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The PINK1–Parkin axis: An Overview
Neuroscience Research, 2020Parkin is a protein involved in familial Parkinson's disease (PD), a neurodegenerative disorder with motor symptoms linked to the loss of dopaminergic neurons. More than 20 years have passed since the discovery of Parkin; since that time, another familial PD protein has been identified: PINK1, which acts upstream of Parkin.
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iPS models of Parkin and PINK1
Biochemical Society Transactions, 2015Parkinson disease (PD) is a degenerative disorder of the central nervous system resulting from depletion of dopaminergic neurons and currently remains incurable despite enormous international research efforts. The development of induced pluripotent stem cell (iPSC) technology opened up the unique possibility of studying disease mechanisms in human ...
Aleksandar, Rakovic +2 more
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Science Signaling, 2009
FOXO3a-dependent induction of Pink1 helps protect lymphocytes from apoptosis after IL-2 deprivation.
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FOXO3a-dependent induction of Pink1 helps protect lymphocytes from apoptosis after IL-2 deprivation.
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PINK1 signalling in cancer biology
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2014PTEN-induced kinase 1 (PINK1) was identified initially in cancer cells as a gene up-regulated by overexpression of the major tumor suppressor, PTEN. Loss-of-function mutations in PINK1 were discovered subsequently to cause autosomal recessive Parkinson's disease.
Ciara H, O'Flanagan, Cora, O'Neill
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Genetic mutations and functions of PINK1
Trends in Pharmacological Sciences, 2011Parkinson's disease (PD) is the second most common neurodegenerative disease. Mutations in PINK1 (PARK6) are the second most frequent cause of autosomal recessive, young-onset PD, after parkin (PARK2). PINK1 (a kinase with an N-terminal mitochondrial targeting sequence) provides protection against mitochondrial dysfunction and regulates mitochondrial ...
Sumihiro, Kawajiri +3 more
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Autophagy
Mutations in the PINK1 kinase cause Parkinson disease (PD) through physiological processes that are not yet fully elucidated. PINK1 kinase accumulates selectively on damaged mitochondria, where it recruits the E3 ubiquitin ligase PRKN/Parkin to mediate mitophagy.
Mohamed A. Eldeeb +5 more
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Mutations in the PINK1 kinase cause Parkinson disease (PD) through physiological processes that are not yet fully elucidated. PINK1 kinase accumulates selectively on damaged mitochondria, where it recruits the E3 ubiquitin ligase PRKN/Parkin to mediate mitophagy.
Mohamed A. Eldeeb +5 more
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Induction of PINK1/Parkin-Mediated Mitophagy
2017PINK1/Parkin mitophagy is a key mechanism to contribute mitochondrial quality control, and the defects are thought to be a cause of those Parkinson's disease onsets. Upon loss of mitochondrial membrane potential, PINK1 and Parkin are activated to promote the proteasomal degradation of mitochondrial outer membrane proteins and selective elimination of ...
Shigeto, Sato, Norihiko, Furuya
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[PINK1 and the related diseases].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2017As a kind of mitochondrial membrane protein with protein kinase activity, phosphatase and tensin homolog deleted on chromosome ten induced kinase 1 (PINK1) is involved in many biological metabolic processes. Since PINK1 had been found to be associated with Parkinson's disease, researchers have been exploring its biological function.
Yang, Huang, De-Zhi, Mu
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[Molecular genetics of PINK1].
Brain and nerve = Shinkei kenkyu no shinpo, 2007PTEN-induced putative kinase 1 (PINK1) is a causative gene for autosomal recessive early onset parkinsonism. Mutations in PINK1 were identified originally in PARK6-linked parkinsonism families from Italy and Spain. PINK1 contains 8 exons spanning 1.8 kb, and encodes a protein of 581 amino acids with a mitochondrial targeting motif and a serine ...
Manabu, Funayama, Nobutaka, Hattori
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