Results 101 to 110 of about 37,375 (191)

Increased cysteine metabolism in PINK1 models of Parkinson's disease

Disease Models & Mechanisms, 2023
Marco Travaglio, Filippos Michopoulos, Yizhou Yu, Rebeka Popovic, Edmund Foster, Muireann Coen, L. Miguel Martins   +6 more
doaj   +1 more source

Functional role of PGAM5 multimeric assemblies and their polymerization into filaments. [PDF]

, 2019
PGAM5 is a mitochondrial protein phosphatase whose genetic ablation in mice results in mitochondria-related disorders, including neurodegeneration. Functions of PGAM5 include regulation of mitophagy, cell death, metabolism and aging.
Agnew, Christopher, Frost, Adam, Herrera, Clara, Ingaramo, Maria, Jura, Natalia, Miller-Vedam, Lakshmi, Ruiz, Karen, Thaker, Tarjani M, Toso, Daniel, Trenker, Raphael   +9 more
core   +3 more sources

PINK1 function in health and disease

EMBO Molecular Medicine, 2009
The role of mitochondria in sporadic Parkinson's disease (PD) has been debated for a little over 20 years since the description of complex I deficiency in the substantia nigra pars compacta (SNpc) of PD patients. However, the identification of recessive pathogenic mutations in the pink1 gene in familial PD cases firmly re-ignited interest in the ...
Deas, Emma, Plun-Favreau, Helene, Wood, Nicholas W   +2 more
openaire   +2 more sources

Regulation of Mitochondrial Dynamics and Neurodegenerative Diseases [PDF]

, 2011
Mitochondria are important cellular organelles in most metabolic processes and have a highly dynamic nature, undergoing frequent fission and fusion. The dynamic balance between fission and fusion plays critical roles in mitochondrial functions. In recent
Fujimura, Atsushi, Han, Xiao-Jian, Matsui, Hideki, Matsushita, Masayuki, Nishiki, Tei-ichi, Ohmori, Iori, Tomizawa, Kazuhito   +6 more
core   +1 more source

PINK1 mediates neuronal survival in monkey [PDF]

Protein & Cell, 2021
Sun, Zhiyu, Ye, Jiangyu, Yuan, Junying
openaire   +2 more sources

The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway.

PLoS ONE, 2010
Loss-of-function mutations in the PINK1 or parkin genes result in recessive heritable forms of parkinsonism. Genetic studies of Drosophila orthologs of PINK1 and parkin indicate that PINK1, a mitochondrially targeted serine/threonine kinase, acts ...
Angela C Poole, Ruth E Thomas, Selina Yu, Evelyn S Vincow, Leo Pallanck   +4 more
doaj   +1 more source

A positive feedback loop between SMAD3 and PINK1 in regulation of mitophagy

Cell Discovery
PTEN-induced kinase-1 (PINK1) is a crucial player in selective clearance of damaged mitochondria via the autophagy-lysosome pathway, a process termed mitophagy.
Mingzhu Tang, Dade Rong, Xiangzheng Gao, Guang Lu, Haimei Tang, Peng Wang, Ning-Yi Shao, Dajing Xia, Xin-Hua Feng, Wei-Feng He, Weilin Chen, Jia-Hong Lu, Wei Liu, Han-Ming Shen   +13 more
doaj   +1 more source

Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice.

PLoS ONE, 2011
BackgroundPTEN-induced kinase 1 (PINK1) is linked to recessive Parkinsonism (EOPD). Pink1 deletion results in impaired dopamine (DA) release and decreased mitochondrial respiration in the striatum of mice. To reveal additional mechanisms of Pink1-related
Ravi S Akundi, Zhenyu Huang, Joshua Eason, Jignesh D Pandya, Lianteng Zhi, Wayne A Cass, Patrick G Sullivan, Hansruedi Büeler   +7 more
doaj   +1 more source

Tickled PINK1 [PDF]

Nature Chemical Biology, 2013
openaire   +1 more source

Bioenergetic Consequences of PINK1 Mutations in Parkinson Disease [PDF]

, 2011
Background: Mutations of the gene for PTEN-induced kinase 1 (PINK1) are a cause of familial Parkinson's disease (PD). PINK1 protein has been localised to mitochondria and PINK1 gene knockout models exhibit abnormal mitochondrial function.
Abramov, AY, Gegg, M, Grunewald, A, Klein, C, Schapira, AHV, Wood, NW   +5 more
core