Results 111 to 120 of about 37,375 (191)

Characterization of Vesicular Monoamine Transporter 2 and its role in Parkinson\u27s Disease Pathogenesis using Drosophila [PDF]

, 2016
Parkinson’s disease (PD) is a progressive neurodegenerative disorder caused by the selective loss of the dopaminergic neurons in the Substantia nigra pars compacta region of the brain.
Tito, Antonio Joel, Jr., Zhang, Sheng
core   +1 more source

Attenuated PINK1 autophosphorylation play neuroprotective and anti-seizure roles in neonatal hypoxia

Scientific Reports
This study investigated the roles and mechanisms of PINK1 activity in neonatal hypoxia-induced seizures with shRNA intervention targeting translocase outer mitochondrial membrane 7 (TOM7), the positive regulator of PINK1 autophosphorylation, or ...
Yi Yuan, Xiaoqian Wang, Yaru Cui, Hua Zhou, Wenna Li, Qian Teng, Hongjin Wang, Bohan Sun, Qiaoyun Wang, Hongliu Sun, Jianhua Tang   +10 more
doaj   +1 more source

PINK1 modulates Prdx2 to reduce lipotoxicity‐induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction

Clinical and Translational Medicine
Introduction Heart failure with preserved ejection fraction (HFpEF) is a complex condition characterized by metabolic dysfunction and myocardial lipotoxicity.
Hao Zhang, Tianyu Xu, Xiyuan Mei, Qiming Zhao, Qiling Yang, Xianghui Zeng, Zhuang Ma, Haobin Zhou, Qingchun Zeng, Dingli Xu, Hao Ren   +10 more
doaj   +1 more source

Evaluation of PINK1 protein expression as a predictive marker for the efficacy of adjuvant chemotherapy in colorectal cancer: a retrospective study

BMC Gastroenterology
Background PTEN-induced kinase 1 (PINK1) is involved in mitochondrial quality control via mitophagy, and recent studies have reported that its overexpression is associated with chemoresistance and poor prognosis in multiple malignant tumors. However, the
Takatsugu Fujii, Masataka Hirasaki, Yasuo Kamakura, Tomonori Kawasaki, Satoshi Yamasaki, Yasuhiro Ishiyama, Chikashi Hiranuma, Tetsuya Hamaguchi, Yasumitsu Hirano, Shinichi Sakuramoto   +9 more
doaj   +1 more source

Correction: Erythropoietin mitigates diabetic nephropathy by restoring PINK1/Parkin-mediated mitophagy. [PDF]

Front Pharmacol
Yi X, Yan W, Guo T, Liu N, Wang Z, Shang J, Wei X, Cui X, Sun Y, Ren S, Chen L.   +10 more
europepmc   +1 more source

Promoting mitochondrial dynamics by inhibiting the PINK1–PRKN pathway to relieve diabetic nephropathy

Disease Models & Mechanisms
Jun-yi Zhu, Joyce van de Leemput, Zhe Han   +2 more
doaj   +1 more source

Novel mechanism of neuronal hypoxia response: HIF-1α/STOML2 mediated PINK1-dependent mitophagy activation against neuronal injury. [PDF]

Cell Death Discov
Li Y, Xu Z, Tian Z, Guo M, Shao Q, Liu Y, Gu Y, Jin F, Ji X, Liu J.   +9 more
europepmc   +1 more source

Targeting the PINK1/Parkin-FNDC5 pathway: a novel mechanism of icariin in regulating muscle-bone metabolic coupling in osteosarcopenia. [PDF]

J Transl Med
Zhao M, Yuan F, Liu C, Guo T.
europepmc   +1 more source

Overloaded mitochondrial stress drives reproductive damage in GC-1 mouse spermatogonia cells exposed to nickel nanoparticle. [PDF]

Cell Biol Toxicol
Kong L, Liang G, Wāng Y.
europepmc   +1 more source

Mastering cardiomyocyte mitophagy: molecular governance, pathological derailment and therapeutics. [PDF]

PeerJ
Liu P, Wu H, Ren H, Wang J, Yang F.
europepmc   +1 more source