Results 171 to 180 of about 23,381 (243)

Alzheimer's Biomarkers and Visuospatial Cognition in Parkinson's Disease: Modification by α‐Synuclein and Mediation of Age Effects

Movement Disorders Clinical Practice, Volume 13, Issue 8, Page 1861-1875, August 2026.
Abstract Background Visuospatial deficits in Parkinson's disease (PD) often precede dementia and complicate daily functioning. Alzheimer's disease (AD) pathology and α‐synuclein aggregation frequently co‐occur in PD, but their combined impact on cognition is unclear.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Meher Lad, Mark R. Baker, Nicola Pavese   +8 more
wiley   +1 more source

ATG5 Plays a Role in <i>Toxoplasma gondii</i> Replication and Egress Within Host Cells. [PDF]

Transbound Emerg Dis
Wu F, Wu S, Ding Q, Shi Z, Liang Y, Chen H, Zhang X, Mi J, Chen M, Xu Q.   +9 more
europepmc   +1 more source

Unveiling the AcSirt2‐FOXO‐Mitophagy Axis: Insights Into Mitochondrial Quality Control and Delayed Aging in Apis cerana

Aging Cell, Volume 25, Issue 8, August 2026.
Age‐related downregulation of AcSirt2 impairs mitochondrial homeostasis in old bees. AcSirt2‐mediated deacetylation of FOXO enhances transcriptional activity, upregulating antioxidant enzymes (SOD, CAT) and promoting PINK1/Parkin‐mediated mitophagy. This pathway facilitates autophagosome formation and clearance of damaged mitochondria, reducing ROS ...
Qiang Ma, Zhengang Ma, Tingyue Huang, Qianmin Hai, Xiaoqun Dang, Jinshan Xu, Jialing Bao, Zachary Y. Huang, Zeyang Zhou   +8 more
wiley   +1 more source

Mitophagy in kidney and lung epithelial cells: molecular mechanisms, crosstalk, and therapeutic interventions. [PDF]

Front Physiol
Zhou X, Sun J, Miao L, Zhang Y.
europepmc   +1 more source

Mesenchymal Stromal Cell Rejuvenation Strategies to Enhance Clinical Translation in Cell Therapy

Aging Cell, Volume 25, Issue 8, August 2026.
MSC rejuvenation strategies and functional outcomes. Aging‐associated alterations in MSCs, including increased IL‐6/IL‐8 secretion, ROS accumulation, epigenetic drift, and mitochondrial dysfunction, impair stemness. Rejuvenation approaches, epigenetic modulation (VPA, AZAc, OSKM, TERT), metabolic interventions (resveratrol, calcitriol, NMD, asprosin ...
Astrid Sodomaco, Irene Bernardi, Aretha Rambaldi, Pierluigi Lombardi, Maura Rossi, Francesca Paris, Lucia Manzoli, Stefano Ratti, Francesco Alviano   +8 more
wiley   +1 more source

A single-nucleus RNA-seq dataset of the colon in Pink1-deficient and wild-type mice. [PDF]

Sci Data
Junaid M, Park SJ, Bae Y, Lee EJ, Bin Lim S.   +4 more
europepmc   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

FTMT-mediated suppression of mitophagy links iron accumulation to osteoporosis. [PDF]

Redox Biol
Zhang R, Wang Y, Li L, Li J, Feng G, Hu Y, Liu G, Wang X, Zhang J, Wei P, Lai H, Zhu K, Wang X, Gao X, Wei W, Fang Y, Wang J, Yuan N, Xu Y.   +18 more
europepmc   +1 more source

Quantitative In Vivo Imaging of ATP Dynamics in Drosophila Using the Ratiometric Biosensor QUEEN

Development, Growth &Differentiation, Volume 68, Issue 6, August 2026.
ABSTRACT Genetically encoded ATP biosensors enable monitoring of cellular energy status, but their application in multicellular organisms remains limited. QUEEN is a ratiometric ATP biosensor consisting of a bacterial ATP‐binding protein fused to a circularly permuted fluorescent protein and has been primarily validated in cultured cells.
Yuhan Luo, Sayaka Sekine, Naoto Kasahara, Hiroyuki Uechi, Takafumi Toyohara, Takaaki Abe, Erina Kuranaga   +6 more
wiley   +1 more source

Senescent BMSC-Derived Thbs1 Drives Inflammaging and Impairs Bone Regeneration by Suppressing PINK1/Parkin-Mediated Mitophagy in Macrophages. [PDF]

Aging Cell
Xing Y, Su J, Lin Y, Huang N, Zhang S, Zhou Y, Lu J, Chen W, He K, Yuan W, Li Y, Zheng G, Hu P, Wu D, Ou Y, Chen J.   +15 more
europepmc   +1 more source