Results 141 to 150 of about 38,037 (258)

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, EarlyView.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

A CRISPR monkey model unravels a unique function of PINK1 in primate brains

Molecular Neurodegeneration, 2019
Genetically modified rodent models have been valuable for investigating the pathogenesis of neurodegenerative diseases such as Parkinson’s disease (PD). Based on the fact that mutations in the PINK1 gene cause autosomal recessive juvenile parkinsonism, a
Weili Yang, Shihua Li, Xiao-Jiang Li
doaj   +1 more source

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, EarlyView.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

Recovering the mass and the charge of a Reissner-Nordstr\"om black hole by an inverse scattering experiment

, 2007
In this paper, we study inverse scattering of massless Dirac fields that propagate in the exterior region of a Reissner-Nordstr\"om black hole. Using a stationary approach we determine precisely the leading terms of the high-energy asymptotic expansion ...
Bachelot A, Bachelot A, Bachelot A, Daudé T, Dereziński J, Dimock J, Finster F Kamran N Smoller J Yau S-T, François Nicoleau, Gel'fand I M, Häfner D, Häfner D, Isozaki H, Nicolas J-P, Nicoleau F, O'Neill B, Robert D, Thierry Daudé, Wald R   +17 more
core   +1 more source

PINK1 mediates neuronal survival in monkey [PDF]

Protein & Cell, 2021
Sun, Zhiyu, Ye, Jiangyu, Yuan, Junying
openaire   +2 more sources

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

VIEW, EarlyView.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li, Yulan Liu, Yuran Li, Yingjie Hua, Xinquan Jiang, Mingliang Zhou   +5 more
wiley   +1 more source

Mitochondrial transfer in acute myeloid leukaemia and multiple myeloma: Mechanisms, consequences and potential therapeutic opportunities

The FEBS Journal, EarlyView.
Mitochondria can be transferred from bone marrow cells to cancer cells in acute myeloid leukaemia and multiple myeloma, boosting tumour energy production, growth, and drug resistance. This review highlights key transfer mechanisms and shows how targeting mitochondrial movement and dynamics may offer new therapeutic strategies to limit cancer ...
Ebubechukwu Nwarunma, Mark T. S. Williams   +1 more
wiley   +1 more source

Role of the UHRF1–KLHL6–CORO2B axis in obesity‐related insulin resistance

Journal of Diabetes Investigation, EarlyView.
In high‐fat diet (HFD)‐induced obese mice with insulin resistance, overexpression of UHRF1 may recruit DNMT1 to promote DNA methylation of KLHL6, leading to its downregulation. Subsequently, suppression of KLHL6 may decrease the ubiquitination of CORO2B, resulting in elevated CORO2B protein levels.
Xu Deng, Xiaoping Li, Jialuo Cai, Xinyu Chen, Zelin Xu, Yuntao Luo   +5 more
wiley   +1 more source

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

One day of environment‐induced heat stress causes injury to the murine kidney

Experimental Physiology, EarlyView.
Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths, Alyona Michael, Zachary J. Schlader, Joshua T. Selsby   +3 more
wiley   +1 more source