Results 121 to 130 of about 23,205 (164)

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid-β Pathology. [PDF]

open access: yesAdv Sci (Weinh)
Li Y   +25 more
europepmc   +1 more source

PINK1: The guard of mitochondria

Life Sciences, 2020
PTEN-induced putative kinase 1 (PINK1) performs many important functions in cells and has been highlighted for its role in early-onset Parkinson's disease. In recent years, an increasing number of studies have revealed the involvement of PINK1 in regulation of a variety of cell physiological and pathophysiological processes, of which regulation of ...
Nan, Wang   +8 more
openaire   +2 more sources

FUNDC1 collaborates with PINK1 in regulating mitochondrial Fission and compensating for PINK1 deficiency

Biochemical and Biophysical Research Communications, 2023
Parkinson's disease is presently thought to have its molecular roots in the alteration of PINK1-mediated mitophagy and mitochondrial dynamics. Finding new suppressors of the pathway is essential for developing cutting-edge treatment approaches. Our study shows that FUNDC1 suppressed PINK1 mutant phenotypes in Drosophila.
Jing, Xu   +4 more
openaire   +2 more sources

In the PINK1

Science, 2014
Mitochondria lacking a Parkinson’s disease–associated kinase harbor a functionally important phosphorylation defect.
openaire   +2 more sources

Hsp70 participates in PINK1-mediated mitophagy by regulating the stability of PINK1

Neuroscience Letters, 2018
Loss-of function mutations in PTEN-induced putative kinase 1 (PINK1) is one of the most common causes of autosomal recessive Parkinson's disease (PD). PINK1-mediated mitophagy is critical to mitochondrial quality control and plays an important role in PD pathogenesis.
Qian, Zheng   +6 more
openaire   +2 more sources

PINK1 and Parkin: The odd couple

Neuroscience Research, 2020
In 2004, PINK1 was established as a gene linked to early onset of autosomal recessive juvenile Parkinsonism. Since then, tremendous efforts allowed involving the gene product in diverse events but with a strong focus on its partnership with the protein Parkin for the degradation of damaged mitochondria through mitophagy.
Yoboue, Edgar Djaha, Valente, Enza Maria
openaire   +3 more sources

Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology [PDF]

open access: yesCell Reports, 2018
PINK1 and Parkin mediate mitophagy, the cellular process that clears dysfunctional mitochondria. Mitophagy is regulated by mitochondrial dynamics, but the molecules linking these two processes remain poorly understood. Here, we show that Sam50, the core component of the sorting and assembly machinery (SAM), is a critical regulator of mitochondrial ...
Dan Chen, Chaojun Yan, Bin Lu
exaly   +4 more sources

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