1 more source

Circadian-Related Heteromerization of Adrenergic and Dopamine D4 Receptors Modulates Melatonin Synthesis and Release in the Pineal Gland

PLoS Biology, 2012
Dopamine and adrenergic receptor complexes form under a circadian-regulated cycle and directly modulate melatonin synthesis and release from the pineal gland.
Sergio González, D. Moreno-Delgado, E. Moreno, Kamil Pérez‐Capote, R. Franco, J. Mallol, Antonio Cortés, V. Casadó, C. Lluis, J. Ortiz, S. Ferré, E. Canela, P. McCormick   +12 more
semanticscholar   +1 more source

The role of agomelatine in appetite regulation and body weight in rats

Experimental Physiology, EarlyView.
Abstract The hypothalamic nuclei play a central role in the synthesis of anorexigenic and orexigenic neuropeptides, which are regulated by peripheral hormones, like leptin and ghrelin. Melatonergic receptors (MT1/MT2) are prominently expressed in the arcuate nucleus of the hypothalamus – an essential hub for appetite control – and in peripheral ...
Engin Korkmaz, Yavuz Erden, Çiğdem Tekin, Suat Tekin   +3 more
wiley   +1 more source

In silico genome wide mining of conserved and novel miRNAs in the brain and pineal gland of Danio rerio using small RNA sequencing data

Genomics Data, 2016
MicroRNAs (miRNAs) are small, non-coding RNA molecules that bind to the mRNA of the target genes and regulate the expression of the gene at the post-transcriptional level. Zebrafish is an economically important freshwater fish species globally considered
Suyash Agarwal, Naresh Sahebrao Nagpure, Prachi Srivastava, Basdeo Kushwaha, Ravindra Kumar, Manmohan Pandey, Shreya Srivastava   +6 more
doaj   +1 more source

The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker, Andrew F. James, Svetlana Mastitskaya   +2 more
wiley   +1 more source

Scientific Research on the Pineal Gland: A Bibliometric Analysis from Its First Publication

Endocrinology Research and Practice
Objective: The bibliometric perspective examines publications using a quantitative way and statistics to analyze them. The purpose of the current study was to perform a comprehensive overview of the research on the pineal gland through bibliometric ...
Esra Şen, Sinem Nur Sever, Begümhan Turhan   +2 more
doaj   +1 more source

MicroRNAs in the Pineal Gland

Journal of Biological Chemistry, 2012
Background: MicroRNAs have not been studied in the pineal gland, the source of circulating melatonin. Results: The pineal miRNA population is profiled; developmental and tissue-specific patterns are described.
Samuel J. H. Clokie, Pierre Lau, Hyun Hee Kim, S. Coon, David C. Klein   +4 more
semanticscholar   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source