Results 181 to 190 of about 23,381 (243)

PRKCD Orchestrates Sevoflurane‐Induced Cognitive Dysfunction in Aged Rats by Regulating PINK1/PRKN Mitophagy Pathway

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Post‐operative cognitive dysfunction (POCD) is a cognitive disorder characterized by a decline in cognitive function following surgical procedures, with mitophagy identified as a significant underlying mechanism. Protein kinase C delta (PRKCD), localized within the mitochondria, is implicated in the regulation of PINK1/PRKN mitophagy pathway ...
Yang Yu, Wei Zhang, Yingying Zhao, Yue Zhang, Pingle Li, Zepeng He   +5 more
wiley   +1 more source

Salidroside Protects Against Simazine-Induced Neurotoxicity by Activating <i>PINK1/Parkin</i> Mitophagy. [PDF]

Int J Mol Sci
Li X, Xiang Y, Li J, Song H, Zhao C, Li B.   +5 more
europepmc   +1 more source

Therapeutic intervention with sinomenine and irisin to preserve cardiac function after ischaemia–reperfusion injury

Experimental Physiology, Volume 111, Issue 8, Page 3557-3569, 1 August 2026.
Abstract Despite advancements in reperfusion therapy, myocardial ischaemia–reperfusion (IR) injury remains a major clinical challenge. This study investigated whether a novel dual‐target pre‐conditioning strategy using sinomenine and irisin could enhance myocardial resistance against IR injury. Ninety male Sprague–Dawley rats were utilized.
Lianjun Wu, Sining Bi, Amany Belal, Zhuzhu Liu   +3 more
wiley   +1 more source

Oxymatrine alleviates cognitive dysfunction in mice caused by chronic cerebral hypoperfusion by promoting SIRT1/ PINK1-mediated mitophagy. [PDF]

Front Pharmacol
Tong B, Li X, Hu W, Ding B, Chen J, Gong J, Gu L, Shi L.   +7 more
europepmc   +1 more source

Impairments in mitochondrial dynamics and morphology in skeletal muscle of breast cancer patients after a single paclitaxel administration

Experimental Physiology, Volume 111, Issue 8, Page 3502-3513, 1 August 2026.
Abstract Standard chemotherapy regimens for patients with breast cancer are based on epirubicin–cyclophosphamide (EC) and paclitaxel (TAX) administrations. While it has been shown that first EC administration impairs mitochondrial homeostasis, the isolated effects of TAX have not been studied without previous chemotherapy exposure.
Joris Mallard, Elyse Hucteau, Laura Somme, Hervé Bischoff, Valérie Demais, Pauline Silvestrin, Anne‐Laure Charles, Roland Schott, Xavier Pivot, Thomas J. Hureau, Allan F. Pagano   +10 more
wiley   +1 more source

CHK1 activates mitophagy to attenuate cardiac aging via inhibiting AHSA1-ubiquitination. [PDF]

Redox Biol
Jing P, Zhou LH, Chen SX, Chen JY, Gu LF, Yang TT, Wang SB, Du C, Chen YX, Wang QM, Wang LS, Wang H.   +11 more
europepmc   +1 more source

A high‐fat, high‐sucrose diet exacerbates muscle and metabolic pathology and undermines glucocorticoid efficacy in dystrophin‐deficient mice

The Journal of Physiology, Volume 604, Issue 15, Page 6440-6464, 1 August 2026.
Abstract figure legend A high‐fat, high‐sucrose diet (HFHSD) exacerbated muscle and metabolic dysregulation in mdx mice while also altering the physiological response to prednisolone (Pred) In diaphragms of control diet (CD)‐fed mdx mice, prednisolone treatment improved muscle function and reduced fibrosis, inflammatory signalling, and mitochondrial ...
Morgan E. Vorwald, Swathy Krishna, Ji Heun Lee, Melissa Roths, Rudy J. Valentine, Joshua T. Selsby   +5 more
wiley   +1 more source

Steroids and flavonoids in TRQ ameliorates chronic obstructive pulmonary disease involving Pink1/Parkin-mediated mitophagy. [PDF]

Sci Rep
Wang H, Xu Z, Du H, Liu J, Zhang T, Wei X, Liu Y, Chen T, Gao Y, Song L, Wang S, Ye Z, Zhang G, Hou H, Liu L.   +14 more
europepmc   +1 more source

Melatonin as a protector against endocrine disruption across tissues: A systematic review

Physiological Reports, Volume 14, Issue 15, August 2026.
Graphical Abstract showing the biological mechanisms by which melatonin protects tissues against endocrine disruption. Abstract Endocrine‐disrupting chemicals (EDCs) are widespread environmental pollutants that interfere with hormonal homeostasis and contribute to multisystem toxicity.
Clenie Isingizwe, Gaudence Ndinganire, Abdullateef Isiaka Alagbonsi   +2 more
wiley   +1 more source

Mitophagy-activating nanozyme hydrogel for enhanced diabetic wound healing. [PDF]

Mater Today Bio
Zhang J, Tang Z, Zhang X, Zhang H, He W.
europepmc   +1 more source