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[Molecular genetics of PINK1].
Brain and nerve = Shinkei kenkyu no shinpo, 2007PTEN-induced putative kinase 1 (PINK1) is a causative gene for autosomal recessive early onset parkinsonism. Mutations in PINK1 were identified originally in PARK6-linked parkinsonism families from Italy and Spain. PINK1 contains 8 exons spanning 1.8 kb, and encodes a protein of 581 amino acids with a mitochondrial targeting motif and a serine ...
Manabu, Funayama, Nobutaka, Hattori
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PINK1: Multiple mechanisms of neuroprotection
2021Britney N, Lizama +2 more
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Autophagy
Mutations in the PINK1 kinase cause Parkinson disease (PD) through physiological processes that are not yet fully elucidated. PINK1 kinase accumulates selectively on damaged mitochondria, where it recruits the E3 ubiquitin ligase PRKN/Parkin to mediate mitophagy.
Mohamed A. Eldeeb +5 more
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Mutations in the PINK1 kinase cause Parkinson disease (PD) through physiological processes that are not yet fully elucidated. PINK1 kinase accumulates selectively on damaged mitochondria, where it recruits the E3 ubiquitin ligase PRKN/Parkin to mediate mitophagy.
Mohamed A. Eldeeb +5 more
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Mitochondrial PINK1—A Novel Cardioprotective Kinase?
Cardiovascular Drugs and Therapy, 2008Hilary K, Siddall +4 more
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